Click here to switch to the map view.

The map label for this gene is trpC [H]

Identifier: 124486213

GI number: 124486213

Start: 1425529

End: 1426296

Strand: Reverse

Name: trpC [H]

Synonym: Mlab_1396

Alternate gene names: 124486213

Gene position: 1426296-1425529 (Counterclockwise)

Preceding gene: 124486214

Following gene: 124486212

Centisome position: 79.02

GC content: 49.61

Gene sequence:

>768_bases
ATGATTCTTGATGACATTTGTGCCCGCTCAAGAGAAAGGGCAGCACTGCTCGACCCCTCTATAAGGAAAACCTCCGAAGA
GACAACCTATGTTCCGCAAAGCCTCATCAAATCCGTGAAAAACTGCCAGGGCCGGAAAAATGCGGTTATCGCTGAGATCA
AATACAAAACTCCCTCGGACAAAACCCTTGACTCGAGGAGGGATCCGGCGAACCTCTCCCGTCTGTATGAATCGGGCGGG
GCATGTGCTGTTTCCGTTCTGACTGAACCTTTCTACTTCTCCGGAAGTGCGGAAAATCTCACCAAAGCAAAATCCGGGAC
CCGGCTTCCGATCCTTAGAAAGGATTTCATCGTCGATGAAAAACAGATCTACGAAACCTACGTCATGCAGGCCGATTCAG
TGCTTCTGATAGCCGATGTTCTGCAGGACCGGCTTGAAGAGTTCATCCTTCTTTGCCAGTCTCTGCATCTCGAACCTCTG
GTCGAGGTCAGGAACCGGGAAGATGCGGAAAATGCCGTAAAATCCGGGGCACTGCTGACCGGCATCAATAACCGGAATCT
CCATGACATGTCGGTCGATACGAAAACAACAGAAGAACTCTCATGCCTTCTTCGGGATGCGGGTCTTACTGTGATCTCCG
AGAGCGGCATCAAAACACCTGAGGATGTCCTTGGTCTGAAAAATTTATGTGACGGTTTTCTCATTGGAACCTCTCTCATG
AAGTCTGCAGATCCGCAAAAAACTTTGGAGGCATTCGTATGCGTGTAA

Upstream 100 bases:

>100_bases
GGGAGTATCGCGGATGGGATCAAATATGCGGAAAAATCCATCGATTCGGGCCTTGCGCTCGAGAAACTGGAGAATCTGAT
TCTCCTTTCTGGAGGCAAAA

Downstream 100 bases:

>100_bases
AAATCTGCGGGATCACCACGGTAAGGGATGCGTTAATCGCGGAAGAAGAGGGTGCCGACGCGATTGGAATCGTCGTCTGT
TCGGATTCCAAACGTTCGGT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MILDDICARSRERAALLDPSIRKTSEETTYVPQSLIKSVKNCQGRKNAVIAEIKYKTPSDKTLDSRRDPANLSRLYESGG
ACAVSVLTEPFYFSGSAENLTKAKSGTRLPILRKDFIVDEKQIYETYVMQADSVLLIADVLQDRLEEFILLCQSLHLEPL
VEVRNREDAENAVKSGALLTGINNRNLHDMSVDTKTTEELSCLLRDAGLTVISESGIKTPEDVLGLKNLCDGFLIGTSLM
KSADPQKTLEAFVCV

Sequences:

>Translated_255_residues
MILDDICARSRERAALLDPSIRKTSEETTYVPQSLIKSVKNCQGRKNAVIAEIKYKTPSDKTLDSRRDPANLSRLYESGG
ACAVSVLTEPFYFSGSAENLTKAKSGTRLPILRKDFIVDEKQIYETYVMQADSVLLIADVLQDRLEEFILLCQSLHLEPL
VEVRNREDAENAVKSGALLTGINNRNLHDMSVDTKTTEELSCLLRDAGLTVISESGIKTPEDVLGLKNLCDGFLIGTSLM
KSADPQKTLEAFVCV
>Mature_255_residues
MILDDICARSRERAALLDPSIRKTSEETTYVPQSLIKSVKNCQGRKNAVIAEIKYKTPSDKTLDSRRDPANLSRLYESGG
ACAVSVLTEPFYFSGSAENLTKAKSGTRLPILRKDFIVDEKQIYETYVMQADSVLLIADVLQDRLEEFILLCQSLHLEPL
VEVRNREDAENAVKSGALLTGINNRNLHDMSVDTKTTEELSCLLRDAGLTVISESGIKTPEDVLGLKNLCDGFLIGTSLM
KSADPQKTLEAFVCV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=203, Percent_Identity=41.871921182266, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322638, Length=217, Percent_Identity=36.8663594470046, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28205; Mature: 28205

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDDICARSRERAALLDPSIRKTSEETTYVPQSLIKSVKNCQGRKNAVIAEIKYKTPSD
CCCHHHHHCCCCCHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
KTLDSRRDPANLSRLYESGGACAVSVLTEPFYFSGSAENLTKAKSGTRLPILRKDFIVDE
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHCCCCCCCCHHHHHHCCH
KQIYETYVMQADSVLLIADVLQDRLEEFILLCQSLHLEPLVEVRNREDAENAVKSGALLT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCEEE
GINNRNLHDMSVDTKTTEELSCLLRDAGLTVISESGIKTPEDVLGLKNLCDGFLIGTSLM
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
KSADPQKTLEAFVCV
HCCCHHHHHHHHHCC
>Mature Secondary Structure
MILDDICARSRERAALLDPSIRKTSEETTYVPQSLIKSVKNCQGRKNAVIAEIKYKTPSD
CCCHHHHHCCCCCHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
KTLDSRRDPANLSRLYESGGACAVSVLTEPFYFSGSAENLTKAKSGTRLPILRKDFIVDE
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHCCCCCCCCHHHHHHCCH
KQIYETYVMQADSVLLIADVLQDRLEEFILLCQSLHLEPLVEVRNREDAENAVKSGALLT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCEEE
GINNRNLHDMSVDTKTTEELSCLLRDAGLTVISESGIKTPEDVLGLKNLCDGFLIGTSLM
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
KSADPQKTLEAFVCV
HCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA