Click here to switch to the map view.

The map label for this gene is lplL [H]

Identifier: 125622954

GI number: 125622954

Start: 70691

End: 71692

Strand: Reverse

Name: lplL [H]

Synonym: llmg_0075

Alternate gene names: 125622954

Gene position: 71692-70691 (Counterclockwise)

Preceding gene: 125622955

Following gene: 125622953

Centisome position: 2.83

GC content: 40.82

Gene sequence:

>1002_bases
ATGCAATTTATTAACTATCTAGGTCAAGACGCTTACACCAATATCGCGATGGACAGCTGGCTCCTTTACAACTTAAAGCC
AACTGAGCCTGTTTTTGCTCTCTGGCAAAACAAACGTGCGGTTATTGTTGGGCGCAACCAAAATACTTTTGCCGAAGTAA
ATCAGGACTACATTGACAGTCATGACGTCCAAGTTGTTCGTCGGGTATCTGGCGGTGGCGCTGTTTATCATGATGAGGGT
AACATTTGTTTCACCTTTTTTGTTCCAGTTGAAAATTCTGGTTCTGTAAACTTTAAAAAGTTTGTTCAGCCTATGTATGA
AGCACTTCATGCTGTAGGAATTAAAGCAGAAATCACCGGACGTAATGACCTTGAAGTTGAAGGCAAAAAGATTTCAGGGA
ATGCGCAACGCTATGCAGGAGGATATCTCATGCACCACGGAACGCTACTTTGGGATACCGATGTTGAAGCTATGATTCGC
TCGCTTAATGTATCCGATGAAAAATTTGTCAGTAAAGCGGCCAAATCAGTCCGTGCTCGAGTAGGAAATATTAAAGATTT
TGCGCCTGATGAATTAAGCTTAGATAGCTTTATTGAAGCTTTGAAATACTACCTCACTGACGAAGGAAAAGACGGCGAAT
TAGTCTTAACTGATGAGCAACTTGATTCCATCAAAAAAATACGTGATGAACAATTTGCTACATGGGACTGGAATTATGGT
GAATCACCTAAGTTCTCCTTCCAAAACCACGCTAAATTTACTGGCGGAGCCATTGATATTCAAGTCAATGTTGAAAATGG
TAAAATTACCGAAATTAATTTCCAAGGAGATTTCTTGGGGATTCGCGACTGGCGGGATATTAAAGACCAATTTATTGGCG
TTGAATTTGAACCCGCAGCCGTCCTACAAGTCCTTGAAGCAAATAAGGACGGGCAATATTTCGGAACAATTCAAAATACC
GAACTTTCTGAAATGTTCAAAGCCGACTATCGAGTCGACTAA

Upstream 100 bases:

>100_bases
TTACATTTTGTTTCACAAAGGGTATAATTAAATCGTGCGTGTTATTTTGTCAAACTTATTTGATAAAATAAGCACAAGGA
TTTGGAAGGGATGCATAAAT

Downstream 100 bases:

>100_bases
CTTATTTCACAAGCATAACCTTAGGAAATTTCTCCAAAAAATGATAAATTTCTAATTATAGACACATAAAATAGAAAGGG
AATCTATTATGTCAAATTCA

Product: lipoate-protein ligase

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MQFINYLGQDAYTNIAMDSWLLYNLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDSHDVQVVRRVSGGGAVYHDEG
NICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITGRNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIR
SLNVSDEKFVSKAAKSVRARVGNIKDFAPDELSLDSFIEALKYYLTDEGKDGELVLTDEQLDSIKKIRDEQFATWDWNYG
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGIRDWRDIKDQFIGVEFEPAAVLQVLEANKDGQYFGTIQNT
ELSEMFKADYRVD

Sequences:

>Translated_333_residues
MQFINYLGQDAYTNIAMDSWLLYNLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDSHDVQVVRRVSGGGAVYHDEG
NICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITGRNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIR
SLNVSDEKFVSKAAKSVRARVGNIKDFAPDELSLDSFIEALKYYLTDEGKDGELVLTDEQLDSIKKIRDEQFATWDWNYG
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGIRDWRDIKDQFIGVEFEPAAVLQVLEANKDGQYFGTIQNT
ELSEMFKADYRVD
>Mature_333_residues
MQFINYLGQDAYTNIAMDSWLLYNLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDSHDVQVVRRVSGGGAVYHDEG
NICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITGRNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIR
SLNVSDEKFVSKAAKSVRARVGNIKDFAPDELSLDSFIEALKYYLTDEGKDGELVLTDEQLDSIKKIRDEQFATWDWNYG
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGIRDWRDIKDQFIGVEFEPAAVLQVLEANKDGQYFGTIQNT
ELSEMFKADYRVD

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=311, Percent_Identity=31.5112540192926, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI21729884, Length=311, Percent_Identity=31.5112540192926, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI21729882, Length=311, Percent_Identity=31.5112540192926, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI21729880, Length=311, Percent_Identity=31.5112540192926, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI21729878, Length=311, Percent_Identity=31.5112540192926, Blast_Score=128, Evalue=6e-30,
Organism=Escherichia coli, GI1790846, Length=310, Percent_Identity=32.5806451612903, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71981909, Length=239, Percent_Identity=33.8912133891213, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322415, Length=295, Percent_Identity=26.7796610169492, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573464, Length=288, Percent_Identity=31.9444444444444, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 37784; Mature: 37784

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFINYLGQDAYTNIAMDSWLLYNLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDS
CCHHHHHCCCHHHHEEECCEEEEECCCCCCHHHEECCCEEEEEECCCCCHHHCCHHHCCC
HDVQVVRRVSGGGAVYHDEGNICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITG
CCCEEEEEECCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECC
RNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIRSLNVSDEKFVSKAAKSVRAR
CCCCEEECEEECCCCHHHCCCEEEECCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHH
VGNIKDFAPDELSLDSFIEALKYYLTDEGKDGELVLTDEQLDSIKKIRDEQFATWDWNYG
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCEEECCCCC
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGIRDWRDIKDQFIGVEFEPAA
CCCCCCCCCCCEECCCEEEEEEEECCCEEEEEEECCCEEECCCHHHHHHHHCCCEECHHH
VLQVLEANKDGQYFGTIQNTELSEMFKADYRVD
HHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCC
>Mature Secondary Structure
MQFINYLGQDAYTNIAMDSWLLYNLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDS
CCHHHHHCCCHHHHEEECCEEEEECCCCCCHHHEECCCEEEEEECCCCCHHHCCHHHCCC
HDVQVVRRVSGGGAVYHDEGNICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITG
CCCEEEEEECCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECC
RNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIRSLNVSDEKFVSKAAKSVRAR
CCCCEEECEEECCCCHHHCCCEEEECCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHH
VGNIKDFAPDELSLDSFIEALKYYLTDEGKDGELVLTDEQLDSIKKIRDEQFATWDWNYG
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCEEECCCCC
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGIRDWRDIKDQFIGVEFEPAA
CCCCCCCCCCCEECCCEEEEEEEECCCEEEEEEECCCEEECCCHHHHHHHHCCCEECHHH
VLQVLEANKDGQYFGTIQNTELSEMFKADYRVD
HHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]