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The map label for this gene is mvaA [H]

Identifier: 125623772

GI number: 125623772

Start: 901117

End: 902349

Strand: Direct

Name: mvaA [H]

Synonym: llmg_0931

Alternate gene names: 125623772

Gene position: 901117-902349 (Clockwise)

Preceding gene: 125623771

Following gene: 125623773

Centisome position: 35.62

GC content: 37.88

Gene sequence:

>1233_bases
ATGAGAAAAAAATTTTATCAAATGTCGCCACAAGAGCGATTGAATTCGTTAAACTTATCCGAAAAGAGTCAAGAAATTTT
AAGTGAGATGGCCCTAGATACAACTATTTTGGACAATCTCATAGAAAATCAAATTTCTGAATTTGAATTGCCAATGGGAA
TTGCCCAAAATTTTGTTATTAATGGACAAAGTTTTCTAATACCAATGGTTACAGAGGAACCGTCAGTAATTGCCGCAGCA
AGTAATGGAGCAAAAATAGCTGGAAATTTTGTAGCTGAAATTAAAGAACGTTTAATGCGTGGTCAAATTGTATTTTATGA
TGTTAAAAATTCAGATAAGATTGCAAATGAAATACTTGAAAAGCAAGAAAAAATCTTTGAACAAGCCGAACTTTCTTACC
CTTCAATCGTTAAACGAGGTGGCGGTTTGAGAGAGGTTTCTAGTCGGATTTTCTCTAGTCAAAAGTTTTTATCTGTTGAT
GTCAAGGTTGATGTTAAAGACGCCATGGGTGCAAATATTATTAATTCAATCTTAGAGGGAATTGCTGAACTCTTTCGGAG
GTGGTTTCCTGATGAAAAAATTCTGTTTAGTATTTTATCAAATTATGCTACTGAATCACTAGTGAAAGTGACCTGTGAAA
TTCCGGTTGAACGCCTTTCAAAAAAAGCAGATGGATATGAAATTGGTCAAAAAATTATGGCTGCTTCCCAATATTCAAAA
ATTGATCCTTATCGTGCTAGCACCCATAACAAAGGGATTATGAACGGTATCAATGCGGTCATTTTAGCTACAGGAAATGA
TACTCGGGCCATCTCAGCTGCTATTCATGCTTATGCGGCAAAAGATGGAGCCTACCAAGGGTTAGCCAACTGGGAACTTC
AAGAGAAAATGTTAGTTGGCGAACTCGAATTTCCTTTACCAGTGGCAACTGTCGGAGGGGGAGTCAAGGTTTTGCCAAAA
GCACAAGCGGCCATGGAGATTCTGGGTATCAGTGATGCTAAGGAGCTCGCAAAAGTTATTGCTGCAGTGGGACTAGCTCA
AAACTTAGCCGCTTTACGTGCCCTAGTTTCAGAAGGAATTCAACAGGGACACATGAGTCTACAAGCTCGTTCTTTGGCTT
TGAGTGTAGGAGCACAAGCGGATGAAATCGCGATATTAAGTCAACAATTGCGCAAAGAAAAAGTGATGAATCAAGAAGTA
GCCCAAAATTTACTAAAAAATTTGAGAAAATAA

Upstream 100 bases:

>100_bases
GTATTGGCGGTGGTCTAGGGCTTGCTATTTTATTGAAAAATCCTGACTTTTAAAAATTGATGGAGGAATTGCCCAGTATT
TCTGGGCATTTTTGGGAAAT

Downstream 100 bases:

>100_bases
TAGCCTGTCAAGATTTTTTCTTGACAGCATGAAATTAGTCTGCTATAATATTAAATATAATAAAAAAGAAATAGGAAATA
TAAAATGTCTGTAAAAATTC

Product: MvaA protein

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRKKFYQMSPQERLNSLNLSEKSQEILSEMALDTTILDNLIENQISEFELPMGIAQNFVINGQSFLIPMVTEEPSVIAAA
SNGAKIAGNFVAEIKERLMRGQIVFYDVKNSDKIANEILEKQEKIFEQAELSYPSIVKRGGGLREVSSRIFSSQKFLSVD
VKVDVKDAMGANIINSILEGIAELFRRWFPDEKILFSILSNYATESLVKVTCEIPVERLSKKADGYEIGQKIMAASQYSK
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKDGAYQGLANWELQEKMLVGELEFPLPVATVGGGVKVLPK
AQAAMEILGISDAKELAKVIAAVGLAQNLAALRALVSEGIQQGHMSLQARSLALSVGAQADEIAILSQQLRKEKVMNQEV
AQNLLKNLRK

Sequences:

>Translated_410_residues
MRKKFYQMSPQERLNSLNLSEKSQEILSEMALDTTILDNLIENQISEFELPMGIAQNFVINGQSFLIPMVTEEPSVIAAA
SNGAKIAGNFVAEIKERLMRGQIVFYDVKNSDKIANEILEKQEKIFEQAELSYPSIVKRGGGLREVSSRIFSSQKFLSVD
VKVDVKDAMGANIINSILEGIAELFRRWFPDEKILFSILSNYATESLVKVTCEIPVERLSKKADGYEIGQKIMAASQYSK
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKDGAYQGLANWELQEKMLVGELEFPLPVATVGGGVKVLPK
AQAAMEILGISDAKELAKVIAAVGLAQNLAALRALVSEGIQQGHMSLQARSLALSVGAQADEIAILSQQLRKEKVMNQEV
AQNLLKNLRK
>Mature_410_residues
MRKKFYQMSPQERLNSLNLSEKSQEILSEMALDTTILDNLIENQISEFELPMGIAQNFVINGQSFLIPMVTEEPSVIAAA
SNGAKIAGNFVAEIKERLMRGQIVFYDVKNSDKIANEILEKQEKIFEQAELSYPSIVKRGGGLREVSSRIFSSQKFLSVD
VKVDVKDAMGANIINSILEGIAELFRRWFPDEKILFSILSNYATESLVKVTCEIPVERLSKKADGYEIGQKIMAASQYSK
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKDGAYQGLANWELQEKMLVGELEFPLPVATVGGGVKVLPK
AQAAMEILGISDAKELAKVIAAVGLAQNLAALRALVSEGIQQGHMSLQARSLALSVGAQADEIAILSQQLRKEKVMNQEV
AQNLLKNLRK

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 44945; Mature: 44945

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKFYQMSPQERLNSLNLSEKSQEILSEMALDTTILDNLIENQISEFELPMGIAQNFVI
CCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEE
NGQSFLIPMVTEEPSVIAAASNGAKIAGNFVAEIKERLMRGQIVFYDVKNSDKIANEILE
CCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
KQEKIFEQAELSYPSIVKRGGGLREVSSRIFSSQKFLSVDVKVDVKDAMGANIINSILEG
HHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEECHHHCCHHHHHHHHHH
IAELFRRWFPDEKILFSILSNYATESLVKVTCEIPVERLSKKADGYEIGQKIMAASQYSK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHCC
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKDGAYQGLANWELQEKMLVG
CCCCCCCCCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
ELEFPLPVATVGGGVKVLPKAQAAMEILGISDAKELAKVIAAVGLAQNLAALRALVSEGI
CCCCCCCCEECCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQGHMSLQARSLALSVGAQADEIAILSQQLRKEKVMNQEVAQNLLKNLRK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKKFYQMSPQERLNSLNLSEKSQEILSEMALDTTILDNLIENQISEFELPMGIAQNFVI
CCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEE
NGQSFLIPMVTEEPSVIAAASNGAKIAGNFVAEIKERLMRGQIVFYDVKNSDKIANEILE
CCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
KQEKIFEQAELSYPSIVKRGGGLREVSSRIFSSQKFLSVDVKVDVKDAMGANIINSILEG
HHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEECHHHCCHHHHHHHHHH
IAELFRRWFPDEKILFSILSNYATESLVKVTCEIPVERLSKKADGYEIGQKIMAASQYSK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHCC
IDPYRASTHNKGIMNGINAVILATGNDTRAISAAIHAYAAKDGAYQGLANWELQEKMLVG
CCCCCCCCCCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
ELEFPLPVATVGGGVKVLPKAQAAMEILGISDAKELAKVIAAVGLAQNLAALRALVSEGI
CCCCCCCCEECCCCEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQGHMSLQARSLALSVGAQADEIAILSQQLRKEKVMNQEVAQNLLKNLRK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]