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The map label for this gene is frdA [H]

Identifier: 126176125

GI number: 126176125

Start: 4627852

End: 4629858

Strand: Reverse

Name: frdA [H]

Synonym: Sbal_3935

Alternate gene names: 126176125

Gene position: 4629858-4627852 (Counterclockwise)

Preceding gene: 126176126

Following gene: 126176124

Centisome position: 90.3

GC content: 51.77

Gene sequence:

>2007_bases
GTGAAACTGATTTATACCGATTCATTAGTGGTAGGCGCCGGACTCGCTGGCTTAAGGGTCGCCATCGCCTCGAAAGAGCG
TGGACTCGATACCTTAGTCCTGTCACTCATTCCTGCGAAACGCTCCCACTCAGCTGCCGCCCAAGGCGGTATGCAGGCGA
GCTTAGGCAATGCCGTAAAAGGCATGGGCGATGATGAAGATGTACATTTTCAAGATACGGTAAAAGGTTCCGACTGGGGC
TGCGATCAAGATGTGGCGCGGATGTTTGCTCACTGTGCACCCAAGGCGGTGCGTGAATTGGCGACGTGGGGCGTGCCTTG
GTCAAGGGTGAGTGCAGGCCCAAGAGACGTGATTGTGAACGCGCAAAAAGTGACACTGCATGAGGCGCAGGAAGCCCATG
GACTGATTAACGCCCGTGACTTTGGCGGCACAAAAAAATGGCGCACTTGCTACACGGCCGATGGTACGGGTCATTCGCTG
TTATACGCTATGGATAACAAAGCGATTTCTATGGATATTCCCGTCCATGAACGTATCGAAGCGCTGGCACTGATTCACAA
TGGTAAACGTTGCCATGGGGTGATCGCCCGCTGTTTGATAACCGGTGAACTCAGGGCCTATGTGGCTAAGTCCACCACCA
TTGCCACTGGCGGATATGGCCGCATTTATGAAGTGTCGACCAATGCGATCATCTGCGAAGGCATTGGTCAAGCACTCGCG
TTGGAAACGGGCGTGGCAAGGCTTGGCAATATGGAAGCGGTACAATTCCATCCTACCGCCATTGTTCCCGTGGGCATTTT
AACTACAGAAGGTTGCCGTGGTGATGGCGGCTTATTGCGTGATAAAGACGGTTATCGCTTTATGCCAGACTATGAGCCCG
ATAAAAAAGAGTTGGCATCGCGAGATGTGGTATCGCGCCGCATGACAGAACATATAAGGAAAGGGAAGGGCGTTGATAGC
CCCTATGGACCGCATTTGTGGCTGGATATTACCCTTCTGGGTCGCAAGCATATTGAAACTAACCTAAGGGAAGTGCAGGA
AATTTGTGAGAACTTCCTCGGTATCGACCCCGCTAAGGATTGGATCCCAGTACGGCCAACGCAGCATTATTCCATGGGCG
GCATTCGAACCAATGCCACGGGTGAAAGCCCGCAGCTTAAAGGCTTGTTTAGCGTCGGCGAAGCGGCGTGTTGGGACATG
CATGGTTTTAACCGTTTAGGCGGTAATTCGCTTGCCGAAACCGTGGTTGGTGGCATGATTATTGGTAAATATGTCGCCGA
TTTTTGTGAGAACAATAGCCTAGAGATAGACACTCAGCTTGCTGAACGGTTTATGCAGCAGGTGCAGAGTGAAATAGATC
TGCTGATCGAGGGCGATGGCCACGAGAGCGCCTTTGCCCTCAAACGCGAAATGCAGCGCATCATGATGGATTATGTGGGG
ATTTTCCGTAATGGCCCTGAGCTTGATAAAGCCGTCGCTGAACTTAAAGTGCTGCTCGAACGTTCGCGTAAGCTTGGGCT
TAAGTGTAAAAAGCGTCACGCCAATCCTGAGTTAGTTGAAGCCCTGCGGGTCAAGCGCATGCTCAAAGTAGCGCTGACTG
TGGCCTGCGGCGCAGCGGCACGAACCGAAAGTCGTGGTGCCCATGCTCGAGAAGATTATCCACAGCGCAATGATCGCGAT
TGGCTAAATCGTACCTTAGCCAGTTGGCCGGATCCCGATGCGCTCGAACCTGTGCTTAATTACGAAGCGCTCGATGTGAT
GAAGATGGAACTCCCGCCGGGTTATCGTGGCTATGGTATTAACAACGCCATAGTGCATCCCGATACCGAAAAACGTGAAC
AGCAGATTGCCAATATTCTAGCCGAGCTAGGTGAGGATGCAGACCGTTATCAACGCCAGCGGGCGCTTATGCCCTTTGAA
TTGCCCGAAAGCTTACAACCCAATAATGAACGTTTAAGTGATACCTTAAAAAGCCCGTCCGCCAATGCGTTAGGAGAAAA
ATCATAA

Upstream 100 bases:

>100_bases
AAATTAATGAATAAGTAGATCAATGAATAAGCTTATTAATGAATAGAATGTCGAACATAGCAAACTGCACAAGAATAATA
GACCCGATTAAGGAGCAGGC

Downstream 100 bases:

>100_bases
TGAGCCAAGGTCGTCAGTTAACCTTTAATATCTTTCGTTATGATCCGCAGGAGCCAAACGATAAGCCGAAAATGGTGCGA
TATCAGCTCACTGAAACACC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVNAQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDIPVHERIEALALIHNGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVARLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELASRDVVSRRMTEHIRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDPDALEPVLNYEALDVMKMELPPGYRGYGINNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFE
LPESLQPNNERLSDTLKSPSANALGEKS

Sequences:

>Translated_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVNAQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDIPVHERIEALALIHNGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVARLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELASRDVVSRRMTEHIRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDPDALEPVLNYEALDVMKMELPPGYRGYGINNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFE
LPESLQPNNERLSDTLKSPSANALGEKS
>Mature_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVNAQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDIPVHERIEALALIHNGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVARLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELASRDVVSRRMTEHIRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDPDALEPVLNYEALDVMKMELPPGYRGYGINNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFE
LPESLQPNNERLSDTLKSPSANALGEKS

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=543, Percent_Identity=38.4898710865562, Blast_Score=321, Evalue=1e-87,
Organism=Escherichia coli, GI1786942, Length=611, Percent_Identity=36.8248772504092, Blast_Score=332, Evalue=5e-92,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=36.4565587734242, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=28.8256227758007, Blast_Score=172, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=38.3636363636364, Blast_Score=324, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI17550100, Length=545, Percent_Identity=38.8990825688073, Blast_Score=315, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6322701, Length=600, Percent_Identity=37.6666666666667, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=37.4367622259696, Blast_Score=326, Evalue=1e-89,
Organism=Drosophila melanogaster, GI17137288, Length=602, Percent_Identity=37.0431893687708, Blast_Score=330, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24655642, Length=602, Percent_Identity=37.0431893687708, Blast_Score=330, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24655647, Length=602, Percent_Identity=37.0431893687708, Blast_Score=330, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24663005, Length=571, Percent_Identity=34.5008756567426, Blast_Score=283, Evalue=4e-76,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73553; Mature: 73553

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCHHEEEE
AQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISMDIPVHERIE
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALALIHNGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCHHHH
LETGVARLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCCHHHHHH
RDVVSRRMTEHIRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHH
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDPDALEPVLNYEALDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHEEEEECCCCCCCCCC
NNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFELPESLQPNNERLSDTLKSPS
CCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCC
ANALGEKS
CCCCCCCC
>Mature Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCHHEEEE
AQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISMDIPVHERIE
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEECCHHHHHH
ALALIHNGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCHHHH
LETGVARLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCCHHHHHH
RDVVSRRMTEHIRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHH
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDPDALEPVLNYEALDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHEEEEECCCCCCCCCC
NNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFELPESLQPNNERLSDTLKSPS
CCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCC
ANALGEKS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]