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The map label for this gene is pdhB [H]

Identifier: 125622952

GI number: 125622952

Start: 68495

End: 69475

Strand: Reverse

Name: pdhB [H]

Synonym: llmg_0073

Alternate gene names: 125622952

Gene position: 69475-68495 (Counterclockwise)

Preceding gene: 125622953

Following gene: 125622951

Centisome position: 2.75

GC content: 41.9

Gene sequence:

>981_bases
ATGGCAGTAAAAACTTATATTGCAGCAATTACAGAAGCGCTTGATTTGGCGCTTGAAAAAGACAAAGATGCACTCATTTT
TGGTGAAGACGTCGGACAAAATGGTGGGGTTTTCCGTGCCACTGACGGACTTCAAGCAAAATATGGTGAAGACCGCGTTT
TCAATACTCCACTCGCAGAATCAGGAATTGGTGGAATGGCAATTGGTCTTGCAACACAAGGTTTCCACCCAATTATGGAA
ATCCAATTCGGGACCTTTATCTTTGAAGTTTTCGACTCAATTGCTGGACAAATGAGCCGGACACGTTATCGTTTTAATAA
CACTCGTTCAAATAATATTGTCGTGCGTACGCCTTATGGTATCGGAACTAAAACACCTGAAATGCATGCTGATTCAATCG
AAGGATTGTTTTCACAACTCCCAGGGGTACGTGTGGTTATGCCTTCAAATCCAGCGGATGCTAAAGGTTTGCTACTCGCA
TCAATTGAAAATAATGACCCTGTTATTTTCCTTGAAAACCTCCACCTTTACCGTTCATTAAAAGGTGAAGTTCCTGAGGG
TTACTACACAACACCGCTTGACCAAGCAGCCGTGGCTAAAGAGGGTTCTGATGTTTCAATCATTGCTTATGGTGGAACTG
TTCCTCTTGCTCTCAAAGCTGCTGAACAACTTGAAAAAGATGGAATCAAAGCTGAAGTTATTGACCTTAGAACTGTTGCT
CCTCTTGACATCGCATCAATCGGTAAAACAGTTGAAAAAACTGGACGTGTTGTTGTTGTTCAAGAAGCTCAACGTACCGC
TGGTATTGCGGCAAATGTAATGGCTGAAATTTCAGAACGTTTTGTCTTGAATCTCAAAGCACCTATTGGACGCGTAACTG
GTCCAGACTCAATTTTCCCATTTGCACAAGCGGAAAATGATTGGGCAGTTAAAGCTGAAGATATCGTGAATAAAGTTAAA
GAGGTGGTTGATTATGACTGA

Upstream 100 bases:

>100_bases
AAAAACAAAAAATTTCAAGCTTCATTAAAAATACACTTGAAGTGCCAAGCCAAGCAATGGCAGAACAAATTGCAAAATTT
GAAAGCGAGGGCAAATAAGA

Downstream 100 bases:

>100_bases
GATTTTTAAAATGCCTGATATTGGCGAAGGAATGCACGAAGGGGACATTGCCAACTGGTTAGTTAAAGTTGGAGATGTTG
TTAAAGAAGATGATCCAATT

Product: pyruvate dehydrogenase E1 component beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGLATQGFHPIME
IQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYGIGTKTPEMHADSIEGLFSQLPGVRVVMPSNPADAKGLLLA
SIENNDPVIFLENLHLYRSLKGEVPEGYYTTPLDQAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVIDLRTVA
PLDIASIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVTGPDSIFPFAQAENDWAVKAEDIVNKVK
EVVDYD

Sequences:

>Translated_326_residues
MAVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGLATQGFHPIME
IQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYGIGTKTPEMHADSIEGLFSQLPGVRVVMPSNPADAKGLLLA
SIENNDPVIFLENLHLYRSLKGEVPEGYYTTPLDQAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVIDLRTVA
PLDIASIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVTGPDSIFPFAQAENDWAVKAEDIVNKVK
EVVDYD
>Mature_325_residues
AVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGLATQGFHPIMEI
QFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYGIGTKTPEMHADSIEGLFSQLPGVRVVMPSNPADAKGLLLAS
IENNDPVIFLENLHLYRSLKGEVPEGYYTTPLDQAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVIDLRTVAP
LDIASIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVTGPDSIFPFAQAENDWAVKAEDIVNKVKE
VVDYD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=294, Percent_Identity=46.5986394557823, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI34101272, Length=294, Percent_Identity=46.5986394557823, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI156564403, Length=321, Percent_Identity=32.0872274143302, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI291084858, Length=321, Percent_Identity=30.8411214953271, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17506935, Length=322, Percent_Identity=40.9937888198758, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17538422, Length=321, Percent_Identity=34.8909657320872, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6319698, Length=321, Percent_Identity=35.5140186915888, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI160714828, Length=317, Percent_Identity=42.2712933753943, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI160714832, Length=294, Percent_Identity=43.5374149659864, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI21358145, Length=320, Percent_Identity=33.4375, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24650940, Length=320, Percent_Identity=33.4375, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI160714826, Length=60, Percent_Identity=61.6666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650943, Length=84, Percent_Identity=38.0952380952381, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24650945, Length=84, Percent_Identity=38.0952380952381, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45551847, Length=290, Percent_Identity=27.2413793103448, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550715, Length=290, Percent_Identity=27.2413793103448, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24645119, Length=290, Percent_Identity=27.2413793103448, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35165; Mature: 35034

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEDRVFNTPLAE
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCEECCCCCC
SGIGGMAIGLATQGFHPIMEIQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYG
CCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCC
IGTKTPEMHADSIEGLFSQLPGVRVVMPSNPADAKGLLLASIENNDPVIFLENLHLYRSL
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCHHHHHH
KGEVPEGYYTTPLDQAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVIDLRTVA
CCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECC
PLDIASIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVTGPDSIFP
CCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
FAQAENDWAVKAEDIVNKVKEVVDYD
CCCCCCCCEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEDRVFNTPLAE
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCEECCCCCC
SGIGGMAIGLATQGFHPIMEIQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYG
CCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCC
IGTKTPEMHADSIEGLFSQLPGVRVVMPSNPADAKGLLLASIENNDPVIFLENLHLYRSL
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCHHHHHH
KGEVPEGYYTTPLDQAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVIDLRTVA
CCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECC
PLDIASIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVTGPDSIFP
CCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
FAQAENDWAVKAEDIVNKVKEVVDYD
CCCCCCCCEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]