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The map label for this gene is groEL [H]

Identifier: 125623278

GI number: 125623278

Start: 404132

End: 405760

Strand: Direct

Name: groEL [H]

Synonym: llmg_0411

Alternate gene names: 125623278

Gene position: 404132-405760 (Clockwise)

Preceding gene: 125623277

Following gene: 125623282

Centisome position: 15.98

GC content: 39.9

Gene sequence:

>1629_bases
ATGTCAAAAGAAATTAAATTTTCAAGTGATGCTAGAACAGCGATGATGCGCGGAATTGATATTCTTGCCGATACAGTAAA
AACAACCCTTGGGCCAAAAGGGCGTAATGTTGTTCTTGAAAAATCATATGGTTCACCTTTAATTACAAATGATGGTGTTA
CAATTGCCAAAGAGATTGAACTTGAAGACCATTTTGAAAATATGGGAGCTAAACTTGTTTCGGAAGTTGCTTCAAAAACA
AATGATATTGCAGGTGATGGAACAACAACAGCGACAGTTTTGACACAAGCTATTGTTCGTGAAGGATTGAAAAATGTTAC
TGCAGGTGCAAATCCAGTTGGTATTCGCCGAGGAATTGAACTCGCAGCTGAAACAGCAGTTGCTTCAATTAAAGAAATGG
CAATTCCTGTTCACGATAAATCAGCAATCGCTCAAGTTGCTACCGTTTCATCACGTAGTGAAAAAGTTGGGGAATATATT
TCTGACGCAATGGAGCGTGTAGGTTCTGACGGAGTTATCACAATCGAAGAATCAAAAGGAATGCAAACAGAGCTTGATGT
TGTTGAAGGAATGCAATTTGACCGTGGATACTTGAGTCAATATATGGTTTCTAATACAGAGAAAATGGTTGCTGAGTTAG
ATAATCCTTATATTCTGATTACGGATAAAAAAATCTCAAATATTCAAGAAATTTTACCGCTTCTTGAACAAATTTTGAAA
ACAAATCGTCCACTTTTAATTGTTGCTGATGATGTTGATGGAGAAGCATTGCCAACTCTTGTTCTTAATAAGATTAAAGG
GGTCTTCAACGTAGTCGCTGTAAAAGCACCGGGATTTGGTGACCGCCGTAAAGCTCAATTGGAAGATTTAGCTATCTTGA
CAGGTGGTACAGTAATTACTGAAGAACTTGGCCTTGATCTTAAAGATGCTACACTAGAAGCTTTAGGACAAGCTGCTAAA
GCAACTGTTGATAAAGACCATACAACAATTGTTGAAGGTGCTGGTTCTGTTGGTGCCATTTCTGATCGTGTGGCTATCAT
CAAAGCACAAATCGAAAAAATAACTTCTGATTTTGACCGTGAAAAATTGCAAGAGCGCTTAGCGAAATTAGCTGGCGGAG
TTGCGGTAGTTAAAGTAGGAGCCGCAACAGAAACAGAACTTAAAGCAATGAAACTTTTGATTGAAGACGCACTTAATGCA
ACACGTGCTGCTGTTGAAGAAGGTATCGTTTCTGGTGGTGGTACAGCTCTTGTTAATGCCATCGCAGCTTTGGATAAACT
TTCAGAAGAAGGCGACATTCAAACAGGAATTAACATCGTTCGCCGTGCCCTTGAAGAACCAGTTCGTCAAATCGCGGCCA
ATGCAGGATATGAAGGTTCAGTTATCATTGATAAACTTCGTTCAGAAAAAGTTGGTACAGGATTTAATGCAGCGACAGGT
CAATGGGTAAATATGATTGAAGAAGGAATCGTTGACCCGGCAAAAGTGACTCGTTCAGCTTTGCAAAATGCAGCTTCTGT
TGCTGGATTAATCTTGACTACTGAAGCAGTTGTGGCTAATAAACCAGAACCAGCTGCTCCAGCTATGCCTCCAATGGACC
CTAGCATGGGAATGGGTGGTATGATGTAA

Upstream 100 bases:

>100_bases
CAATTGTAGAGTAAAAATATAAAAGCAATCAATTTTTGATTGTCTTTTGTCTATCTTAAAATCTATTAATTAAAAATATA
TTCTTAAAAAAGGAGCTAAA

Downstream 100 bases:

>100_bases
TAAAAAAAAGAACCCGAGTGGGTTCTTTTTTATTTTTTAATGATTAATGTTAGATATCATAAAGGGGACTTGCATGTTCA
TGGCTGGTATCAAGAATTTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSKEIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYI
SDAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAK
ATVDKDHTTIVEGAGSVGAISDRVAIIKAQIEKITSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNA
TRAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEKVGTGFNAATG
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM

Sequences:

>Translated_542_residues
MSKEIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYI
SDAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAK
ATVDKDHTTIVEGAGSVGAISDRVAIIKAQIEKITSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNA
TRAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEKVGTGFNAATG
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM
>Mature_541_residues
SKEIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTN
DIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYIS
DAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILKT
NRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAKA
TVDKDHTTIVEGAGSVGAISDRVAIIKAQIEKITSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNAT
RAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEKVGTGFNAATGQ
WVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=50.2857142857143, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=50.2857142857143, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI302058290, Length=512, Percent_Identity=21.6796875, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI58331173, Length=544, Percent_Identity=20.9558823529412, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38455427, Length=562, Percent_Identity=23.4875444839858, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4502643, Length=547, Percent_Identity=21.5722120658135, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=59.5419847328244, Blast_Score=624, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=48.1132075471698, Blast_Score=485, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=47.3684210526316, Blast_Score=175, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17564182, Length=554, Percent_Identity=23.6462093862816, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25144674, Length=173, Percent_Identity=30.635838150289, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=50, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322350, Length=554, Percent_Identity=23.1046931407942, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322524, Length=113, Percent_Identity=34.5132743362832, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320058, Length=167, Percent_Identity=28.7425149700599, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322446, Length=547, Percent_Identity=22.6691042047532, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=48.7619047619048, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=48.7619047619048, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=46.5648854961832, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=46.5648854961832, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=46.5648854961832, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=42.6386233269598, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=34.7663551401869, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=34.7663551401869, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24645179, Length=518, Percent_Identity=23.7451737451737, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24652903, Length=174, Percent_Identity=30.4597701149425, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17647245, Length=174, Percent_Identity=30.4597701149425, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583944, Length=181, Percent_Identity=26.5193370165746, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57197; Mature: 57066

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYISDAMERVGSDGVITIEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHEEEEECCEEEH
EELGLDLKDATLEALGQAAKATVDKDHTTIVEGAGSVGAISDRVAIIKAQIEKITSDFDR
HHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNATRAAVEEGIVSGGGTALVNA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEKVGTGFNAATG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCH
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MM
CC
>Mature Secondary Structure 
SKEIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYISDAMERVGSDGVITIEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILK
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
TNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHEEEEECCEEEH
EELGLDLKDATLEALGQAAKATVDKDHTTIVEGAGSVGAISDRVAIIKAQIEKITSDFDR
HHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNATRAAVEEGIVSGGGTALVNA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEKVGTGFNAATG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCH
QWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8486277; 11337471 [H]