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The map label for this gene is pdhA [H]

Identifier: 125622953

GI number: 125622953

Start: 69478

End: 70602

Strand: Reverse

Name: pdhA [H]

Synonym: llmg_0074

Alternate gene names: 125622953

Gene position: 70602-69478 (Counterclockwise)

Preceding gene: 125622954

Following gene: 125622952

Centisome position: 2.79

GC content: 41.78

Gene sequence:

>1125_bases
ATGTCAAATTCAGAACAAATCTTAGATTTCAAAACGCAGCTATCACTGCAAGACACCGCATTTCCAATGCTACAAATTCT
TAATGAAGAAGGAAAAATTGTTGACGAAGAAGGTCTTAAACGTGCAGGGCTTTCTGATGAAAAACTCGTTGAACTCTTTA
AAAGCATGCTTTTTGCACGACAAGTTGACATTCGCTCAATGAAATTAGCTAAACAAGGACGTATGGGATTCTTTGGACCT
CACGCTGGTCAAGAAGCTTCTCAAATGGCCTCAGCTTTTGCTTTCACTGATGAAGACTGGCTTTTCCCAGGTTATCGTGA
TTTGCCACAAATCTACGCTAAAGGTTGGCCAATTTGGAAAGGGCTTCTTTGGTCTCGTGGACATCAACTTGGTAATGAAT
ATACCACTGATGATGGTAAACCTGTAAACTCATGGTTTCCACAAATTATTATCGGTGCTCAATACGTTGAGGCCGCTGGT
GTAGCACTCGGACTTAAAAAACGTAAAAAAGATGCTGTAGCCTTCGTTTACACTGGAGATGGTGGTTCTTCACAAGGGGA
CACTTATGAAGGAATCAACTTTGCTGGTGCCTATAAAGCCCCACTTGTTGCCTTTATCCAAAACAATGGTTATGCCATTT
CGACTCCTCGTAGCCTACAAAGTGCCGCTCCTCATTTGGCCGCTAAAGGTTGGGCTGCCGGCGCTCCGTCTATCGTTGTT
GATGGAATGGACGCAATTGCCATGTATCTTGCTTCTAAAGAAGCTCGTGCTTGGGCAGTAGCTGGAAATGGTCCGGTTGT
TATTGAAGCTATTACAAACCGTCTTGAACCCCATTCAACGGCTGGTGATGACCCACTTCGCTATCGTACTAAAGAAGATA
TTGAAGCTTGGTGGAAAAAAGAACCACTCGTCCGTATGCGTAATTTCTTAACTGAAAAAGGACTTTGGGATACAGATAAA
GAAGAAGCTTATGTTGCTGAGCTTGATGCACGTATTGATGCTGATATCAAGAAAGCAAATAATGTTGAAAAACAAAAAAT
TTCAAGCTTCATTAAAAATACACTTGAAGTGCCAAGCCAAGCAATGGCAGAACAAATTGCAAAATTTGAAAGCGAGGGCA
AATAA

Upstream 100 bases:

>100_bases
CGAGTCGACTAACTTATTTCACAAGCATAACCTTAGGAAATTTCTCCAAAAAATGATAAATTTCTAATTATAGACACATA
AAATAGAAAGGGAATCTATT

Downstream 100 bases:

>100_bases
GAATGGCAGTAAAAACTTATATTGCAGCAATTACAGAAGCGCTTGATTTGGCGCTTGAAAAAGACAAAGATGCACTCATT
TTTGGTGAAGACGTCGGACA

Product: pyruvate dehydrogenase E1 component alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSNSEQILDFKTQLSLQDTAFPMLQILNEEGKIVDEEGLKRAGLSDEKLVELFKSMLFARQVDIRSMKLAKQGRMGFFGP
HAGQEASQMASAFAFTDEDWLFPGYRDLPQIYAKGWPIWKGLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAG
VALGLKKRKKDAVAFVYTGDGGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKKEPLVRMRNFLTEKGLWDTDK
EEAYVAELDARIDADIKKANNVEKQKISSFIKNTLEVPSQAMAEQIAKFESEGK

Sequences:

>Translated_374_residues
MSNSEQILDFKTQLSLQDTAFPMLQILNEEGKIVDEEGLKRAGLSDEKLVELFKSMLFARQVDIRSMKLAKQGRMGFFGP
HAGQEASQMASAFAFTDEDWLFPGYRDLPQIYAKGWPIWKGLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAG
VALGLKKRKKDAVAFVYTGDGGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKKEPLVRMRNFLTEKGLWDTDK
EEAYVAELDARIDADIKKANNVEKQKISSFIKNTLEVPSQAMAEQIAKFESEGK
>Mature_373_residues
SNSEQILDFKTQLSLQDTAFPMLQILNEEGKIVDEEGLKRAGLSDEKLVELFKSMLFARQVDIRSMKLAKQGRMGFFGPH
AGQEASQMASAFAFTDEDWLFPGYRDLPQIYAKGWPIWKGLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAGV
ALGLKKRKKDAVAFVYTGDGGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVVD
GMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKKEPLVRMRNFLTEKGLWDTDKE
EAYVAELDARIDADIKKANNVEKQKISSFIKNTLEVPSQAMAEQIAKFESEGK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=357, Percent_Identity=30.812324929972, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI258645172, Length=357, Percent_Identity=30.5322128851541, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI4885543, Length=295, Percent_Identity=27.7966101694915, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI4505685, Length=301, Percent_Identity=27.2425249169435, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI291084742, Length=301, Percent_Identity=27.2425249169435, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI291084744, Length=191, Percent_Identity=31.413612565445, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI291084757, Length=299, Percent_Identity=24.4147157190635, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI86563357, Length=350, Percent_Identity=30.8571428571429, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI86563355, Length=350, Percent_Identity=30.8571428571429, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32564172, Length=303, Percent_Identity=27.7227722772277, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17536047, Length=303, Percent_Identity=27.7227722772277, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=303, Percent_Identity=29.042904290429, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355903, Length=344, Percent_Identity=30.8139534883721, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639744, Length=324, Percent_Identity=27.7777777777778, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28571106, Length=324, Percent_Identity=27.7777777777778, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24639740, Length=324, Percent_Identity=27.7777777777778, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24639746, Length=281, Percent_Identity=29.5373665480427, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24639748, Length=345, Percent_Identity=25.5072463768116, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41352; Mature: 41221

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSEQILDFKTQLSLQDTAFPMLQILNEEGKIVDEEGLKRAGLSDEKLVELFKSMLFAR
CCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECHHHHHHCCCCHHHHHHHHHHHHHHH
QVDIRSMKLAKQGRMGFFGPHAGQEASQMASAFAFTDEDWLFPGYRDLPQIYAKGWPIWK
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHH
GLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAGVALGLKKRKKDAVAFVYTGD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
CCCCCCCCCCCCCCCCCHHCCEEEEEECCCEEEECCHHHHHHCCHHHHCCCCCCCCCEEE
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKK
CCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCC
EPLVRMRNFLTEKGLWDTDKEEAYVAELDARIDADIKKANNVEKQKISSFIKNTLEVPSQ
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHCCHH
AMAEQIAKFESEGK
HHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSEQILDFKTQLSLQDTAFPMLQILNEEGKIVDEEGLKRAGLSDEKLVELFKSMLFAR
CCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECHHHHHHCCCCHHHHHHHHHHHHHHH
QVDIRSMKLAKQGRMGFFGPHAGQEASQMASAFAFTDEDWLFPGYRDLPQIYAKGWPIWK
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHH
GLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAGVALGLKKRKKDAVAFVYTGD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
CCCCCCCCCCCCCCCCCHHCCEEEEEECCCEEEECCHHHHHHCCHHHHCCCCCCCCCEEE
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKK
CCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCC
EPLVRMRNFLTEKGLWDTDKEEAYVAELDARIDADIKKANNVEKQKISSFIKNTLEVPSQ
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHCCHH
AMAEQIAKFESEGK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA