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The map label for this gene is hisA

Identifier: 125624113

GI number: 125624113

Start: 1261572

End: 1262312

Strand: Reverse

Name: hisA

Synonym: llmg_1291

Alternate gene names: 125624113

Gene position: 1262312-1261572 (Counterclockwise)

Preceding gene: 125624114

Following gene: 125624112

Centisome position: 49.9

GC content: 34.82

Gene sequence:

>741_bases
ATGGAAATTATCCCAGCGATTGATTTACAAAATGGAGAAGCTGTGCGTCTCTACAAGGGGGATTATGATAAGAAAACGGT
CTACTCTAAAAATCCACTAGAAATTGCTCAAAAATTTGAACAAATGGAAGCAAAATATTTACATTTAGTCGACTTAGATG
GTGCTAAGCTAGGGCAAACCAGAAATTTAGAGATTGTGCGAAAAATAAAAGACCAAACTAATTTAAAAATCGAAATTGGT
GGTGGAATTAGAAATTTAGATACAGTTAGCCTTTATCTTGAACAGATTGGCGTAGAACGTGTGATTTTAGGGACGGCAGC
AGCAGAAAAACCTGATTTTCTTAAAGAACTGTTGGTTAAATATGGTTTGAGCAGAATTGTTGTTGGAGTGGATATTAGGG
AGGGTTTTGTCTCAACGAGTGGTTGGTTAGAAAAAACAACTCTTCCTTATCTATCATTTTTAAAAGATTTAGAGAAAATA
GGTGTTAAAACCGTCATTGTCACTGATATTTCCAAGGACGGTACGTTGACTGGACCGAATTTTGAACTTTATGATGAGAT
TTCAAAAGAAACTTCTTTAGATGTCATTGTTTCTGGTGGGGTAAAGGATAGTTCGGATATTCAACGAGCAGCAGATTCTG
ATTTCTATGGAATTATTGTTGGAAAAGCTTACTATGAAGGAAAAATTAATCTTGAAAAGGAGTTCAATCATGCTAACAAA
AAGAATTATCCCTTGTCTTGA

Upstream 100 bases:

>100_bases
CCATTGTGGGAAAAAATAACATTATTGGTTGTCAATTTCACCCAGAAAAAAGTGGAGAAATTGGCAGAAAAATACTAAGA
GCGTTTTTGGAGGAAATTTA

Downstream 100 bases:

>100_bases
TATTAAAAATGGTAAGGTCGTTAAGGGAATCAATTTTGTTGGTCTAAAAGAAATTGGTGACCCAGTGGAGCTAGCAAAAA
TATATGAAGAACAATGTGCA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMEAKYLHLVDLDGAKLGQTRNLEIVRKIKDQTNLKIEIG
GGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYGLSRIVVGVDIREGFVSTSGWLEKTTLPYLSFLKDLEKI
GVKTVIVTDISKDGTLTGPNFELYDEISKETSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEKEFNHANK
KNYPLS

Sequences:

>Translated_246_residues
MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMEAKYLHLVDLDGAKLGQTRNLEIVRKIKDQTNLKIEIG
GGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYGLSRIVVGVDIREGFVSTSGWLEKTTLPYLSFLKDLEKI
GVKTVIVTDISKDGTLTGPNFELYDEISKETSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEKEFNHANK
KNYPLS
>Mature_246_residues
MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMEAKYLHLVDLDGAKLGQTRNLEIVRKIKDQTNLKIEIG
GGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYGLSRIVVGVDIREGFVSTSGWLEKTTLPYLSFLKDLEKI
GVKTVIVTDISKDGTLTGPNFELYDEISKETSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEKEFNHANK
KNYPLS

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=237, Percent_Identity=35.4430379746835, Blast_Score=151, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_LACLM (A2RKR8)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001032596.1
- ProteinModelPortal:   A2RKR8
- SMR:   A2RKR8
- STRING:   A2RKR8
- GeneID:   4797807
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_1291
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 27471; Mature: 27471

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMEAKYLHLVDLDGAKLGQT
CCCCCCEECCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCC
RNLEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVK
CCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHH
YGLSRIVVGVDIREGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDISKDGTLTGPN
HCHHHEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCC
FELYDEISKETSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEKEFNHANK
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEEEEEEECCEEEEHHHHCCCCC
KNYPLS
CCCCCC
>Mature Secondary Structure
MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMEAKYLHLVDLDGAKLGQT
CCCCCCEECCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCC
RNLEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVK
CCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHH
YGLSRIVVGVDIREGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDISKDGTLTGPN
HCHHHEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCC
FELYDEISKETSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEKEFNHANK
HHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEEEEEEECCEEEEHHHHCCCCC
KNYPLS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA