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The map label for this gene is 124485834

Identifier: 124485834

GI number: 124485834

Start: 1022687

End: 1024597

Strand: Reverse

Name: 124485834

Synonym: Mlab_1014

Alternate gene names: NA

Gene position: 1024597-1022687 (Counterclockwise)

Preceding gene: 124485835

Following gene: 124485833

Centisome position: 56.77

GC content: 52.8

Gene sequence:

>1911_bases
ATGCAGGTTGAAGACAGACTCAAAGAACTCAAAGTAACTATTAATAAAAAAGTTCCTCGTGGAGTTACCGTAACGGATGT
TGAATTTGAAGGCCCGGAGATGGTCATCTATACTGATGATCCGAAAAGGTTTGCCGAGGATCATGACCTGATCAAAACGC
TTGCCCGCGATTTACGCAAACGTATCGTTGTCCGCCCCAATATTCTTGGAGATACCGAAGAGGCCTATGATATGATCAAG
GCAGTTGTGCCTGAATCAGCAGGGATCACGGATATTTTCTTCGATACTGATACGGGAGAGGTCCTGATCGAGGCTGAAAA
GCCGGGCGTCGTTATCGGGAAGAACGGCTCTACGCTTCGCGACATCACCATGAAGACAGGATGGACGCCGAAGGCTGCGA
GAACCCCGCCGATTCCCTCCGTGACGATCAAACAGGTTCGTCAGTATCTTCGTGAATCCCGTGACGAGAGAAAGGAGTTT
CTCCGTAAATGCGGGAAGCGGATCCACCGGGATTCCATCTATACCGGCCGCGATCACGATCAGTGGCTTCGTCTGACCAC
GCTCGGGTGCTGCCGTCAGGTCGGTCGTGCGGCGTTTCTTTTGAGCACGCCGGAAAGCAAAGTCCTGATCGACTGCGGGG
AATCCCCCGGAGCAACCGGCGCTGCCTCTTCGCCGTATCTGAACGTCCCTGAAATCTATCCGTTCACGAATCTTGACGCC
GTCGTTTTGACCCATGCTCATCTTGATCACTCTGCATTTATCCCGCTGTTATACAGATACGGATACGACGGGCCTGTCTA
TACAACCCCCGCCACCCGCGATCTTGCGACGATGCTTCAGCTGGATTATCTGGATGTGAACAACAAAGAGGACCGTGCTC
CGCCGTACTCTTCGAACGAGATCCGTGAATTCGTGAAGCATACCATAGCCCTCGGCTACGGCGACGTAACCGACATCGCC
CCCGACATGAAACTCACCCTGCACAACGCCGGCCATATTCTCGGCTCCGCCATCGCCCACTTCAATGTAGGAAACGGCGT
GTACAACGTTGCCTTTACCGGCGATCTGTTCTACGGGAAGAGCCGCCTCTTTAACCCGGCAGTCTCCCAGTTCCCGCGGC
TGGAGTCTCTCGTTATCGAGAGTACCTACGGAGGTTCGGATGACTTTTCTCCTTCAAGAGTCGAGGCGGAAGAGCGGCTG
TATGAGGTCATCAACGAAACGCTCGGCCGCGGCGGAAAAGTTCTGATCCCGGCATTTGCCGTCGGACGATCCCAGGAACT
GATGCTCGCCATCGAAGAGGGTATGAGAAACAACCGGATCCCAAAATGCAAGGTCTATCTTGACGGAATGATCAAGGAAG
CAACCGCGATGCACACGGCTTACCCAGAGTATCTCAACACCGACCTTCGCAATCTTATCTTCCGTGACAACTATAATCCG
TTCCTTGCCGACTGTTTCGAACAGGTCGATTCCTACGACAAACGTCAGCAGGTCATCTTCTCGGAAGATCCCTGTGTCAT
CATCTCCACGAGCGGTATGATGAACGGCGGTCCGGTGATCGAATATTTAAGCAACCTTGCCGAGTCTCCGAAGAATATGA
TCGTCTTTGTTGGATATCAGGCTGAAGGAACCTACGGACGCCGTATCCAGAAAGGCTGGCGTGAAGTGCCGATCGGCAAA
CGCGGCACGATCGTTATCAATATGGAGATCCAGACCGTGGAAGGATTTTCAGGTCACGCCGACCGAAAACAGCTGATGAA
TTACGTCCAGTACGTTCAGCCGAAACCCGAGCGTGTCTTTACGATCCATGGCGAAGAGTCCAAGACAATCGACTTTGCCA
GTTCCATCTATAAGAAATTCCATATCCAAACCGTGGCCCCCCAGAATCTCGAGACCTACCGGATGGTCTGA

Upstream 100 bases:

>100_bases
TGATAATAACCCAGGAGAAGTTCGAATATCTTCCTGAGGATAAAATAGCCGGGTATCTGCCCCCGGCAAAATAATCTCAC
TTTTTTTGGAAACGAATTTT

Downstream 100 bases:

>100_bases
TCATCTATACCTGAATCAACCATTTTTTTCTTTTTCCCAAGCATCTTTGCATGTCCCGAATCTCCCGATTACTGTTATAA
TCTTTTGATTCTGCCTCGCA

Product: ADP-ribosylation/crystallin J1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MQVEDRLKELKVTINKKVPRGVTVTDVEFEGPEMVIYTDDPKRFAEDHDLIKTLARDLRKRIVVRPNILGDTEEAYDMIK
AVVPESAGITDIFFDTDTGEVLIEAEKPGVVIGKNGSTLRDITMKTGWTPKAARTPPIPSVTIKQVRQYLRESRDERKEF
LRKCGKRIHRDSIYTGRDHDQWLRLTTLGCCRQVGRAAFLLSTPESKVLIDCGESPGATGAASSPYLNVPEIYPFTNLDA
VVLTHAHLDHSAFIPLLYRYGYDGPVYTTPATRDLATMLQLDYLDVNNKEDRAPPYSSNEIREFVKHTIALGYGDVTDIA
PDMKLTLHNAGHILGSAIAHFNVGNGVYNVAFTGDLFYGKSRLFNPAVSQFPRLESLVIESTYGGSDDFSPSRVEAEERL
YEVINETLGRGGKVLIPAFAVGRSQELMLAIEEGMRNNRIPKCKVYLDGMIKEATAMHTAYPEYLNTDLRNLIFRDNYNP
FLADCFEQVDSYDKRQQVIFSEDPCVIISTSGMMNGGPVIEYLSNLAESPKNMIVFVGYQAEGTYGRRIQKGWREVPIGK
RGTIVINMEIQTVEGFSGHADRKQLMNYVQYVQPKPERVFTIHGEESKTIDFASSIYKKFHIQTVAPQNLETYRMV

Sequences:

>Translated_636_residues
MQVEDRLKELKVTINKKVPRGVTVTDVEFEGPEMVIYTDDPKRFAEDHDLIKTLARDLRKRIVVRPNILGDTEEAYDMIK
AVVPESAGITDIFFDTDTGEVLIEAEKPGVVIGKNGSTLRDITMKTGWTPKAARTPPIPSVTIKQVRQYLRESRDERKEF
LRKCGKRIHRDSIYTGRDHDQWLRLTTLGCCRQVGRAAFLLSTPESKVLIDCGESPGATGAASSPYLNVPEIYPFTNLDA
VVLTHAHLDHSAFIPLLYRYGYDGPVYTTPATRDLATMLQLDYLDVNNKEDRAPPYSSNEIREFVKHTIALGYGDVTDIA
PDMKLTLHNAGHILGSAIAHFNVGNGVYNVAFTGDLFYGKSRLFNPAVSQFPRLESLVIESTYGGSDDFSPSRVEAEERL
YEVINETLGRGGKVLIPAFAVGRSQELMLAIEEGMRNNRIPKCKVYLDGMIKEATAMHTAYPEYLNTDLRNLIFRDNYNP
FLADCFEQVDSYDKRQQVIFSEDPCVIISTSGMMNGGPVIEYLSNLAESPKNMIVFVGYQAEGTYGRRIQKGWREVPIGK
RGTIVINMEIQTVEGFSGHADRKQLMNYVQYVQPKPERVFTIHGEESKTIDFASSIYKKFHIQTVAPQNLETYRMV
>Mature_636_residues
MQVEDRLKELKVTINKKVPRGVTVTDVEFEGPEMVIYTDDPKRFAEDHDLIKTLARDLRKRIVVRPNILGDTEEAYDMIK
AVVPESAGITDIFFDTDTGEVLIEAEKPGVVIGKNGSTLRDITMKTGWTPKAARTPPIPSVTIKQVRQYLRESRDERKEF
LRKCGKRIHRDSIYTGRDHDQWLRLTTLGCCRQVGRAAFLLSTPESKVLIDCGESPGATGAASSPYLNVPEIYPFTNLDA
VVLTHAHLDHSAFIPLLYRYGYDGPVYTTPATRDLATMLQLDYLDVNNKEDRAPPYSSNEIREFVKHTIALGYGDVTDIA
PDMKLTLHNAGHILGSAIAHFNVGNGVYNVAFTGDLFYGKSRLFNPAVSQFPRLESLVIESTYGGSDDFSPSRVEAEERL
YEVINETLGRGGKVLIPAFAVGRSQELMLAIEEGMRNNRIPKCKVYLDGMIKEATAMHTAYPEYLNTDLRNLIFRDNYNP
FLADCFEQVDSYDKRQQVIFSEDPCVIISTSGMMNGGPVIEYLSNLAESPKNMIVFVGYQAEGTYGRRIQKGWREVPIGK
RGTIVINMEIQTVEGFSGHADRKQLMNYVQYVQPKPERVFTIHGEESKTIDFASSIYKKFHIQTVAPQNLETYRMV

Specific function: Unknown

COG id: COG1782

COG function: function code R; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI33300633, Length=457, Percent_Identity=29.1028446389497, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI7706427, Length=468, Percent_Identity=27.3504273504274, Blast_Score=182, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32566029, Length=474, Percent_Identity=27.8481012658228, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32564696, Length=462, Percent_Identity=26.8398268398268, Blast_Score=168, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6323307, Length=459, Percent_Identity=26.5795206971678, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21358523, Length=455, Percent_Identity=28.1318681318681, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24648013, Length=443, Percent_Identity=25.7336343115124, Blast_Score=175, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR004087
- InterPro:   IPR019975
- InterPro:   IPR004044
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF07650 KH_2; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 71661; Mature: 71661

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50084 KH_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVEDRLKELKVTINKKVPRGVTVTDVEFEGPEMVIYTDDPKRFAEDHDLIKTLARDLRK
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
RIVVRPNILGDTEEAYDMIKAVVPESAGITDIFFDTDTGEVLIEAEKPGVVIGKNGSTLR
HEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCEEE
DITMKTGWTPKAARTPPIPSVTIKQVRQYLRESRDERKEFLRKCGKRIHRDSIYTGRDHD
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
QWLRLTTLGCCRQVGRAAFLLSTPESKVLIDCGESPGATGAASSPYLNVPEIYPFTNLDA
HHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VVLTHAHLDHSAFIPLLYRYGYDGPVYTTPATRDLATMLQLDYLDVNNKEDRAPPYSSNE
EEEEEECCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHEEECCCCCCCCCCCCCCHH
IREFVKHTIALGYGDVTDIAPDMKLTLHNAGHILGSAIAHFNVGNGVYNVAFTGDLFYGK
HHHHHHHHHHCCCCCHHHCCCCCEEEEECCCHHHHHHHHHEECCCCEEEEEEECEEEECC
SRLFNPAVSQFPRLESLVIESTYGGSDDFSPSRVEAEERLYEVINETLGRGGKVLIPAFA
HHCCCHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VGRSQELMLAIEEGMRNNRIPKCKVYLDGMIKEATAMHTAYPEYLNTDLRNLIFRDNYNP
CCCCCHHHHEEHHCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHCCHHHHHHCCCCCCH
FLADCFEQVDSYDKRQQVIFSEDPCVIISTSGMMNGGPVIEYLSNLAESPKNMIVFVGYQ
HHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEE
AEGTYGRRIQKGWREVPIGKRGTIVINMEIQTVEGFSGHADRKQLMNYVQYVQPKPERVF
CCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEE
TIHGEESKTIDFASSIYKKFHIQTVAPQNLETYRMV
EEECCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure
MQVEDRLKELKVTINKKVPRGVTVTDVEFEGPEMVIYTDDPKRFAEDHDLIKTLARDLRK
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
RIVVRPNILGDTEEAYDMIKAVVPESAGITDIFFDTDTGEVLIEAEKPGVVIGKNGSTLR
HEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCEEE
DITMKTGWTPKAARTPPIPSVTIKQVRQYLRESRDERKEFLRKCGKRIHRDSIYTGRDHD
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
QWLRLTTLGCCRQVGRAAFLLSTPESKVLIDCGESPGATGAASSPYLNVPEIYPFTNLDA
HHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VVLTHAHLDHSAFIPLLYRYGYDGPVYTTPATRDLATMLQLDYLDVNNKEDRAPPYSSNE
EEEEEECCCCHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHEEECCCCCCCCCCCCCCHH
IREFVKHTIALGYGDVTDIAPDMKLTLHNAGHILGSAIAHFNVGNGVYNVAFTGDLFYGK
HHHHHHHHHHCCCCCHHHCCCCCEEEEECCCHHHHHHHHHEECCCCEEEEEEECEEEECC
SRLFNPAVSQFPRLESLVIESTYGGSDDFSPSRVEAEERLYEVINETLGRGGKVLIPAFA
HHCCCHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VGRSQELMLAIEEGMRNNRIPKCKVYLDGMIKEATAMHTAYPEYLNTDLRNLIFRDNYNP
CCCCCHHHHEEHHCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHCCHHHHHHCCCCCCH
FLADCFEQVDSYDKRQQVIFSEDPCVIISTSGMMNGGPVIEYLSNLAESPKNMIVFVGYQ
HHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEE
AEGTYGRRIQKGWREVPIGKRGTIVINMEIQTVEGFSGHADRKQLMNYVQYVQPKPERVF
CCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEE
TIHGEESKTIDFASSIYKKFHIQTVAPQNLETYRMV
EEECCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]