Click here to switch to the map view.

The map label for this gene is deoA [H]

Identifier: 126175426

GI number: 126175426

Start: 3781262

End: 3782593

Strand: Reverse

Name: deoA [H]

Synonym: Sbal_3226

Alternate gene names: 126175426

Gene position: 3782593-3781262 (Counterclockwise)

Preceding gene: 126175427

Following gene: 126175425

Centisome position: 73.77

GC content: 48.12

Gene sequence:

>1332_bases
ATGTTTCTAGCTCAAGAGATTATTCGTAAAAAACGTAATGGTTTAGCGCTCTGTTCCGAAGAAATACAGTTCTTTGTACA
AGGTATCACCACCAACTCTGTATCTGAAGGTCAGATCGCCGCATTAGGTATGGCGGTGTATTTTAATGACATGAATATGG
ATGAAAGAATCGCTTTAACGACAGCGATGCGAGATTCAGGCACTGTGCTTAATTGGCAATCATTGGAACTCAACGGTCCT
GTCATCGACAAACACAGCACTGGTGGTGTCGGCGATGTGATTAGTCTCATGCTTGGCCCTATGGCTGCGGCTTGTGGCGG
TTATGTGCCTATGATTTCTGGGCGCGGCCTAGGTCATACTGGCGGTACACTCGATAAGTTTGATGCCATTCCGGGTTACC
AAACTGAGCCTTCAAGTGAATTGTTCCGCAAAGTGGTTAAAGAAGTCGGGGTGGCGATTATTGGCCAAACGGGCGATCTC
GTCCCTGCCGATAAACGCTTCTATTCTATTCGCGATAATACCGCTACCGTTGAATCCATTTCCCTCATCACAGCGTCGAT
TCTGTCTAAGAAATTAGCCTGTAATTTAGATGCGTTGGCGATGGACGTAAAAGTTGGTAGCGGCGCTTTCATGCCAACCT
ATGAGGCATCGGAAGAATTAGCTCGCAGTATCGCCGCCGTTGCAAATGGCGCGGGTACTAAAACGACGGCTTTACTTACC
GATATGAATCAAGTGCTTGCATCTTGTGCCGGTAACGCGGTTGAAGTGAAAGAAGCCATAGACTTTTTAACGGGTGCTTA
CCGTAACCCGCGTTTATATGAAGTCACTATGGGTCTTTGTGCTGAGATGCTGCTGCTTGGCGGTCTTGCAAGCAATGAAG
CCGATGCTCGCGCTAAACTGAATCGTGTACTCGACAATGGTCGCGCCGCAGAGCTCTTTGGCAAGATGGTGTCGGGTCTT
GGTGGTCCAGCCGATTTTGTTGAAAACTACAGTAAATACCTGCCGCAGTCACAAATTATTCGTCCGGTTTTTGCCGATAT
GCAAGGTTATGCCTACAGCATGGATACCCGTGAGTTAGGTTTAGCGGTTGTGACCTTAGGTGGCGGCCGTCGTAAGCCCG
GCGATGCACTAGACTATAGTGTTGGCTTAACCCAAGTGTGTGCCCTAGGCGATAAAGTGGATTCATCGACGCCAATTGCG
GTTATCCATGCACAGTCTGAAGCCGCGTTCGCAGAAGCTGAACTTGCGGTGAAAAAAGCGATTCACATTGGTGAAACCGC
TCCAGAAAAAACACCTGAGATCTATGCCTATATTCGTGCATCGGATCTTTAA

Upstream 100 bases:

>100_bases
TCGATAGTATGAACTTGTAATATTGCTACAGTTTTGATGTTTCATTGCAAAGATAAGCACTAGCGACAGGGTTGTTAGTG
TCTATCTTGGAGGCAGTATC

Downstream 100 bases:

>100_bases
GGAAAAATTATGAAACGTACCATTATTATGATGTTGGACTCCTTTGGAGTCGGTGCTTCTGCTGATGCAGCAAGTTTTGG
TGATGTCGGTTCCGATACTT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLAQEIIRKKRNGLALCSEEIQFFVQGITTNSVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLELNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNEADARAKLNRVLDNGRAAELFGKMVSGL
GGPADFVENYSKYLPQSQIIRPVFADMQGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKVDSSTPIA
VIHAQSEAAFAEAELAVKKAIHIGETAPEKTPEIYAYIRASDL

Sequences:

>Translated_443_residues
MFLAQEIIRKKRNGLALCSEEIQFFVQGITTNSVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLELNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNEADARAKLNRVLDNGRAAELFGKMVSGL
GGPADFVENYSKYLPQSQIIRPVFADMQGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKVDSSTPIA
VIHAQSEAAFAEAELAVKKAIHIGETAPEKTPEIYAYIRASDL
>Mature_443_residues
MFLAQEIIRKKRNGLALCSEEIQFFVQGITTNSVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLELNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNEADARAKLNRVLDNGRAAELFGKMVSGL
GGPADFVENYSKYLPQSQIIRPVFADMQGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKVDSSTPIA
VIHAQSEAAFAEAELAVKKAIHIGETAPEKTPEIYAYIRASDL

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=445, Percent_Identity=37.752808988764, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4503445, Length=445, Percent_Identity=37.752808988764, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI166158922, Length=445, Percent_Identity=37.752808988764, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=67.351598173516, Blast_Score=612, Evalue=1e-176,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 46950; Mature: 46950

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRNGLALCSEEIQFFVQGITTNSVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLELNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNEADARAKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAELFGKMVSGLGGPADFVENYSKYLPQSQIIRPVFADMQGYAYSMDTRELG
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHCC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKVDSSTPIAVIHAQSEAAFAEAELAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IHIGETAPEKTPEIYAYIRASDL
HHCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MFLAQEIIRKKRNGLALCSEEIQFFVQGITTNSVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLELNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKEVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACNLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
HHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYEVTMGLCAEMLLLGGLASNEADARAKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAELFGKMVSGLGGPADFVENYSKYLPQSQIIRPVFADMQGYAYSMDTRELG
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHCC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKVDSSTPIAVIHAQSEAAFAEAELAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IHIGETAPEKTPEIYAYIRASDL
HHCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA