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The map label for this gene is tmk [H]

Identifier: 125623282

GI number: 125623282

Start: 409112

End: 409747

Strand: Direct

Name: tmk [H]

Synonym: llmg_0415

Alternate gene names: 125623282

Gene position: 409112-409747 (Clockwise)

Preceding gene: 125623278

Following gene: 125623283

Centisome position: 16.17

GC content: 39.31

Gene sequence:

>636_bases
ATGAATGGAATTTTAATTTCCCTAGAGGGACCTGATGGAGCAGGAAAAACAACAGTTTTGCAAGAAATTTTGCCTGAAAT
CCAAAAAATGAAGCGTGAAGTTGTCCCAACTCGAGAACCAGGTGGGGTTCGAGTGGCTGAAGAAATTCGGCAAATTATTC
TCGATCCAAAGAATACAGAGATTGATTCAAAAACAGAATTGATGCTTTTTGCGGCGGCGCGCCGTTTACATATGCAAGAA
AAAATGTTGCCAGCTTTACGAGCAGGTAAGGTTGTCATTGTTGACCGATTTATTGACTCCTCTGTCGCTTATCAGGGTTA
TGGCCGTGATTTGGGTGTTGAGGTGGTGGATTGGCTTAATTATTTTGCAACAGATGGTTTAAAACCTGATTTGACTTTAT
ATTTTGATATTGATACAGATGTTGCACTTGAACGGATTATGAAAAATCGAGCGGATGAGGTCAATCGCCTAGACTTAGAA
AGAGCTGAGATGCATCGAAAAGTTCGAGAGGGTTATTTGGAAATTGTTGCAAAAGAACCTGGGCGTTTTGTAAAAATAGA
TGCGAGTCAATCTTTGGAAAAGGTTGTAGCTGATACACTTGAAGTTCTGAAAAAAAGATTTGTCAGTGAATTTTAA

Upstream 100 bases:

>100_bases
TCAGTTATATTATACAATTTTTAGTAAAATTACGCAAAAAGTGACCCCTATATTTTTAGAAAAAAGATAAAAAGTTTGAT
TTTTTGATATAATAGAGGCT

Downstream 100 bases:

>100_bases
AGACAACTTAATCTGTCAGCAAATTTAATAAAGTGATAAATACTGACAAAAATAAAAAATACGTAGATGTCAAAAAAATT
TTTTTATTTTGTTATTTAAA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MNGILISLEGPDGAGKTTVLQEILPEIQKMKREVVPTREPGGVRVAEEIRQIILDPKNTEIDSKTELMLFAAARRLHMQE
KMLPALRAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLNYFATDGLKPDLTLYFDIDTDVALERIMKNRADEVNRLDLE
RAEMHRKVREGYLEIVAKEPGRFVKIDASQSLEKVVADTLEVLKKRFVSEF

Sequences:

>Translated_211_residues
MNGILISLEGPDGAGKTTVLQEILPEIQKMKREVVPTREPGGVRVAEEIRQIILDPKNTEIDSKTELMLFAAARRLHMQE
KMLPALRAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLNYFATDGLKPDLTLYFDIDTDVALERIMKNRADEVNRLDLE
RAEMHRKVREGYLEIVAKEPGRFVKIDASQSLEKVVADTLEVLKKRFVSEF
>Mature_211_residues
MNGILISLEGPDGAGKTTVLQEILPEIQKMKREVVPTREPGGVRVAEEIRQIILDPKNTEIDSKTELMLFAAARRLHMQE
KMLPALRAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLNYFATDGLKPDLTLYFDIDTDVALERIMKNRADEVNRLDLE
RAEMHRKVREGYLEIVAKEPGRFVKIDASQSLEKVVADTLEVLKKRFVSEF

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=215, Percent_Identity=35.3488372093023, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23973; Mature: 23973

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGILISLEGPDGAGKTTVLQEILPEIQKMKREVVPTREPGGVRVAEEIRQIILDPKNTE
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCC
IDSKTELMLFAAARRLHMQEKMLPALRAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCHHHHCCCCCCCCHHHHHHHH
YFATDGLKPDLTLYFDIDTDVALERIMKNRADEVNRLDLERAEMHRKVREGYLEIVAKEP
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRFVKIDASQSLEKVVADTLEVLKKRFVSEF
CCEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGILISLEGPDGAGKTTVLQEILPEIQKMKREVVPTREPGGVRVAEEIRQIILDPKNTE
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCC
IDSKTELMLFAAARRLHMQEKMLPALRAGKVVIVDRFIDSSVAYQGYGRDLGVEVVDWLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCHHHHCCCCCCCCHHHHHHHH
YFATDGLKPDLTLYFDIDTDVALERIMKNRADEVNRLDLERAEMHRKVREGYLEIVAKEP
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRFVKIDASQSLEKVVADTLEVLKKRFVSEF
CCEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]