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The map label for this gene is thiL [C]

Identifier: 125623771

GI number: 125623771

Start: 899909

End: 901069

Strand: Direct

Name: thiL [C]

Synonym: llmg_0930

Alternate gene names: 125623771

Gene position: 899909-901069 (Clockwise)

Preceding gene: 125623769

Following gene: 125623772

Centisome position: 35.58

GC content: 38.59

Gene sequence:

>1161_bases
ATGACTTTCGGAGGTTCATTCGTGAAAGAAATTGTAATCATTGACGCCTTAAGAACACCAGTCGGAAAATATGATGGTGC
TCTTGCTGAGTATTCGGCAGAAAAGCTTGGAACACACGTTGTTTCAGCTTTATTGTCAAAAAATAAAAATATAAAATCAG
ATGTTGAACAAGTTATTTTTGGTAATGTTCTTCAAGCTGGTAATGGTCAAAATATTGCGCGCCAAATTGCGATTAATAGT
GGTTTATCAACCAGTGTTCCAGCTTCAACCATTAATGAAGTTTGTGGTTCAGGGATGAAGGCAGTAATTCTAGCTAAGCA
ACTTTTACAGTTGGGCGAAGCAGAAGTTGTTATTGCTGGTGGAACGGAATCAATGTCTAATGCGCCTATTCTTAAAAATC
GTAAAACTGAAGAAGAAACATTAAGCATGTTAAGTGACGGCTTAATTGATGCTTTTTCTGGCATTTCAATGGGAATTATT
GGAGAAACAATTGCGGAGCAGTTTGATGTTAGTCGTGCTGACCAAGACCTATTCGCACAAAATTCTCAAGAGAAGGCAGT
AGCAGCCAGTCAAGCAGGAATTTTTAATGACGAGATCGTAGCTCTTGGGAAACTTACTGTTGATGAAACTCCTCGACCTT
CATCTAGCCTAGAAAAATTGGCTACATTACGGACAGCCTTTAAGGAAAATGGAACAGTTACAGCTGGGAATTCTTCACCA
GTTAATGACGGAGCTTCTGCTTTAATTTTGGCCACTAAAGAGTATGCTGAAAAACATGGAATTTCTTATTTAGCTGAATT
AGTTGAGAGTGCGGAAGTTGGTATTGACCCTGCAATTATGGGAGTATCACCGATTGATGCAATTCAAAAATTAGTTCAAC
GCTCAGGCGTTCAGCTTTCAGAAATAGATCTTTTTGAAATTAATGAGGCCTTTGCTGCATCAAGTATTGCTGTTAATCGT
GAATTGGGCTTAAAAGATTCTCAAGTTAATATTTATGGAGGAGCGATTGCTCTTGGACATGCTATTGGGTCAAGTGGTGC
CAAAATCCTGACAACTTTGGGATATGCTTTGAAACGAGAACAAAAGCGTTATGGAATTGCTAGTCTTTGTATTGGCGGTG
GTCTAGGGCTTGCTATTTTATTGAAAAATCCTGACTTTTAA

Upstream 100 bases:

>100_bases
GCTTTGAATAAATTAAGTCATATAATTCGTCACGTAGTAGACATTTTTCCGCAAATTAATGTAAAGATACTTTGACAAAA
GTAGTTTAAAATATGCTATA

Downstream 100 bases:

>100_bases
AAATTGATGGAGGAATTGCCCAGTATTTCTGGGCATTTTTGGGAAATATGAGAAAAAAATTTTATCAAATGTCGCCACAA
GAGCGATTGAATTCGTTAAA

Product: ThiL protein

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTFGGSFVKEIVIIDALRTPVGKYDGALAEYSAEKLGTHVVSALLSKNKNIKSDVEQVIFGNVLQAGNGQNIARQIAINS
GLSTSVPASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSNAPILKNRKTEEETLSMLSDGLIDAFSGISMGII
GETIAEQFDVSRADQDLFAQNSQEKAVAASQAGIFNDEIVALGKLTVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSP
VNDGASALILATKEYAEKHGISYLAELVESAEVGIDPAIMGVSPIDAIQKLVQRSGVQLSEIDLFEINEAFAASSIAVNR
ELGLKDSQVNIYGGAIALGHAIGSSGAKILTTLGYALKREQKRYGIASLCIGGGLGLAILLKNPDF

Sequences:

>Translated_386_residues
MTFGGSFVKEIVIIDALRTPVGKYDGALAEYSAEKLGTHVVSALLSKNKNIKSDVEQVIFGNVLQAGNGQNIARQIAINS
GLSTSVPASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSNAPILKNRKTEEETLSMLSDGLIDAFSGISMGII
GETIAEQFDVSRADQDLFAQNSQEKAVAASQAGIFNDEIVALGKLTVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSP
VNDGASALILATKEYAEKHGISYLAELVESAEVGIDPAIMGVSPIDAIQKLVQRSGVQLSEIDLFEINEAFAASSIAVNR
ELGLKDSQVNIYGGAIALGHAIGSSGAKILTTLGYALKREQKRYGIASLCIGGGLGLAILLKNPDF
>Mature_385_residues
TFGGSFVKEIVIIDALRTPVGKYDGALAEYSAEKLGTHVVSALLSKNKNIKSDVEQVIFGNVLQAGNGQNIARQIAINSG
LSTSVPASTINEVCGSGMKAVILAKQLLQLGEAEVVIAGGTESMSNAPILKNRKTEEETLSMLSDGLIDAFSGISMGIIG
ETIAEQFDVSRADQDLFAQNSQEKAVAASQAGIFNDEIVALGKLTVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSPV
NDGASALILATKEYAEKHGISYLAELVESAEVGIDPAIMGVSPIDAIQKLVQRSGVQLSEIDLFEINEAFAASSIAVNRE
LGLKDSQVNIYGGAIALGHAIGSSGAKILTTLGYALKREQKRYGIASLCIGGGLGLAILLKNPDF

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.4730077120823, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI167614485, Length=394, Percent_Identity=39.0862944162437, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=39.1304347826087, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=38.3631713554987, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=30.4964539007092, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI194353979, Length=242, Percent_Identity=31.404958677686, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=46.0358056265985, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=45.0127877237852, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=37.75, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=36.6583541147132, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=29.5673076923077, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=40.4580152671756, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI25147385, Length=378, Percent_Identity=35.978835978836, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=35.9897172236504, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=419, Percent_Identity=31.980906921241, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=376, Percent_Identity=31.1170212765957, Blast_Score=158, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=38.9873417721519, Blast_Score=262, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=36.6666666666667, Blast_Score=227, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24655093, Length=386, Percent_Identity=44.0414507772021, Blast_Score=311, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=39.5408163265306, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=38.3631713554987, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=31.042654028436, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40330; Mature: 40199

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFGGSFVKEIVIIDALRTPVGKYDGALAEYSAEKLGTHVVSALLSKNKNIKSDVEQVIF
CCCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GNVLQAGNGQNIARQIAINSGLSTSVPASTINEVCGSGMKAVILAKQLLQLGEAEVVIAG
HHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEC
GTESMSNAPILKNRKTEEETLSMLSDGLIDAFSGISMGIIGETIAEQFDVSRADQDLFAQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHC
NSQEKAVAASQAGIFNDEIVALGKLTVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSP
CCHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCC
VNDGASALILATKEYAEKHGISYLAELVESAEVGIDPAIMGVSPIDAIQKLVQRSGVQLS
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHCCCEEE
EIDLFEINEAFAASSIAVNRELGLKDSQVNIYGGAIALGHAIGSSGAKILTTLGYALKRE
EECHHHHHHHHHHHHHEECCCCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHH
QKRYGIASLCIGGGLGLAILLKNPDF
HHHCCHHHHHHCCCCEEEEEEECCCC
>Mature Secondary Structure 
TFGGSFVKEIVIIDALRTPVGKYDGALAEYSAEKLGTHVVSALLSKNKNIKSDVEQVIF
CCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GNVLQAGNGQNIARQIAINSGLSTSVPASTINEVCGSGMKAVILAKQLLQLGEAEVVIAG
HHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEC
GTESMSNAPILKNRKTEEETLSMLSDGLIDAFSGISMGIIGETIAEQFDVSRADQDLFAQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHC
NSQEKAVAASQAGIFNDEIVALGKLTVDETPRPSSSLEKLATLRTAFKENGTVTAGNSSP
CCHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCC
VNDGASALILATKEYAEKHGISYLAELVESAEVGIDPAIMGVSPIDAIQKLVQRSGVQLS
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHCCCEEE
EIDLFEINEAFAASSIAVNRELGLKDSQVNIYGGAIALGHAIGSSGAKILTTLGYALKRE
EECHHHHHHHHHHHHHEECCCCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHH
QKRYGIASLCIGGGLGLAILLKNPDF
HHHCCHHHHHHCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA