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The map label for this gene is flpA [H]

Identifier: 124486448

GI number: 124486448

Start: 1662572

End: 1663174

Strand: Reverse

Name: flpA [H]

Synonym: Mlab_1636

Alternate gene names: 124486448

Gene position: 1663174-1662572 (Counterclockwise)

Preceding gene: 124486449

Following gene: 124486446

Centisome position: 92.14

GC content: 55.39

Gene sequence:

>603_bases
ATGATTCAGATCAACGGCACGCTCGTCTCCGAAGGCCCCGGAGGAGTGTACAATGAGCGGATGCTTGGAAACTTCCGTGT
CTGGGATCCGTACCGGAGCAAACTTGCCGCTCTCTGGTATCTGGACAAAACGACCTCCCTTGGGAAGGACGATGTCGTCC
TCTATCTCGGAGCCGCAAACGGAACGACCGTCTCCCACGTGGCGGACTATGTGGAATCAGTTTACGCCGTAGAGTTTGCT
CCCCGCCCGATGGAGGACCTTCTGGCGGTTGCCAAAAAACGTAAAAACATCATCCCGATCTACGCCGATGCGACCCGCCC
GGTTCGATACGCCGCTCTTCTCGAACCGGCAGATCTGCTGTATCAGGATGTTGCCCAGCCGGATCAGGCAGAGATCGCAG
TGAAGCATCTGCCGTTTGTAAAATCAGGAGGCCGTCTCATTCTGATGCTGAAAACCCGGAGCGTGGATATCAGAAAGTCT
GCCGATGAGGTGTTTGCCGATACGTGTGCGGAGCTGACGGCCGGCGGATATCTGATGGAAAAAAGCGTGTGGCTGGATCC
GTATCACAAAGAGCACGCGGCGATCGTCTGCAGAAAAATCTAA

Upstream 100 bases:

>100_bases
TCGCGATCGCCGCCCGTCTGGATCTGTATCGGGGCGAACTTGATCCCGAATTCGTCGATCAGGCGAATGCCAAAATCGAC
AGCATTTTCGGAGGGGAAGC

Downstream 100 bases:

>100_bases
GAGGGGCAGTTTCCCTCTAAAAAATTACTTATCTTACTCTTTTCTCGGTGCCGGGCACTCTCCGTAATCATGTCTCTTTA
TTCTTCTAAGGGAGAGCCAG

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MIQINGTLVSEGPGGVYNERMLGNFRVWDPYRSKLAALWYLDKTTSLGKDDVVLYLGAANGTTVSHVADYVESVYAVEFA
PRPMEDLLAVAKKRKNIIPIYADATRPVRYAALLEPADLLYQDVAQPDQAEIAVKHLPFVKSGGRLILMLKTRSVDIRKS
ADEVFADTCAELTAGGYLMEKSVWLDPYHKEHAAIVCRKI

Sequences:

>Translated_200_residues
MIQINGTLVSEGPGGVYNERMLGNFRVWDPYRSKLAALWYLDKTTSLGKDDVVLYLGAANGTTVSHVADYVESVYAVEFA
PRPMEDLLAVAKKRKNIIPIYADATRPVRYAALLEPADLLYQDVAQPDQAEIAVKHLPFVKSGGRLILMLKTRSVDIRKS
ADEVFADTCAELTAGGYLMEKSVWLDPYHKEHAAIVCRKI
>Mature_200_residues
MIQINGTLVSEGPGGVYNERMLGNFRVWDPYRSKLAALWYLDKTTSLGKDDVVLYLGAANGTTVSHVADYVESVYAVEFA
PRPMEDLLAVAKKRKNIIPIYADATRPVRYAALLEPADLLYQDVAQPDQAEIAVKHLPFVKSGGRLILMLKTRSVDIRKS
ADEVFADTCAELTAGGYLMEKSVWLDPYHKEHAAIVCRKI

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=178, Percent_Identity=42.1348314606742, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17563672, Length=178, Percent_Identity=42.1348314606742, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320190, Length=182, Percent_Identity=43.4065934065934, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17647425, Length=178, Percent_Identity=43.2584269662921, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646406, Length=187, Percent_Identity=33.1550802139037, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 22246; Mature: 22246

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQINGTLVSEGPGGVYNERMLGNFRVWDPYRSKLAALWYLDKTTSLGKDDVVLYLGAAN
CEEECCEEEECCCCCCCCCCEECCEEEECHHHHHEEEEEEEECCCCCCCCCEEEEEECCC
GTTVSHVADYVESVYAVEFAPRPMEDLLAVAKKRKNIIPIYADATRPVRYAALLEPADLL
CCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEHHHCCHHHHH
YQDVAQPDQAEIAVKHLPFVKSGGRLILMLKTRSVDIRKSADEVFADTCAELTAGGYLME
HHHHCCCCHHHEEEHHCCEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEE
KSVWLDPYHKEHAAIVCRKI
CCEECCCCCCCCCEEEEECC
>Mature Secondary Structure
MIQINGTLVSEGPGGVYNERMLGNFRVWDPYRSKLAALWYLDKTTSLGKDDVVLYLGAAN
CEEECCEEEECCCCCCCCCCEECCEEEECHHHHHEEEEEEEECCCCCCCCCEEEEEECCC
GTTVSHVADYVESVYAVEFAPRPMEDLLAVAKKRKNIIPIYADATRPVRYAALLEPADLL
CCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEHHHCCHHHHH
YQDVAQPDQAEIAVKHLPFVKSGGRLILMLKTRSVDIRKSADEVFADTCAELTAGGYLME
HHHHCCCCHHHEEEHHCCEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEE
KSVWLDPYHKEHAAIVCRKI
CCEECCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA