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The map label for this gene is psmB

Identifier: 124485835

GI number: 124485835

Start: 1024624

End: 1025262

Strand: Reverse

Name: psmB

Synonym: Mlab_1015

Alternate gene names: 124485835

Gene position: 1025262-1024624 (Counterclockwise)

Preceding gene: 124485836

Following gene: 124485834

Centisome position: 56.8

GC content: 51.49

Gene sequence:

>639_bases
ATGTCACAAGAACACCAGGACGTTAAAACGGGAACCACCACAGTGGGTATTGTATTCGATGGCGGCGTCATCCTTGCTAC
CGAGAGGCGGGCAACGATGGGTAACTTGATCGCCAGCAAGAAAGCAAAGAAAGTACATGCCATCACTGATAAGATCGGTA
TGACAATCGCCGGTGGGGTTGGGGATGCCCAGCAGCTTGTCAGAATCATCAATGTCGAATGCAACCTCTACGAGATCCGC
AGAGGTCAGAAGATCAGTGTCGGGGCGGCAGCAACGATCCTTTCCAATTATCTGAACCAGAATCGCTTTTCACCATACTA
CGTTCAGCTTCTTGTCGGTGGTGTCGATACCAGCGGTCCTTCCGTATACTCCGTAGATGCGGCCGGCGGAGCAACGCTTG
AAGAGAACTTTGTCTCGACGGGATCTGGATCGCTGACAGCCTACGGTGTCTTAGAGGATCGGTTCAAACCCAATATGACC
GAGGAGGAAGCAATCGAACTAGCCGTACGTGCACTTCGCGCAGCAATGCTTCGTGACTCGGCTTCCGGAGAGGGATACAA
TGTGGTGATAATAACCCAGGAGAAGTTCGAATATCTTCCTGAGGATAAAATAGCCGGGTATCTGCCCCCGGCAAAATAA

Upstream 100 bases:

>100_bases
TTTATCACATTTAGCGTACACTTAACTATTAGCGCTTTTAGCTGTTTCAATGAAAACAGTGTTTTATGAATTTGCAGCGT
ACCTTAATTTGAGGTTTCTC

Downstream 100 bases:

>100_bases
TCTCACTTTTTTTGGAAACGAATTTTATGCAGGTTGAAGACAGACTCAAAGAACTCAAAGTAACTATTAATAAAAAAGTT
CCTCGTGGAGTTACCGTAAC

Product: hypothetical protein

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PsmB

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSQEHQDVKTGTTTVGIVFDGGVILATERRATMGNLIASKKAKKVHAITDKIGMTIAGGVGDAQQLVRIINVECNLYEIR
RGQKISVGAAATILSNYLNQNRFSPYYVQLLVGGVDTSGPSVYSVDAAGGATLEENFVSTGSGSLTAYGVLEDRFKPNMT
EEEAIELAVRALRAAMLRDSASGEGYNVVIITQEKFEYLPEDKIAGYLPPAK

Sequences:

>Translated_212_residues
MSQEHQDVKTGTTTVGIVFDGGVILATERRATMGNLIASKKAKKVHAITDKIGMTIAGGVGDAQQLVRIINVECNLYEIR
RGQKISVGAAATILSNYLNQNRFSPYYVQLLVGGVDTSGPSVYSVDAAGGATLEENFVSTGSGSLTAYGVLEDRFKPNMT
EEEAIELAVRALRAAMLRDSASGEGYNVVIITQEKFEYLPEDKIAGYLPPAK
>Mature_211_residues
SQEHQDVKTGTTTVGIVFDGGVILATERRATMGNLIASKKAKKVHAITDKIGMTIAGGVGDAQQLVRIINVECNLYEIRR
GQKISVGAAATILSNYLNQNRFSPYYVQLLVGGVDTSGPSVYSVDAAGGATLEENFVSTGSGSLTAYGVLEDRFKPNMTE
EEAIELAVRALRAAMLRDSASGEGYNVVIITQEKFEYLPEDKIAGYLPPAK

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI73747875, Length=190, Percent_Identity=37.3684210526316, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4758970, Length=190, Percent_Identity=37.3684210526316, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4506201, Length=195, Percent_Identity=35.8974358974359, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI4506203, Length=192, Percent_Identity=35.4166666666667, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI4506191, Length=186, Percent_Identity=38.7096774193548, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI22538465, Length=175, Percent_Identity=29.1428571428571, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI23110925, Length=215, Percent_Identity=30.6976744186047, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI153791216, Length=189, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI195539356, Length=150, Percent_Identity=32.6666666666667, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI4506193, Length=198, Percent_Identity=31.8181818181818, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4506205, Length=187, Percent_Identity=30.4812834224599, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI222144262, Length=110, Percent_Identity=38.1818181818182, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI23110942, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508499, Length=209, Percent_Identity=38.755980861244, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17508495, Length=183, Percent_Identity=40.4371584699454, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17535357, Length=187, Percent_Identity=32.620320855615, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17541700, Length=202, Percent_Identity=27.2277227722772, Blast_Score=90, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17554384, Length=194, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508493, Length=177, Percent_Identity=27.1186440677966, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325360, Length=192, Percent_Identity=36.4583333333333, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324731, Length=204, Percent_Identity=34.8039215686275, Blast_Score=108, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322459, Length=199, Percent_Identity=27.1356783919598, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320941, Length=175, Percent_Identity=26.8571428571429, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320849, Length=172, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319430, Length=203, Percent_Identity=25.615763546798, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355573, Length=173, Percent_Identity=40.4624277456647, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24652553, Length=173, Percent_Identity=40.4624277456647, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24639979, Length=199, Percent_Identity=32.1608040201005, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130281, Length=177, Percent_Identity=34.4632768361582, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24584895, Length=183, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664391, Length=192, Percent_Identity=31.7708333333333, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28573221, Length=212, Percent_Identity=31.1320754716981, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653999, Length=190, Percent_Identity=30.5263157894737, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355629, Length=175, Percent_Identity=27.4285714285714, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24654391, Length=203, Percent_Identity=26.6009852216749, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24654389, Length=203, Percent_Identity=26.6009852216749, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129563, Length=187, Percent_Identity=24.0641711229947, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281360341, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586406, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586400, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586402, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB_METLZ (A2SS78)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030451.1
- ProteinModelPortal:   A2SS78
- SMR:   A2SS78
- MEROPS:   T01.002
- GeneID:   4794522
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1015
- eggNOG:   arNOG10234
- HOGENOM:   HBG499923
- OMA:   MAYGVLE
- PhylomeDB:   A2SS78
- ProtClustDB:   CLSK949526
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 22694; Mature: 22563

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEHQDVKTGTTTVGIVFDGGVILATERRATMGNLIASKKAKKVHAITDKIGMTIAGGV
CCCCCCCCCCCCEEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
GDAQQLVRIINVECNLYEIRRGQKISVGAAATILSNYLNQNRFSPYYVQLLVGGVDTSGP
CCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCC
SVYSVDAAGGATLEENFVSTGSGSLTAYGVLEDRFKPNMTEEEAIELAVRALRAAMLRDS
CEEEEECCCCCCHHHHHCCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
ASGEGYNVVIITQEKFEYLPEDKIAGYLPPAK
CCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQEHQDVKTGTTTVGIVFDGGVILATERRATMGNLIASKKAKKVHAITDKIGMTIAGGV
CCCCCCCCCCCEEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
GDAQQLVRIINVECNLYEIRRGQKISVGAAATILSNYLNQNRFSPYYVQLLVGGVDTSGP
CCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCC
SVYSVDAAGGATLEENFVSTGSGSLTAYGVLEDRFKPNMTEEEAIELAVRALRAAMLRDS
CEEEEECCCCCCHHHHHCCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
ASGEGYNVVIITQEKFEYLPEDKIAGYLPPAK
CCCCCEEEEEEEHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA