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The map label for this gene is trpGD [H]

Identifier: 124486215

GI number: 124486215

Start: 1427305

End: 1427883

Strand: Reverse

Name: trpGD [H]

Synonym: Mlab_1398

Alternate gene names: 124486215

Gene position: 1427883-1427305 (Counterclockwise)

Preceding gene: 124486216

Following gene: 124486214

Centisome position: 79.11

GC content: 51.12

Gene sequence:

>579_bases
ATGAACGTTCTGGTAATCGACTGTTACGACAGTTTCACCTACAATCTCTGTCAGCAGATAGGATATCTCGGGGGAAAACC
GATCGTGGTTAAAAATGACCGACCAAACGATCTCCCGGATGCGTCGGAATTTGACCGGATCGTTCTTTCTCCGGGTCCAG
GAAAACCGGAGGACTCCGCCCTCTGTCTGGATATCCTGGAAACTTATTCAGAAGAGATCCCCACTCTCGGGATTTGCCTT
GGGCACCAGGCGATATGCCACTTCTTTGGAGGAAAAGTCATTCGGACCGGAAAACCGGTACACGGCATGACCTCCGAGAT
TCTGCATGACGGGACCGGCCTCTTTGCCGGGGTCGAAAATCCATTCAAAGCGACACGGTATCACTCGCTTGCCGCTGAAG
AATCGTCCCTTCCCTCCTGTCTGTCGGTTTCGGCACGAAGCAAAGAAGACGGGATGATCATGGCAGTTTCCCACAAAAAG
TATCCGGTGTTCGGGCTCCAGTTCCATCCAGAAAGCCTCCTCACAGAATCGGGTGACAAAATCATGAAAAATTTCCTGAA
TACAGGAGTGATCCGATGA

Upstream 100 bases:

>100_bases
CCGGCATCGTTGCGGATTCCAATCCTGCATCTGAATTCATCGAGTCGGAAAACAAGGCCGCAAGCATGAAGGCAGCAATT
GAATCGGCGGGTGAAATCGC

Downstream 100 bases:

>100_bases
TCGCAGAATGCATTAAAAAAGTAGCATCACATTCTGATCTGAGCGTTTACGAGGCAAAAGGGGCGATGCAGGATATCATG
TCAGGAAACGCTACCGATGG

Product: anthranilate synthase, component II

Products: NA

Alternate protein names: Glutamine amidotransferase; Anthranilate phosphoribosyltransferase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MNVLVIDCYDSFTYNLCQQIGYLGGKPIVVKNDRPNDLPDASEFDRIVLSPGPGKPEDSALCLDILETYSEEIPTLGICL
GHQAICHFFGGKVIRTGKPVHGMTSEILHDGTGLFAGVENPFKATRYHSLAAEESSLPSCLSVSARSKEDGMIMAVSHKK
YPVFGLQFHPESLLTESGDKIMKNFLNTGVIR

Sequences:

>Translated_192_residues
MNVLVIDCYDSFTYNLCQQIGYLGGKPIVVKNDRPNDLPDASEFDRIVLSPGPGKPEDSALCLDILETYSEEIPTLGICL
GHQAICHFFGGKVIRTGKPVHGMTSEILHDGTGLFAGVENPFKATRYHSLAAEESSLPSCLSVSARSKEDGMIMAVSHKK
YPVFGLQFHPESLLTESGDKIMKNFLNTGVIR
>Mature_192_residues
MNVLVIDCYDSFTYNLCQQIGYLGGKPIVVKNDRPNDLPDASEFDRIVLSPGPGKPEDSALCLDILETYSEEIPTLGICL
GHQAICHFFGGKVIRTGKPVHGMTSEILHDGTGLFAGVENPFKATRYHSLAAEESSLPSCLSVSARSKEDGMIMAVSHKK
YPVFGLQFHPESLLTESGDKIMKNFLNTGVIR

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=173, Percent_Identity=28.9017341040462, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789760, Length=187, Percent_Identity=47.0588235294118, Blast_Score=181, Evalue=2e-47,
Organism=Escherichia coli, GI1787517, Length=193, Percent_Identity=38.860103626943, Blast_Score=140, Evalue=4e-35,
Organism=Escherichia coli, GI1786215, Length=131, Percent_Identity=31.2977099236641, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193204318, Length=174, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322638, Length=190, Percent_Identity=47.3684210526316, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324361, Length=215, Percent_Identity=35.3488372093023, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005940
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase; PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3 [H]

EC number: =4.1.3.27; =2.4.2.18 [H]

Molecular weight: Translated: 20976; Mature: 20976

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLVIDCYDSFTYNLCQQIGYLGGKPIVVKNDRPNDLPDASEFDRIVLSPGPGKPEDSA
CCEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHCCEEEECCCCCCCCCCH
LCLDILETYSEEIPTLGICLGHQAICHFFGGKVIRTGKPVHGMTSEILHDGTGLFAGVEN
HHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHCCCCEEECCCC
PFKATRYHSLAAEESSLPSCLSVSARSKEDGMIMAVSHKKYPVFGLQFHPESLLTESGDK
CHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCEEEEEECCHHHHHCCHHH
IMKNFLNTGVIR
HHHHHHHHCCCC
>Mature Secondary Structure
MNVLVIDCYDSFTYNLCQQIGYLGGKPIVVKNDRPNDLPDASEFDRIVLSPGPGKPEDSA
CCEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHCCEEEECCCCCCCCCCH
LCLDILETYSEEIPTLGICLGHQAICHFFGGKVIRTGKPVHGMTSEILHDGTGLFAGVEN
HHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHCCCCEEECCCC
PFKATRYHSLAAEESSLPSCLSVSARSKEDGMIMAVSHKKYPVFGLQFHPESLLTESGDK
CHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCEEEEEECCHHHHHCCHHH
IMKNFLNTGVIR
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685830; 10360571; 7556082 [H]