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The map label for this gene is serA [H]

Identifier: 125623431

GI number: 125623431

Start: 558999

End: 560195

Strand: Direct

Name: serA [H]

Synonym: llmg_0566

Alternate gene names: 125623431

Gene position: 558999-560195 (Clockwise)

Preceding gene: 125623430

Following gene: 125623432

Centisome position: 22.1

GC content: 37.18

Gene sequence:

>1197_bases
ATGACTTATCAGATTAAAACAATAGGAAATAATATTGACCAAGTTGCTCTGGATGAAGTTGTCGAACAATTTGCTATCAA
TCAAGTACCAGAAAACAAAGCGGACGCTTTTATTTGTCGTGCCCAACCTTTTCATGATTATGAATTTTCAAAAGAACTGT
TGGCCATTGGACGTGCAGGGGCTGGATTTAATAATATCCCGATTGAAAAATGCGCAAGCAAAGGAATTGTTGTCTTTAAT
GCCCCTGGTGGGAATGCTAATGCGGTCAAAGAGTTGGTCTTGTCAATGATGATTTTTGGGACCCGTAATTTGAAACCTGC
CAATAAATGGCTGACAGGACAAAAAGGAAATGATAAGGCTATTGACGTTGCAGTTGAAAATGGGAAAAAAGCATTTTCTG
GTTCAGAAATTTCTGGAAAAACTTTAGGTGTGATTGGTCTTGGAAATATTGGCTCAAAAGTTGCTAATGATGCACAGCGT
TTAGGGATGAAAGTGATTGGTTATGACCCATATCTCTCAATTGAGCATGCTTGGAATTTGTCACATCATGTCAAACGGGT
CAATGATTTGTCAGAAATTTTTGAGAAAGCAGATTATATTACGGTTCACACGCCAGCGACTGATGAAACAAAGGGAATGC
TTAATTGGAAAAATTTATCAAAATGTAAAAATGGAGTGATTTTGCTGAATTATGCTCGAGATGAGATTTCAGATAAAGAA
GCCATTCTTAAGGCGATTGATGAAGGGATTGTTCGTTTCTTTGGCACCGATTTTGGTTCTGAAAAATTTTATCATCACCC
TCAAGTTTTTTTGACTCCTCATTTAGGGGGCTCAACAGCAGAAGCCAGCTTAAATTGTACTCGGATGGCGCTTGATTCTG
TTCAAACCTATTTGAAAACGGGTGAGATTATTAATTCAGTCAACTTTCCGCGTGTTTTGCAAGAGTTAAATACGCCTTAT
CGTGTGACCTTAATCAATAAAAATGTGCCAAATGTTGTGGCGCAAATTTCTTTAGCAGTTGCCGAAGAAAATATTAATAT
CGCTAACATTGTCAATCGCGGTCAAGGGGATTTTGCTTATACATTACTTGATTTAGATGAAAAAGACGAAAGAAAATTGG
CGGCTTTGGTTTCGCGTTTTGAAGCTTCTGAAAATATTGTGCGTGTACGTTTAATTGAAAATCCAAATTTATTTTAA

Upstream 100 bases:

>100_bases
GTTCGGTTGGAGGAATGCGAGCAAGTATCTACAACGCTTTTCCAATAGAAGGTGTGCTTGAATTGGTTAAATTTATGAAG
AAATTTGAAGAGGAAAATAA

Downstream 100 bases:

>100_bases
ATTTGATCATAAATATTTTTGAAAGACAAGTAGGATAGAGGAAAAATGACAGTAAAAGGATTACTTGTGATGGATGTCGA
TAGCACCTTGATTGAGGAGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTYQIKTIGNNIDQVALDEVVEQFAINQVPENKADAFICRAQPFHDYEFSKELLAIGRAGAGFNNIPIEKCASKGIVVFN
APGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGNDKAIDVAVENGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQR
LGMKVIGYDPYLSIEHAWNLSHHVKRVNDLSEIFEKADYITVHTPATDETKGMLNWKNLSKCKNGVILLNYARDEISDKE
AILKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTPY
RVTLINKNVPNVVAQISLAVAEENINIANIVNRGQGDFAYTLLDLDEKDERKLAALVSRFEASENIVRVRLIENPNLF

Sequences:

>Translated_398_residues
MTYQIKTIGNNIDQVALDEVVEQFAINQVPENKADAFICRAQPFHDYEFSKELLAIGRAGAGFNNIPIEKCASKGIVVFN
APGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGNDKAIDVAVENGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQR
LGMKVIGYDPYLSIEHAWNLSHHVKRVNDLSEIFEKADYITVHTPATDETKGMLNWKNLSKCKNGVILLNYARDEISDKE
AILKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTPY
RVTLINKNVPNVVAQISLAVAEENINIANIVNRGQGDFAYTLLDLDEKDERKLAALVSRFEASENIVRVRLIENPNLF
>Mature_397_residues
TYQIKTIGNNIDQVALDEVVEQFAINQVPENKADAFICRAQPFHDYEFSKELLAIGRAGAGFNNIPIEKCASKGIVVFNA
PGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGNDKAIDVAVENGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQRL
GMKVIGYDPYLSIEHAWNLSHHVKRVNDLSEIFEKADYITVHTPATDETKGMLNWKNLSKCKNGVILLNYARDEISDKEA
ILKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKTGEIINSVNFPRVLQELNTPYR
VTLINKNVPNVVAQISLAVAEENINIANIVNRGQGDFAYTLLDLDEKDERKLAALVSRFEASENIVRVRLIENPNLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=243, Percent_Identity=37.4485596707819, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=30.03663003663, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=30.03663003663, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI145580578, Length=271, Percent_Identity=30.6273062730627, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557499, Length=271, Percent_Identity=30.6273062730627, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI145580575, Length=272, Percent_Identity=30.5147058823529, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1789279, Length=354, Percent_Identity=30.5084745762712, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787645, Length=197, Percent_Identity=30.4568527918782, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082289, Length=283, Percent_Identity=22.6148409893993, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=295, Percent_Identity=33.5593220338983, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=212, Percent_Identity=27.3584905660377, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=372, Percent_Identity=27.9569892473118, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6320925, Length=372, Percent_Identity=27.9569892473118, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=263, Percent_Identity=24.3346007604563, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921140, Length=281, Percent_Identity=34.8754448398576, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=28.8702928870293, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=28.8702928870293, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=28.8702928870293, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=28.8702928870293, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=28.8702928870293, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574286, Length=246, Percent_Identity=21.5447154471545, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43914; Mature: 43782

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQIKTIGNNIDQVALDEVVEQFAINQVPENKADAFICRAQPFHDYEFSKELLAIGRAG
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCC
AGFNNIPIEKCASKGIVVFNAPGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGNDKA
CCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCE
IDVAVENGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQRLGMKVIGYDPYLSIEHAWNL
EEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCEEEECCCCEEEEHHHCCH
SHHVKRVNDLSEIFEKADYITVHTPATDETKGMLNWKNLSKCKNGVILLNYARDEISDKE
HHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHH
AILKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKT
HHHHHHHHHHHHHHCCCCCCCCCEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
GEIINSVNFPRVLQELNTPYRVTLINKNVPNVVAQISLAVAEENINIANIVNRGQGDFAY
HHHHHCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHEEECCCCCHHHHHCCCCCCEEE
TLLDLDEKDERKLAALVSRFEASENIVRVRLIENPNLF
EEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TYQIKTIGNNIDQVALDEVVEQFAINQVPENKADAFICRAQPFHDYEFSKELLAIGRAG
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCC
AGFNNIPIEKCASKGIVVFNAPGGNANAVKELVLSMMIFGTRNLKPANKWLTGQKGNDKA
CCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCE
IDVAVENGKKAFSGSEISGKTLGVIGLGNIGSKVANDAQRLGMKVIGYDPYLSIEHAWNL
EEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCEEEECCCCEEEEHHHCCH
SHHVKRVNDLSEIFEKADYITVHTPATDETKGMLNWKNLSKCKNGVILLNYARDEISDKE
HHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHH
AILKAIDEGIVRFFGTDFGSEKFYHHPQVFLTPHLGGSTAEASLNCTRMALDSVQTYLKT
HHHHHHHHHHHHHHCCCCCCCCCEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
GEIINSVNFPRVLQELNTPYRVTLINKNVPNVVAQISLAVAEENINIANIVNRGQGDFAY
HHHHHCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHEEECCCCCHHHHHCCCCCCEEE
TLLDLDEKDERKLAALVSRFEASENIVRVRLIENPNLF
EEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]