Click here to switch to the map view.

The map label for this gene is purL [H]

Identifier: 125623815

GI number: 125623815

Start: 938802

End: 941021

Strand: Direct

Name: purL [H]

Synonym: llmg_0976

Alternate gene names: 125623815

Gene position: 938802-941021 (Clockwise)

Preceding gene: 125623814

Following gene: 125623816

Centisome position: 37.11

GC content: 40.59

Gene sequence:

>2220_bases
ATGACTTTGGAGATGTCACCAGAACAGATTCAAGAAAGCAAAATTTACCGTGAGTGGGGATTGACGGATGAAGAATATTT
GAAAATCAAGGATGAGATTCTTGGTGGACGCTTGCCAAACTTTACGGAAACTGGGATGTATGCCGTGATGTGGTCAGAAC
ATTGCTGCTACAAAAATTCAAAACCTGTCTTAAAAAAATTTCCGACGACTGGGCCGCAAGTCTTGATGGGACCTGGTGAA
GGGGCTGGGGTTGTGGATATTGGTGATGATTTGGCGGTTGTTTTCAAAGCTGAATCTCATAATCATCCATCTTACGTTGA
GCCTTATGAAGGTGCAGCAACAGGTTCTGGTGGTATTATTCGTGATATTTTTTCAATGGGGGCTCGTCCAATTGCAATTT
TGGATAGTTTGCGTTTTGGACCAATTGACAATGGTAAAACACGTCATATTGTTGACCAAGTGACAGCCGGAATTGCGGGA
TACGGAAACTGTATTGGCATTCCAACGGTTGGTGGCGAAGTGGCTTTTGATGAATCATACGCTGGTAATCCTTTAGTGAA
TGTCATGTGTGTGGGCTTAATTGAGCATAAACATATTCAAAAAGGACAAGCTAAAGGTGTGGGAAATTCTATTTTTTATG
TCGGAGCGAAAACAGGACGTGACGGCATTCATGGGGCATCTTTTGCTTCCAAAGAATTTGGTTCGGGCTCAGAAACACAA
CGTTCAGCCGTTCAAGTTGGCGACCCTTTTATGGAAAAACTATTGCTTGAAGCCTGTATTGAAGTTATCCAAAATCATGG
CGATATTTTAGTTGGAATTCAAGATATGGGTGCCGCTGGCTTGGTTTCATCGACTTCAGAAATGGCTTCAAAAGCTGGGT
CAGGTTTGCGTCTTAACTTGGATAATGTGCCACAGCGTGAAACAGAAATGATTCCTTATGAAATGATGTTGTCTGAGTCA
CAAGAGCGTATGGTGCTTTGTGTCAAAAAAGGACATGAACAAGAAATTATTGATTTATTTAAAAAATACGACCTTGATGC
TGTGAATATTGGGGAAGTGACTGATGATGGCTTTTATACACTTTATCATAAAGGGCAAATGGTTGCTCATGTTCCTGTTG
ATTCATTGGCAGAAGATGCACCGACTTATTACCGTGAGGCAAAAGTTCCTGAGCGCATTCAAAAATTTACTGACAGCGAG
AAATATCTTCCAGAAATTACTGACAGCGCGGTCAGTGAAATTTTCAAAAAACTTTTGGCTCAACCGACAATTGCCAGCAA
GAAATCAATTTATGAAACTTATGATTCGCGTGTGATGACCAACACCGTTGTTGCACCAGGCTCAGATGCCGCAGTTTTAC
GAGTGCGTGGCACAAACAAAGCACTTGCGATGACAACGGACTGTAATGCTCGTTATCTCTATCTTGACCCAGAAAAAGGT
GGAGCAATTGCGGTTGCCGAAGCGGCTCGTAATATTGTCGCCTCTGGTGGAAAACCACTTGCGATTACCGACTGTTTGAA
CTTTGGAAATCCGGAAAAACCAGAACAATTCTGGGAATTGACGACTGCCGCTGATGGAATTTCACGTTCTTGTTTGGCTC
TTGATACGCCTGTTATTTCAGGAAATGTCAGTCTTTACAATGAAACGAACGGTTCAGCTATTTTACCTACCCCAATGATT
GGAATGGTTGGTTTGATTGAGGATGTAAAAAATATTACGACTCAAGAATTTAAAAAAGCGGGTGATTTGATTGTATTAGT
CGGGCAAATTTTTGATGATTTTTCAGGTTCTGAACTTCAAAAAATGCTAACAGGCGAAATTTCTGGCAAGATTGATTTTG
ATTTAGAAACTGAAAAAGTCAATCAAGACTTTGTTTTAAAAGCAATTACTGACGGATTAATCAATTCAGCGCACGATTTG
TCAGAAGGTGGTCTAGCGATTGCCTTAGCTGAATCTGCTTTTGCAAATGGCTTAGGAATTGATGTAGAAGTTGATTTAAG
CAATGCTCAATTATTCTCAGAAACGCAAGGTCGCTTTGTACTCTCAATTTCACCAGAAAATCAAGCTGCTTTTGAAAAAT
TACTGACAGAAAGTTCTGCTAGTAGCGAAGTCATCGGAAAAGTTACTGACAACGGAATTTTGAAAATTAATGAACTTTCT
ATTTCTACTGACGAAGCTGTCAGCATTTATGAAGGAGCCCTTCCATGTCTGATGAAATGA

Upstream 100 bases:

>100_bases
AATTTGACAAAATTAAAAAACTGCACGAGCGCAGAACCATCAATTTTCCTAATTTTCACCACTTCAAAACAGTCGGGCTC
ACATCTTATAGGAGAAGAAC

Downstream 100 bases:

>100_bases
CAAGCGCAACATTTACTGAACAAGAGTGGTCGCATTTTGAGAAAAAAAGTTTGAATCAAACTGAAGCCGATGAGCTCCGC
GACTGGTCGCGGTTTGAAGC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MTLEMSPEQIQESKIYREWGLTDEEYLKIKDEILGGRLPNFTETGMYAVMWSEHCCYKNSKPVLKKFPTTGPQVLMGPGE
GAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGIIRDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAG
YGNCIGIPTVGGEVAFDESYAGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNLDNVPQRETEMIPYEMMLSES
QERMVLCVKKGHEQEIIDLFKKYDLDAVNIGEVTDDGFYTLYHKGQMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSE
KYLPEITDSAVSEIFKKLLAQPTIASKKSIYETYDSRVMTNTVVAPGSDAAVLRVRGTNKALAMTTDCNARYLYLDPEKG
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVISGNVSLYNETNGSAILPTPMI
GMVGLIEDVKNITTQEFKKAGDLIVLVGQIFDDFSGSELQKMLTGEISGKIDFDLETEKVNQDFVLKAITDGLINSAHDL
SEGGLAIALAESAFANGLGIDVEVDLSNAQLFSETQGRFVLSISPENQAAFEKLLTESSASSEVIGKVTDNGILKINELS
ISTDEAVSIYEGALPCLMK

Sequences:

>Translated_739_residues
MTLEMSPEQIQESKIYREWGLTDEEYLKIKDEILGGRLPNFTETGMYAVMWSEHCCYKNSKPVLKKFPTTGPQVLMGPGE
GAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGIIRDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAG
YGNCIGIPTVGGEVAFDESYAGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNLDNVPQRETEMIPYEMMLSES
QERMVLCVKKGHEQEIIDLFKKYDLDAVNIGEVTDDGFYTLYHKGQMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSE
KYLPEITDSAVSEIFKKLLAQPTIASKKSIYETYDSRVMTNTVVAPGSDAAVLRVRGTNKALAMTTDCNARYLYLDPEKG
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVISGNVSLYNETNGSAILPTPMI
GMVGLIEDVKNITTQEFKKAGDLIVLVGQIFDDFSGSELQKMLTGEISGKIDFDLETEKVNQDFVLKAITDGLINSAHDL
SEGGLAIALAESAFANGLGIDVEVDLSNAQLFSETQGRFVLSISPENQAAFEKLLTESSASSEVIGKVTDNGILKINELS
ISTDEAVSIYEGALPCLMK
>Mature_738_residues
TLEMSPEQIQESKIYREWGLTDEEYLKIKDEILGGRLPNFTETGMYAVMWSEHCCYKNSKPVLKKFPTTGPQVLMGPGEG
AGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGIIRDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAGY
GNCIGIPTVGGEVAFDESYAGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQR
SAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNLDNVPQRETEMIPYEMMLSESQ
ERMVLCVKKGHEQEIIDLFKKYDLDAVNIGEVTDDGFYTLYHKGQMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSEK
YLPEITDSAVSEIFKKLLAQPTIASKKSIYETYDSRVMTNTVVAPGSDAAVLRVRGTNKALAMTTDCNARYLYLDPEKGG
AIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVISGNVSLYNETNGSAILPTPMIG
MVGLIEDVKNITTQEFKKAGDLIVLVGQIFDDFSGSELQKMLTGEISGKIDFDLETEKVNQDFVLKAITDGLINSAHDLS
EGGLAIALAESAFANGLGIDVEVDLSNAQLFSETQGRFVLSISPENQAAFEKLLTESSASSEVIGKVTDNGILKINELSI
STDEAVSIYEGALPCLMK

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=705, Percent_Identity=23.8297872340426, Blast_Score=96, Evalue=2e-19,
Organism=Escherichia coli, GI48994899, Length=768, Percent_Identity=26.8229166666667, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17553022, Length=448, Percent_Identity=24.3303571428571, Blast_Score=83, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=702, Percent_Identity=24.2165242165242, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79637; Mature: 79506

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEMSPEQIQESKIYREWGLTDEEYLKIKDEILGGRLPNFTETGMYAVMWSEHCCYKNS
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCC
KPVLKKFPTTGPQVLMGPGEGAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHH
RDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAGYGNCIGIPTVGGEVAFDESY
HHHHHCCCCCEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEEECCCC
AGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHH
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHCCHHHHHHHCCCCEEEEC
DNVPQRETEMIPYEMMLSESQERMVLCVKKGHEQEIIDLFKKYDLDAVNIGEVTDDGFYT
CCCCCCHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCEEE
LYHKGQMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSEKYLPEITDSAVSEIFKKLLA
EEECCEEEEECCHHHHHHCCCHHHHHCCCHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHC
QPTIASKKSIYETYDSRVMTNTVVAPGSDAAVLRVRGTNKALAMTTDCNARYLYLDPEKG
CCCCHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCEEEEEECCCCC
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVIS
CEEEHHHHHHHHHHCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCEEE
GNVSLYNETNGSAILPTPMIGMVGLIEDVKNITTQEFKKAGDLIVLVGQIFDDFSGSELQ
CCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHH
KMLTGEISGKIDFDLETEKVNQDFVLKAITDGLINSAHDLSEGGLAIALAESAFANGLGI
HHHHHCCCCEEEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHCCCCCE
DVEVDLSNAQLFSETQGRFVLSISPENQAAFEKLLTESSASSEVIGKVTDNGILKINELS
EEEEECCCCHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEE
ISTDEAVSIYEGALPCLMK
CCCCCHHHHHHCCCHHHCC
>Mature Secondary Structure 
TLEMSPEQIQESKIYREWGLTDEEYLKIKDEILGGRLPNFTETGMYAVMWSEHCCYKNS
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCC
KPVLKKFPTTGPQVLMGPGEGAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHH
RDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAGYGNCIGIPTVGGEVAFDESY
HHHHHCCCCCEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEEECCCC
AGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHH
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHCCHHHHHHHCCCCEEEEC
DNVPQRETEMIPYEMMLSESQERMVLCVKKGHEQEIIDLFKKYDLDAVNIGEVTDDGFYT
CCCCCCHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCEEE
LYHKGQMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSEKYLPEITDSAVSEIFKKLLA
EEECCEEEEECCHHHHHHCCCHHHHHCCCHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHC
QPTIASKKSIYETYDSRVMTNTVVAPGSDAAVLRVRGTNKALAMTTDCNARYLYLDPEKG
CCCCHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCEEEEEECCCCC
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVIS
CEEEHHHHHHHHHHCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCEEE
GNVSLYNETNGSAILPTPMIGMVGLIEDVKNITTQEFKKAGDLIVLVGQIFDDFSGSELQ
CCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHH
KMLTGEISGKIDFDLETEKVNQDFVLKAITDGLINSAHDLSEGGLAIALAESAFANGLGI
HHHHHCCCCEEEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHCCCCCE
DVEVDLSNAQLFSETQGRFVLSISPENQAAFEKLLTESSASSEVIGKVTDNGILKINELS
EEEEECCCCHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEE
ISTDEAVSIYEGALPCLMK
CCCCCHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]