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The map label for this gene is hemC [H]

Identifier: 126176187

GI number: 126176187

Start: 4688407

End: 4689339

Strand: Direct

Name: hemC [H]

Synonym: Sbal_4000

Alternate gene names: 126176187

Gene position: 4688407-4689339 (Clockwise)

Preceding gene: 126176186

Following gene: 126176188

Centisome position: 91.44

GC content: 50.48

Gene sequence:

>933_bases
ATGTCTGAGAACCGCATACGTATCGCAACCCGCAAGAGTCCGCTGGCCATGTGGCAAGCTGAATTTGTTAAAGCCGAATT
AGAACGCATTCACCCAGGTATTGTGGTGGAATTGCTGCCAATGAGCACTAAAGGCGACGTTATCTTAGATACGCCGCTAG
CCAAAGTGGGCGGTAAAGGTTTGTTCGTCAAAGAGCTTGAAGTCGCTATGTTAGACGATCTTGCCGATATCGCCGTGCAC
TCAATGAAAGACGTGCCCGTCGACTTCCCAGAAGGCTTAGGCCTTGAAGTGATTTGCGAGCGCGAAGATCCCCGCGATGC
CTTTGTATCGAATTTATATAAATCGATCAGCGAATTACCATTAGGCGCAACTGTGGGCACCTCGAGCCTACGTCGTCAAT
GTCAGATACGTGCATCACGTCCCGACCTCATCATCAAAGATTTACGCGGTAACGTTGGAACTCGTTTAGCTAAGCTTGAT
AACGGCGAATACGATGCCATTATTCTTGCCGCTGCAGGCTTAATCCGTCTGAAATTGTCTGAGCGTATTGCCAGCTTTAT
TTCTGCCGAAGAATCCTTACCCGCCAACGGCCAAGGCGCTGTGGGTATCGAATGTCGCATCAACGACGAACGTGTTAAAG
CGCTACTGGCGCCATTAGAGCATTTAGAAACTCGCTACCGTGTTCTTGCCGAGCGCGCGATGAACACTCGCCTTGAAGGT
GGATGCCAAGTGCCGATTGGCGCATTTGCTGAAATCGATGGTGACGAGATGACGCTACGCGGCCTAGTCGGTAACCCAGA
TGGCAGTGAAATCATCGAAGGCGTGATCACAGGTCCAAAAACCGAAGCCACGCAATTAGGGGTTGCCCTTGCTGAAGAGT
TACTCAGCAAAGGTGCCAAAACCATTCTCGACGCCGTTTACGCTAAAGCCTAA

Upstream 100 bases:

>100_bases
GAGAACATCGCCGACTTCAAAGAATCGATACGGCTTCCTTACATAAACGATTTGCCAATGTTAGCATTGGTGCAACTAAG
ATCTTTGATGGAAACTAGGC

Downstream 100 bases:

>100_bases
GTCAATGAAAGTCTTACTGACGCGCCCCGAGGGGCGCAATCAGTCCATGGTCGATGCCTTGAATGAACGAGGTATTGCCC
ACTGGGTCACACCTCTGCTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLDDLADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLD
NGEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTEATQLGVALAEELLSKGAKTILDAVYAKA

Sequences:

>Translated_310_residues
MSENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLDDLADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLD
NGEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTEATQLGVALAEELLSKGAKTILDAVYAKA
>Mature_309_residues
SENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLDDLADIAVHS
MKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLDN
GEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEGG
CQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTEATQLGVALAEELLSKGAKTILDAVYAKA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=41.2650602409639, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=41.2650602409639, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=69.3811074918567, Blast_Score=423, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.3177570093458, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI20130425, Length=261, Percent_Identity=42.5287356321839, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33461; Mature: 33330

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKG
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHCCCC
LFVKELEVAMLDDLADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELP
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
LGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLDNGEYDAIILAAAGLIRLKLS
CCCCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHHEEEECCCCCCCEEEEEHHHHHHHHHH
ERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTEATQLGVALAEELLSKGAK
CCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHH
TILDAVYAKA
HHHHHHHHCC
>Mature Secondary Structure 
SENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKG
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHCCCC
LFVKELEVAMLDDLADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELP
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
LGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLDNGEYDAIILAAAGLIRLKLS
CCCCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHHEEEECCCCCCCEEEEEHHHHHHHHHH
ERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTEATQLGVALAEELLSKGAK
CCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHH
TILDAVYAKA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA