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The map label for this gene is nadR [H]

Identifier: 125625006

GI number: 125625006

Start: 2203231

End: 2204370

Strand: Reverse

Name: nadR [H]

Synonym: llmg_2241

Alternate gene names: 125625006

Gene position: 2204370-2203231 (Counterclockwise)

Preceding gene: 125625007

Following gene: 125625005

Centisome position: 87.15

GC content: 37.37

Gene sequence:

>1140_bases
ATGCTCACAAATAATATTTCAAAATCAAAATTAAGTGGAAAAAATATTGGTATTTATTTTGGAACTTTTGCTCCTCTACA
TACGGGGCATCAGCAACAAATCTATAAATGTGCAAGTTTGAATGACGGGGTCTTGCTTGTCGTTTCCGGTTATGATAATG
ACCGTGGGGCCCAAATTGGTTTGCCCCTTGAAAAACGTTTTCGTTACTTGCGTGAAGCTTTTAATGATGAAGAAAATATT
AAAGTCTCGATGCTTAATGAAAATGATTTACCAGAAATGCCTAATGGTTGGGATGAATGGGCGAACCGCTTATTTGAATT
GATTCATCATAATACATTGGAAAACGATTTATCAGTCACTTTTTATGTGGGTGAATTAGAATACGCCGCAGAATTGAAGA
AACGATTTCCAGCTGACGGGAATCAATATGCTGTTGAAATTGCTGACAGACATGATATTTCACTGTCAGCCACGCAAATC
AGAGAAAATCCACAAGAACATTGGACTCACATTAATCGTGTCTTTAGACGACATTTTTCCAAAGTTGTGACTGTCATGGG
TTCTGCTTCAACGGGAAAAACAACTCTTGTTAGACGGTTGGCCCGTTCCATTAATGCCCCATTTTCAGAAGAATATGCAA
GAGAATACGAAGAAGCTTTCAATATTGACGATGATGAATTGAAAATGGATGATTATGCTCGAATGATTACTGGTCAATAC
GATGCCAATTCTCGCGAAGTCAATTCTCCTGCCAATCAAGGAATTGTCTTTTTAGATACTGACGCCATTGTGACCAGAGT
TTACGCTAAATTATACTTACCTAAAGAAGATTTTGAACAACTTGAACCTTTGTTTAGAAAAACTATTGCAGATGAACGAA
TGGATTTAATTTTAGTTATTCCACCAATTACAGAATATATTGATGACGGTTTTCGCCATATGGAGTGGGAAGAATCACGT
CATGAATTCCATGAAGAATTGATGCGGCAATTAGCTGAGTTTGGCCTGTTGGACAAAGTGGTAATTTTAGATGACGAAGG
AGACCATCGAGACCAAGAGGGTTACTTAACACGTTATCATCATGCGATTGATGCTGTTCACGAATATACCGGTGTAAAAA
TTGAACGATTGAGTTATTAA

Upstream 100 bases:

>100_bases
TGGCGTCGCTTTATGAAAATATTGGAAAAAAATCTCGATGCCTATGCAAATGGGAAGGATTTAACAAATATTGTTGATAT
GAAAACAGGATATAAACGAA

Downstream 100 bases:

>100_bases
TTTTACTGACAGCTTTATTTAGAAAATAAAAAGTTACTGACCAATCTATCAGTATCTTTTTTAGTTTTTATAAGAGATTT
TCAATATTAATTAATTCTTC

Product: putative nicotinamide-nucleotide adenylyltransferase

Products: NA

Alternate protein names: Transcriptional regulator NadR; Nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase; NMN-AT; NMNAT; Nicotinamide ribonucleotide adenylyltransferase; Nicotinamide-nucleotide adenylyltransferase; Ribosylnicotinamide kinase; RNK; Nicotinamide riboside kinase; NRK; NmR-K [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MLTNNISKSKLSGKNIGIYFGTFAPLHTGHQQQIYKCASLNDGVLLVVSGYDNDRGAQIGLPLEKRFRYLREAFNDEENI
KVSMLNENDLPEMPNGWDEWANRLFELIHHNTLENDLSVTFYVGELEYAAELKKRFPADGNQYAVEIADRHDISLSATQI
RENPQEHWTHINRVFRRHFSKVVTVMGSASTGKTTLVRRLARSINAPFSEEYAREYEEAFNIDDDELKMDDYARMITGQY
DANSREVNSPANQGIVFLDTDAIVTRVYAKLYLPKEDFEQLEPLFRKTIADERMDLILVIPPITEYIDDGFRHMEWEESR
HEFHEELMRQLAEFGLLDKVVILDDEGDHRDQEGYLTRYHHAIDAVHEYTGVKIERLSY

Sequences:

>Translated_379_residues
MLTNNISKSKLSGKNIGIYFGTFAPLHTGHQQQIYKCASLNDGVLLVVSGYDNDRGAQIGLPLEKRFRYLREAFNDEENI
KVSMLNENDLPEMPNGWDEWANRLFELIHHNTLENDLSVTFYVGELEYAAELKKRFPADGNQYAVEIADRHDISLSATQI
RENPQEHWTHINRVFRRHFSKVVTVMGSASTGKTTLVRRLARSINAPFSEEYAREYEEAFNIDDDELKMDDYARMITGQY
DANSREVNSPANQGIVFLDTDAIVTRVYAKLYLPKEDFEQLEPLFRKTIADERMDLILVIPPITEYIDDGFRHMEWEESR
HEFHEELMRQLAEFGLLDKVVILDDEGDHRDQEGYLTRYHHAIDAVHEYTGVKIERLSY
>Mature_379_residues
MLTNNISKSKLSGKNIGIYFGTFAPLHTGHQQQIYKCASLNDGVLLVVSGYDNDRGAQIGLPLEKRFRYLREAFNDEENI
KVSMLNENDLPEMPNGWDEWANRLFELIHHNTLENDLSVTFYVGELEYAAELKKRFPADGNQYAVEIADRHDISLSATQI
RENPQEHWTHINRVFRRHFSKVVTVMGSASTGKTTLVRRLARSINAPFSEEYAREYEEAFNIDDDELKMDDYARMITGQY
DANSREVNSPANQGIVFLDTDAIVTRVYAKLYLPKEDFEQLEPLFRKTIADERMDLILVIPPITEYIDDGFRHMEWEESR
HEFHEELMRQLAEFGLLDKVVILDDEGDHRDQEGYLTRYHHAIDAVHEYTGVKIERLSY

Specific function: This enzyme has three activities:DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase

COG id: COG3172

COG function: function code H; Predicted ATPase/kinase involved in NAD metabolism

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein. Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH cro/C1-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082440, Length=369, Percent_Identity=28.7262872628726, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016429
- InterPro:   IPR004821
- InterPro:   IPR001387
- InterPro:   IPR010982
- InterPro:   IPR006417
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01381 HTH_3 [H]

EC number: =2.7.7.1; =2.7.1.22 [H]

Molecular weight: Translated: 44062; Mature: 44062

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNNISKSKLSGKNIGIYFGTFAPLHTGHQQQIYKCASLNDGVLLVVSGYDNDRGAQIG
CCCCCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCEEC
LPLEKRFRYLREAFNDEENIKVSMLNENDLPEMPNGWDEWANRLFELIHHNTLENDLSVT
CCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
FYVGELEYAAELKKRFPADGNQYAVEIADRHDISLSATQIRENPQEHWTHINRVFRRHFS
EEECCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHH
KVVTVMGSASTGKTTLVRRLARSINAPFSEEYAREYEEAFNIDDDELKMDDYARMITGQY
HHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
DANSREVNSPANQGIVFLDTDAIVTRVYAKLYLPKEDFEQLEPLFRKTIADERMDLILVI
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
PPITEYIDDGFRHMEWEESRHEFHEELMRQLAEFGLLDKVVILDDEGDHRDQEGYLTRYH
CCHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
HAIDAVHEYTGVKIERLSY
HHHHHHHHHCCCEEEECCC
>Mature Secondary Structure
MLTNNISKSKLSGKNIGIYFGTFAPLHTGHQQQIYKCASLNDGVLLVVSGYDNDRGAQIG
CCCCCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCEEC
LPLEKRFRYLREAFNDEENIKVSMLNENDLPEMPNGWDEWANRLFELIHHNTLENDLSVT
CCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
FYVGELEYAAELKKRFPADGNQYAVEIADRHDISLSATQIRENPQEHWTHINRVFRRHFS
EEECCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHH
KVVTVMGSASTGKTTLVRRLARSINAPFSEEYAREYEEAFNIDDDELKMDDYARMITGQY
HHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
DANSREVNSPANQGIVFLDTDAIVTRVYAKLYLPKEDFEQLEPLFRKTIADERMDLILVI
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
PPITEYIDDGFRHMEWEESRHEFHEELMRQLAEFGLLDKVVILDDEGDHRDQEGYLTRYH
CCHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
HAIDAVHEYTGVKIERLSY
HHHHHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 1327967 [H]