Click here to switch to the map view.

The map label for this gene is nagB [H]

Identifier: 125623769

GI number: 125623769

Start: 897703

End: 898410

Strand: Direct

Name: nagB [H]

Synonym: llmg_0928

Alternate gene names: 125623769

Gene position: 897703-898410 (Clockwise)

Preceding gene: 125623768

Following gene: 125623771

Centisome position: 35.49

GC content: 35.17

Gene sequence:

>708_bases
ATGAAAGTTATCGTAGTAAAAAACCAACTTGAAGGTGGAAAAATCGGACTTGATCTTCTTAAAGAATCAATCAACAATGG
TGCAAAAACATTGGGACTTGCGACAGGTTCAACACCAGTAGAATTTTATAATCAAATCGTTAATTCAGACCTTGATTTTA
CAAACATGGTATCAGTAAACTTGGACGAATATGTAGGGCTTGATGGTTCTAATGAACAATCATATCGTTACTTTATGACT
AAACATTTGTTTGGAGAAAAACCATTTAAAGAAAACTTCTTGCCAAATGGTAAAGCAACTGACCTTGAAGCTGAAGCAAA
ACATTATGACCAAATTATTGAAGAAAACCCAATTGATTGGCAAATTCTTGGAATTGGTCAAAATGGACACATTGGTTTTA
ATGAACCTGGAACACCAGCTGAAATTACAACTCATGTTGTAGACCTTCAAGAAAGCACAATCAAAGCTAACGCTCGTTTC
TTTGAATCAGAAGCAGATGTTCCACGTAAAGCAATTTCAATGGGGCTTGCATCAATTATGAAATCTAAAAACATTGTTTT
AATGGCTTACGGAAAAGAAAAAGCAGAAGCAATTAAAGGAATGGTTGAAGGTGAAGTGACTACTGAACTTCCAGCATCAA
TTTTGCAAAACCATGCGAATGTTACTGTTATTGCTGACGAAGCTGCGGTATCATTGTTGAGCAAATAA

Upstream 100 bases:

>100_bases
ATTTTTGAAGACAATTTTTAGTTGACATGGTCTTATTTTATGATATAATGAAAGTGTAGAAAAATTGATATATACCAATT
TAGGAATGGAGCATATAAAA

Downstream 100 bases:

>100_bases
AATAAAAAAAGTCCTATCAGGACTTTTTAATTTACTGACAGAAAAGCTGTCAGTATTTTTTTATATTTTTTTATATTTAC
GATGGTTATCAACGACTTCT

Product: glucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKVIVVKNQLEGGKIGLDLLKESINNGAKTLGLATGSTPVEFYNQIVNSDLDFTNMVSVNLDEYVGLDGSNEQSYRYFMT
KHLFGEKPFKENFLPNGKATDLEAEAKHYDQIIEENPIDWQILGIGQNGHIGFNEPGTPAEITTHVVDLQESTIKANARF
FESEADVPRKAISMGLASIMKSKNIVLMAYGKEKAEAIKGMVEGEVTTELPASILQNHANVTVIADEAAVSLLSK

Sequences:

>Translated_235_residues
MKVIVVKNQLEGGKIGLDLLKESINNGAKTLGLATGSTPVEFYNQIVNSDLDFTNMVSVNLDEYVGLDGSNEQSYRYFMT
KHLFGEKPFKENFLPNGKATDLEAEAKHYDQIIEENPIDWQILGIGQNGHIGFNEPGTPAEITTHVVDLQESTIKANARF
FESEADVPRKAISMGLASIMKSKNIVLMAYGKEKAEAIKGMVEGEVTTELPASILQNHANVTVIADEAAVSLLSK
>Mature_235_residues
MKVIVVKNQLEGGKIGLDLLKESINNGAKTLGLATGSTPVEFYNQIVNSDLDFTNMVSVNLDEYVGLDGSNEQSYRYFMT
KHLFGEKPFKENFLPNGKATDLEAEAKHYDQIIEENPIDWQILGIGQNGHIGFNEPGTPAEITTHVVDLQESTIKANARF
FESEADVPRKAISMGLASIMKSKNIVLMAYGKEKAEAIKGMVEGEVTTELPASILQNHANVTVIADEAAVSLLSK

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI13027378, Length=244, Percent_Identity=33.6065573770492, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI19923881, Length=208, Percent_Identity=34.1346153846154, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1786893, Length=207, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789530, Length=200, Percent_Identity=26.5, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI48994958, Length=237, Percent_Identity=25.3164556962025, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17554876, Length=223, Percent_Identity=35.8744394618834, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24581960, Length=244, Percent_Identity=34.4262295081967, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19920764, Length=244, Percent_Identity=34.4262295081967, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 25689; Mature: 25689

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIVVKNQLEGGKIGLDLLKESINNGAKTLGLATGSTPVEFYNQIVNSDLDFTNMVSVN
CEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEEC
LDEYVGLDGSNEQSYRYFMTKHLFGEKPFKENFLPNGKATDLEAEAKHYDQIIEENPIDW
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
QILGIGQNGHIGFNEPGTPAEITTHVVDLQESTIKANARFFESEADVPRKAISMGLASIM
EEEEECCCCCCCCCCCCCCHHHHHEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KSKNIVLMAYGKEKAEAIKGMVEGEVTTELPASILQNHANVTVIADEAAVSLLSK
CCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHCC
>Mature Secondary Structure
MKVIVVKNQLEGGKIGLDLLKESINNGAKTLGLATGSTPVEFYNQIVNSDLDFTNMVSVN
CEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEEC
LDEYVGLDGSNEQSYRYFMTKHLFGEKPFKENFLPNGKATDLEAEAKHYDQIIEENPIDW
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
QILGIGQNGHIGFNEPGTPAEITTHVVDLQESTIKANARFFESEADVPRKAISMGLASIM
EEEEECCCCCCCCCCCCCCHHHHHEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KSKNIVLMAYGKEKAEAIKGMVEGEVTTELPASILQNHANVTVIADEAAVSLLSK
CCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]