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The map label for this gene is frdB [H]

Identifier: 126176124

GI number: 126176124

Start: 4627121

End: 4627852

Strand: Reverse

Name: frdB [H]

Synonym: Sbal_3934

Alternate gene names: 126176124

Gene position: 4627852-4627121 (Counterclockwise)

Preceding gene: 126176125

Following gene: 126176121

Centisome position: 90.26

GC content: 49.04

Gene sequence:

>732_bases
ATGAGCCAAGGTCGTCAGTTAACCTTTAATATCTTTCGTTATGATCCGCAGGAGCCAAACGATAAGCCGAAAATGGTGCG
ATATCAGCTCACTGAAACACCGGGTATGACGGTCTTTATCGCCCTCAATAAACTCAGGGAAGAACAAGATACCTCGATGC
AGTTCGACTTTGTTTGTCGTGCGGGCATTTGTGGCAGTTGCGCTATGGTGATTAACGGTTTCCCGACGTTAGCGTGTCGT
ACCTTAACCGCCAAATATCCTAAGGGCGAAATCACTCTAATGCCGCTGCCAGGCTTTGAGTTGATTGGCGACCTATCAGT
CAATACCGGTAAGTTTATGCGGGAATTGGCCGAACGCTTAAAGCTGTGGTTACACCCTAAGGCCAATGACATCAGTGTGC
ATCGCCTCGAAGATCCAATGGATCCAGACGAAGCTGCGCGCCTGTATGAGCTAGAGCGCTGCGTTGAGTGCGGCGTGTGT
GTTTCAGCTTGTGCGACCAAACAAATGCGTGAAACCTTTGTCGGCGCCGTAGGTATGATGAAAATTGCCCGTTTCGAGAT
GGATAGCCGTGATGCGCGCAGTGCCGAGGATTTTTACCATGTGATTGGTAATCAGGATGGGGTGTTTGGTTGTATGACTT
TACTCGGCTGCCAAGACAACTGTCCTAAGGATTTGCCACACATGCAGCAAATCGCCTATTTACGCCGCAAGATGGCCATG
ACTTTGATTTAA

Upstream 100 bases:

>100_bases
TTATGCCCTTTGAATTGCCCGAAAGCTTACAACCCAATAATGAACGTTTAAGTGATACCTTAAAAAGCCCGTCCGCCAAT
GCGTTAGGAGAAAAATCATA

Downstream 100 bases:

>100_bases
TTCATTATGAAAAATGAAAGCGCCAACTCGTTTGGCGCTTTTTATTGATTAACAGGCGTAGCTTTTATGGATGTCAGCTC
GACTGATTAAGTCTGCCGTT

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSMQFDFVCRAGICGSCAMVINGFPTLACR
TLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKANDISVHRLEDPMDPDEAARLYELERCVECGVC
VSACATKQMRETFVGAVGMMKIARFEMDSRDARSAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
TLI

Sequences:

>Translated_243_residues
MSQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSMQFDFVCRAGICGSCAMVINGFPTLACR
TLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKANDISVHRLEDPMDPDEAARLYELERCVECGVC
VSACATKQMRETFVGAVGMMKIARFEMDSRDARSAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
TLI
>Mature_242_residues
SQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSMQFDFVCRAGICGSCAMVINGFPTLACRT
LTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKANDISVHRLEDPMDPDEAARLYELERCVECGVCV
SACATKQMRETFVGAVGMMKIARFEMDSRDARSAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAMT
LI

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=236, Percent_Identity=31.3559322033898, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786943, Length=235, Percent_Identity=31.063829787234, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790596, Length=225, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=28.6324786324786, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322987, Length=240, Percent_Identity=30.8333333333333, Blast_Score=116, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17137106, Length=237, Percent_Identity=30.379746835443, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=28.6324786324786, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27558; Mature: 27427

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
11.1 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
10.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSMQFDFVCR
CCCCCEEEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHCCCEEEEHEEC
AGICGSCAMVINGFPTLACRTLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERL
CCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHH
KLWLHPKANDISVHRLEDPMDPDEAARLYELERCVECGVCVSACATKQMRETFVGAVGMM
HEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIARFEMDSRDARSAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
HHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
TLI
HCC
>Mature Secondary Structure 
SQGRQLTFNIFRYDPQEPNDKPKMVRYQLTETPGMTVFIALNKLREEQDTSMQFDFVCR
CCCCEEEEEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHCCCEEEEHEEC
AGICGSCAMVINGFPTLACRTLTAKYPKGEITLMPLPGFELIGDLSVNTGKFMRELAERL
CCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHEECCCCCHHHHHHHHHHHH
KLWLHPKANDISVHRLEDPMDPDEAARLYELERCVECGVCVSACATKQMRETFVGAVGMM
HEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIARFEMDSRDARSAEDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAM
HHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
TLI
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]