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The map label for this gene is serC

Identifier: 125623430

GI number: 125623430

Start: 557905

End: 559002

Strand: Direct

Name: serC

Synonym: llmg_0565

Alternate gene names: 125623430

Gene position: 557905-559002 (Clockwise)

Preceding gene: 125623429

Following gene: 125623431

Centisome position: 22.06

GC content: 34.7

Gene sequence:

>1098_bases
ATGATTTATAATTTTGGTGCAGGACCTAGTGTACTTCCAAAGGAAGTTTTGAAAAAAGTTCAAGAAGAACTGTTAGACTT
TGAAAAAAGCGGTATGTCAGTGATGGAAATTTCACATCGATCCAAATCTTTTCAAGAGGTCATTGATGAGGCGCAAAATA
ATTTGCGCGACTTGATGTCCATTCCTCAAAACTATAAAATATTATTTTTACAAGGCGGGGCTTCCACTCAATTCTCAATG
ATTCCAATGAATTTGGCTCTTGGGAAAAAAGCTTATTATGCAATCTCAGGGGCCTTTGGAAAAAAGGCTTATGATGAGGC
AGTAAAATTGAGTCAGACCTTAGATTTTGAAGCAATCAGTTTGGGTTCAACTCAATCAGAATATTATAATCATCTTTTGA
AAATTGATACGTCCAAAGTTGATGAGAAAATGGCAGCTTATTTGCATATAACAACAAATAATACTATTGAAGGAACGACT
ATTTTTCCAGAAAATCTACCAGAAGTTAATTCTGTTCCTTTAATTGCTGATATGAGTTCAAATATTTTGGCAGTTGATTA
TGATGTGAGTAAATTTGGTTTAATTTATGCTGGAGCTCAAAAAAATCTAGGGATTGCCGGTTTGACAATTGTCATTATTC
GTGAAGATTTATTGAATCAAAAAGAAAGTCTTTCATCAATGATGGACTACCGTATTTTGGCTCAGAATGGCTCTATGTAT
AATACACCACCAACTTTTGCTATTTATTTGGCTGGTTTGGTATTCAAATGGGTCAAAGAACAGGGCGGAGTTAAAAAACT
TGAAGCAATAAATCACCAAAAAGCTCGGATGCTTTATGATTTAATTGACCAGTCGGATTTTTATCAGAGCCCAGTTCTAA
ATAAAGTAGAGCGGTCGATATGTAATGTTGTCTTTACCAGTCCAAGTAAGGAATTGGATGCTTTATTTGTGCAAAAAGCC
GAAGAAAAAGGTTTTAAATCAATCAAAGGCCATCGTTCGGTTGGAGGAATGCGAGCAAGTATCTACAACGCTTTTCCAAT
AGAAGGTGTGCTTGAATTGGTTAAATTTATGAAGAAATTTGAAGAGGAAAATAAATGA

Upstream 100 bases:

>100_bases
CATTGATGTGATTTTTGTCGAACAGTATTTTTTTATATTTGAATTATCAGAAAATTATATTATAATAGTGTTTAATAAAT
AATTTGAGGAAGTGAAATCG

Downstream 100 bases:

>100_bases
CTTATCAGATTAAAACAATAGGAAATAATATTGACCAAGTTGCTCTGGATGAAGTTGTCGAACAATTTGCTATCAATCAA
GTACCAGAAAACAAAGCGGA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKSFQEVIDEAQNNLRDLMSIPQNYKILFLQGGASTQFSM
IPMNLALGKKAYYAISGAFGKKAYDEAVKLSQTLDFEAISLGSTQSEYYNHLLKIDTSKVDEKMAAYLHITTNNTIEGTT
IFPENLPEVNSVPLIADMSSNILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNQKESLSSMMDYRILAQNGSMY
NTPPTFAIYLAGLVFKWVKEQGGVKKLEAINHQKARMLYDLIDQSDFYQSPVLNKVERSICNVVFTSPSKELDALFVQKA
EEKGFKSIKGHRSVGGMRASIYNAFPIEGVLELVKFMKKFEEENK

Sequences:

>Translated_365_residues
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKSFQEVIDEAQNNLRDLMSIPQNYKILFLQGGASTQFSM
IPMNLALGKKAYYAISGAFGKKAYDEAVKLSQTLDFEAISLGSTQSEYYNHLLKIDTSKVDEKMAAYLHITTNNTIEGTT
IFPENLPEVNSVPLIADMSSNILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNQKESLSSMMDYRILAQNGSMY
NTPPTFAIYLAGLVFKWVKEQGGVKKLEAINHQKARMLYDLIDQSDFYQSPVLNKVERSICNVVFTSPSKELDALFVQKA
EEKGFKSIKGHRSVGGMRASIYNAFPIEGVLELVKFMKKFEEENK
>Mature_365_residues
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKSFQEVIDEAQNNLRDLMSIPQNYKILFLQGGASTQFSM
IPMNLALGKKAYYAISGAFGKKAYDEAVKLSQTLDFEAISLGSTQSEYYNHLLKIDTSKVDEKMAAYLHITTNNTIEGTT
IFPENLPEVNSVPLIADMSSNILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNQKESLSSMMDYRILAQNGSMY
NTPPTFAIYLAGLVFKWVKEQGGVKKLEAINHQKARMLYDLIDQSDFYQSPVLNKVERSICNVVFTSPSKELDALFVQKA
EEKGFKSIKGHRSVGGMRASIYNAFPIEGVLELVKFMKKFEEENK

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=370, Percent_Identity=43.7837837837838, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI10863955, Length=365, Percent_Identity=39.1780821917808, Blast_Score=258, Evalue=5e-69,
Organism=Escherichia coli, GI1787136, Length=368, Percent_Identity=47.2826086956522, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17506897, Length=368, Percent_Identity=42.1195652173913, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6324758, Length=392, Percent_Identity=36.734693877551, Blast_Score=246, Evalue=3e-66,
Organism=Drosophila melanogaster, GI21356589, Length=374, Percent_Identity=43.048128342246, Blast_Score=290, Evalue=9e-79,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_LACLM (A2RIS2)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001031913.1
- ProteinModelPortal:   A2RIS2
- SMR:   A2RIS2
- STRING:   A2RIS2
- GeneID:   4797974
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_0565
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40850; Mature: 40850

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 40-40 BINDING 99-99 BINDING 155-155 BINDING 177-177 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKSFQEVIDEAQNNLRDLMS
CEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPQNYKILFLQGGASTQFSMIPMNLALGKKAYYAISGAFGKKAYDEAVKLSQTLDFEAIS
CCCCCEEEEEECCCCCEEEEEEEHHHHCCCCEEEEECHHCCHHHHHHHHHHHHCCCCEEE
LGSTQSEYYNHLLKIDTSKVDEKMAAYLHITTNNTIEGTTIFPENLPEVNSVPLIADMSS
CCCCHHHHHHHHHHCCHHHHHHHHEEEEEEEECCEECCCEECCCCCCCCCCCCEEEECCC
NILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNQKESLSSMMDYRILAQNGSMY
CEEEEECCHHHCEEEEECCCCCCCEEHEEEEEEEHHHHCHHHHHHHHHHHEEEECCCCCC
NTPPTFAIYLAGLVFKWVKEQGGVKKLEAINHQKARMLYDLIDQSDFYQSPVLNKVERSI
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHH
CNVVFTSPSKELDALFVQKAEEKGFKSIKGHRSVGGMRASIYNAFPIEGVLELVKFMKKF
HHEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCHHHHHHHHHHHHHH
EEENK
HHCCC
>Mature Secondary Structure
MIYNFGAGPSVLPKEVLKKVQEELLDFEKSGMSVMEISHRSKSFQEVIDEAQNNLRDLMS
CEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPQNYKILFLQGGASTQFSMIPMNLALGKKAYYAISGAFGKKAYDEAVKLSQTLDFEAIS
CCCCCEEEEEECCCCCEEEEEEEHHHHCCCCEEEEECHHCCHHHHHHHHHHHHCCCCEEE
LGSTQSEYYNHLLKIDTSKVDEKMAAYLHITTNNTIEGTTIFPENLPEVNSVPLIADMSS
CCCCHHHHHHHHHHCCHHHHHHHHEEEEEEEECCEECCCEECCCCCCCCCCCCEEEECCC
NILAVDYDVSKFGLIYAGAQKNLGIAGLTIVIIREDLLNQKESLSSMMDYRILAQNGSMY
CEEEEECCHHHCEEEEECCCCCCCEEHEEEEEEEHHHHCHHHHHHHHHHHEEEECCCCCC
NTPPTFAIYLAGLVFKWVKEQGGVKKLEAINHQKARMLYDLIDQSDFYQSPVLNKVERSI
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHH
CNVVFTSPSKELDALFVQKAEEKGFKSIKGHRSVGGMRASIYNAFPIEGVLELVKFMKKF
HHEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCHHHHHHHHHHHHHH
EEENK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA