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The map label for this gene is trpD

Identifier: 124486214

GI number: 124486214

Start: 1426286

End: 1427308

Strand: Reverse

Name: trpD

Synonym: Mlab_1397

Alternate gene names: 124486214

Gene position: 1427308-1426286 (Counterclockwise)

Preceding gene: 124486215

Following gene: 124486213

Centisome position: 79.08

GC content: 50.15

Gene sequence:

>1023_bases
ATGATCGCAGAATGCATTAAAAAAGTAGCATCACATTCTGATCTGAGCGTTTACGAGGCAAAAGGGGCGATGCAGGATAT
CATGTCAGGAAACGCTACCGATGGTCAGATCGGCGCATTCCTTACAGCCCTTGTAATGAAAGGGGAGACAAGTTCCGAGA
TCGCCGCTTTTGCATCCGTGATGCGGGAGAACGCCGTCCAAATAACTCCGAAAAGAAACGGTATGCTTGTCGATACATGC
GGCACCGGAGGCGATGGAAAAAACACCTTCAACATCAGTACGGCAGCGGCTTTTACTGCGGCCGGTGCTGGAGTGACTGT
CGTCAAGCATGGAAACCGGGGAGCGACCAGCAAATGCGGATCCGCTGATGTTCTGGAAGCCCTCGGGATAAAAATCGATA
TTTCGCCGGAAAGGGTCTGTGAAATCATCGATGAAAACGGCATAGGGTTTATGTTTGCCCAAAGCCATCATCCTGCTATG
AAGTATGCGGGCAAGGTGAGAAAGGAGATCGGTATCCGCAGCTTCTTCAATCTTATCGGTCCCCTCTCGAATCCTGCAGG
AGCCGATGCACAGCTGCTTGGGGTCTATGACTCTCCCCTCACGGAAAAGATCGCCGAAGTTCTCAATATTTTGGGTACGA
AAAGAGCAATGGTTGTCCATGGTGATGGATATGATGAGATAACAACGACTGGTATTACTCAGGTTTCCGAGGTGAACGAC
GGGCAGGTCAGGAGTTATTCCTTGGATCCGTCATCCTTCGGGTTCCAAAAAGCCGATGCCGCCTCCCTCTTCGGTGGAGA
TTCTCAGTACAATGCACACATAATCAGATCGGTTCTTTCGGGAGATGAAGGTCCGAGACGGGATATCGTCATCCTCAATG
CCGCAGCTGCAATCTATCTTGGAGAGAGGGCAGGGAGTATCGCGGATGGGATCAAATATGCGGAAAAATCCATCGATTCG
GGCCTTGCGCTCGAGAAACTGGAGAATCTGATTCTCCTTTCTGGAGGCAAAAATGATTCTTGA

Upstream 100 bases:

>100_bases
AAAAGTATCCGGTGTTCGGGCTCCAGTTCCATCCAGAAAGCCTCCTCACAGAATCGGGTGACAAAATCATGAAAAATTTC
CTGAATACAGGAGTGATCCG

Downstream 100 bases:

>100_bases
TGACATTTGTGCCCGCTCAAGAGAAAGGGCAGCACTGCTCGACCCCTCTATAAGGAAAACCTCCGAAGAGACAACCTATG
TTCCGCAAAGCCTCATCAAA

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MIAECIKKVASHSDLSVYEAKGAMQDIMSGNATDGQIGAFLTALVMKGETSSEIAAFASVMRENAVQITPKRNGMLVDTC
GTGGDGKNTFNISTAAAFTAAGAGVTVVKHGNRGATSKCGSADVLEALGIKIDISPERVCEIIDENGIGFMFAQSHHPAM
KYAGKVRKEIGIRSFFNLIGPLSNPAGADAQLLGVYDSPLTEKIAEVLNILGTKRAMVVHGDGYDEITTTGITQVSEVND
GQVRSYSLDPSSFGFQKADAASLFGGDSQYNAHIIRSVLSGDEGPRRDIVILNAAAAIYLGERAGSIADGIKYAEKSIDS
GLALEKLENLILLSGGKNDS

Sequences:

>Translated_340_residues
MIAECIKKVASHSDLSVYEAKGAMQDIMSGNATDGQIGAFLTALVMKGETSSEIAAFASVMRENAVQITPKRNGMLVDTC
GTGGDGKNTFNISTAAAFTAAGAGVTVVKHGNRGATSKCGSADVLEALGIKIDISPERVCEIIDENGIGFMFAQSHHPAM
KYAGKVRKEIGIRSFFNLIGPLSNPAGADAQLLGVYDSPLTEKIAEVLNILGTKRAMVVHGDGYDEITTTGITQVSEVND
GQVRSYSLDPSSFGFQKADAASLFGGDSQYNAHIIRSVLSGDEGPRRDIVILNAAAAIYLGERAGSIADGIKYAEKSIDS
GLALEKLENLILLSGGKNDS
>Mature_340_residues
MIAECIKKVASHSDLSVYEAKGAMQDIMSGNATDGQIGAFLTALVMKGETSSEIAAFASVMRENAVQITPKRNGMLVDTC
GTGGDGKNTFNISTAAAFTAAGAGVTVVKHGNRGATSKCGSADVLEALGIKIDISPERVCEIIDENGIGFMFAQSHHPAM
KYAGKVRKEIGIRSFFNLIGPLSNPAGADAQLLGVYDSPLTEKIAEVLNILGTKRAMVVHGDGYDEITTTGITQVSEVND
GQVRSYSLDPSSFGFQKADAASLFGGDSQYNAHIIRSVLSGDEGPRRDIVILNAAAAIYLGERAGSIADGIKYAEKSIDS
GLALEKLENLILLSGGKNDS

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=280, Percent_Identity=38.2142857142857, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1787019, Length=304, Percent_Identity=22.3684210526316, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320561, Length=323, Percent_Identity=31.5789473684211, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_METLZ (A2STA7)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030830.1
- ProteinModelPortal:   A2STA7
- SMR:   A2STA7
- STRING:   A2STA7
- GeneID:   4796162
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1397
- eggNOG:   arNOG05391
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- PhylomeDB:   A2STA7
- ProtClustDB:   PRK00188
- BioCyc:   MLAB410358:MLAB_1397-MONOMER
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 35572; Mature: 35572

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAECIKKVASHSDLSVYEAKGAMQDIMSGNATDGQIGAFLTALVMKGETSSEIAAFASV
CHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
MRENAVQITPKRNGMLVDTCGTGGDGKNTFNISTAAAFTAAGAGVTVVKHGNRGATSKCG
HHCCCEEEEECCCCEEEEECCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCC
SADVLEALGIKIDISPERVCEIIDENGIGFMFAQSHHPAMKYAGKVRKEIGIRSFFNLIG
CHHHHHHCCCEEECCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
PLSNPAGADAQLLGVYDSPLTEKIAEVLNILGTKRAMVVHGDGYDEITTTGITQVSEVND
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCHHCCCC
GQVRSYSLDPSSFGFQKADAASLFGGDSQYNAHIIRSVLSGDEGPRRDIVILNAAAAIYL
CCEEEEECCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCEEEEE
GERAGSIADGIKYAEKSIDSGLALEKLENLILLSGGKNDS
CCCCCCHHHHHHHHHHHHCCCHHHHHHCCEEEEECCCCCC
>Mature Secondary Structure
MIAECIKKVASHSDLSVYEAKGAMQDIMSGNATDGQIGAFLTALVMKGETSSEIAAFASV
CHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
MRENAVQITPKRNGMLVDTCGTGGDGKNTFNISTAAAFTAAGAGVTVVKHGNRGATSKCG
HHCCCEEEEECCCCEEEEECCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCC
SADVLEALGIKIDISPERVCEIIDENGIGFMFAQSHHPAMKYAGKVRKEIGIRSFFNLIG
CHHHHHHCCCEEECCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
PLSNPAGADAQLLGVYDSPLTEKIAEVLNILGTKRAMVVHGDGYDEITTTGITQVSEVND
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCHHCCCC
GQVRSYSLDPSSFGFQKADAASLFGGDSQYNAHIIRSVLSGDEGPRRDIVILNAAAAIYL
CCEEEEECCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCEEEEE
GERAGSIADGIKYAEKSIDSGLALEKLENLILLSGGKNDS
CCCCCCHHHHHHHHHHHHCCCHHHHHHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA