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The map label for this gene is hemD [H]

Identifier: 126176188

GI number: 126176188

Start: 4689386

End: 4690084

Strand: Direct

Name: hemD [H]

Synonym: Sbal_4001

Alternate gene names: 126176188

Gene position: 4689386-4690084 (Clockwise)

Preceding gene: 126176187

Following gene: 126176189

Centisome position: 91.46

GC content: 51.36

Gene sequence:

>699_bases
ATGGTCGATGCCTTGAATGAACGAGGTATTGCCCACTGGGTCACACCTCTGCTGTGTGTCGAAGCAACGCCCGCTATCGC
AACGAATACCCCGCATCCTTTGGCACACGCCGATATGATTATCTGCATCAGCGCCAATGCTGTGACTTTTGCGGATAACA
CCTTAACTACTACAAATCCACCCCATAAAGCTTGGCCTCCAGCTCAGTACTTCGCGGTAGGGCATGCGACTTGGGACGCA
TTAAACCAACTCGGTATTTCTGCCCTAGAAGCCCCTGATGACTGTCAGCAGACCGAAGGGCTACTCACGCTCGTGCCGCT
GCAAGAGATTAAAGGTCAGCAGATTACTATTATACGTGGCGTCGGTGGCCGCGAAGCCTTAGCCGAACAACTGGCTGCGC
GCGGTGCACATTTGCGCTATTGGGAAGTGTATCAACGAGCTTGTCCGCCACTCGATGGTCAACAGTTAGCTCTGCAATGG
CAAGCCTTCGGGATAGACACGATTGTGGTGACCAGCGGTGAAGTACTGGATAACCTGATTAATTTAGTGCCAAAAGAGTT
ATTTGCATGGCTGCGCTCATGTCATATCATAGTCCCAAGTAACCGAGTAGAAGCTCAAGCTCACGCCTTTGGTATAACCC
AAGTCACCAATGCCAATGCCGCCAACAGCAAAGCCGTGCTAAACGCCCTTAAACTCTAA

Upstream 100 bases:

>100_bases
TTACTCAGCAAAGGTGCCAAAACCATTCTCGACGCCGTTTACGCTAAAGCCTAAGTCAATGAAAGTCTTACTGACGCGCC
CCGAGGGGCGCAATCAGTCC

Downstream 100 bases:

>100_bases
GCGCTATTTAGCCCGATTTTACTCGAATTTCGGCAGTAGCATGTTTTCAAGGACTGTTAAATGGATAACAACAAGCACGA
CGCAAAGAGCCCAGAATCAG

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNTLTTTNPPHKAWPPAQYFAVGHATWDA
LNQLGISALEAPDDCQQTEGLLTLVPLQEIKGQQITIIRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQW
QAFGIDTIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL

Sequences:

>Translated_232_residues
MVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNTLTTTNPPHKAWPPAQYFAVGHATWDA
LNQLGISALEAPDDCQQTEGLLTLVPLQEIKGQQITIIRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQW
QAFGIDTIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL
>Mature_232_residues
MVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNTLTTTNPPHKAWPPAQYFAVGHATWDA
LNQLGISALEAPDDCQQTEGLLTLVPLQEIKGQQITIIRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQW
QAFGIDTIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=236, Percent_Identity=34.3220338983051, Blast_Score=123, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 25086; Mature: 25086

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNTLTTTNP
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCEECCCC
PHKAWPPAQYFAVGHATWDALNQLGISALEAPDDCQQTEGLLTLVPLQEIKGQQITIIRG
CCCCCCCHHHEEEHHHHHHHHHHHCCHHCCCCCHHHHHCCCEEEEEHHHHCCCEEEEEEC
VGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAFGIDTIVVTSGEVLDNLI
CCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEEECCEEEEEECHHHHHHHH
NLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL
HHHHHHHHHHHHHCEEEECCCCCCHHHHHCCEEEECCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNTLTTTNP
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCEECCCC
PHKAWPPAQYFAVGHATWDALNQLGISALEAPDDCQQTEGLLTLVPLQEIKGQQITIIRG
CCCCCCCHHHEEEHHHHHHHHHHHCCHHCCCCCHHHHHCCCEEEEEHHHHCCCEEEEEEC
VGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAFGIDTIVVTSGEVLDNLI
CCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEEECCEEEEEECHHHHHHHH
NLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL
HHHHHHHHHHHHHCEEEECCCCCCHHHHHCCEEEECCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]