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The map label for this gene is fdhA [H]

Identifier: 124485288

GI number: 124485288

Start: 440503

End: 442572

Strand: Reverse

Name: fdhA [H]

Synonym: Mlab_0463

Alternate gene names: 124485288

Gene position: 442572-440503 (Counterclockwise)

Preceding gene: 124485294

Following gene: 124485287

Centisome position: 24.52

GC content: 53.82

Gene sequence:

>2070_bases
ATGACTGATTTGAAGTATGTAACAACAACCTGTCCGTACTGCGGAACCGGTTGCTCATTCAACCTCGTTGTCCGTGACGG
AAAAACCGTTGGGGTCACTCCCTTCACCCGTTCACCTGTCAACGAAGGTAAACTGTGTCCAAAAGGCATGTACGCATTTG
AGTTCGTCAACAGCCCCGACAGACTTACCACCCCTCTTATCAAGAAGGACGGTAAATTCGTTCCGGCAAGCTGGGATGAA
GCAACTGACTACATCGCACAGAAGATGAAGACATTCAAGCCCTCCGAGATTGCATGTCTTGCATCCGCCAGAACCTCTAA
CGAGGACAACTACGCTATGATGAAGCTTGCCCGTGGTGTGTTCAAGACGACTCATATCGACCACTGTGCACGTCTGTGCC
ACTCCTCCACCGTTGCCGGTCTCGCAACCTCTTTTGGCTCCGGTGCAATGACCAACAGCATTCTTGATATCGAGCAGTCA
AAATGCCTCTTTATTCTTGGTTCCAACACCTTCGAGCAGCACCCGCTGATCGGACGCCGTGTAACCATGGCCAAGAAGAA
CGGTGCCAAGATCATCTACGCAGACCCGCGTTACACCCCGACCGGAAAGCAGGCAGATCTCTACATGCAGTTCCGCAGCG
GATCCGATGTGGCAATCCTCAACGGTCTGATGCAGCTCATCATCAAGAACGGCTGGGAAAACAAGGAATTCATTGCAAAC
CGTACAAAAGACTACGAAGCAATGAAAGAAATCGTCATGAAGGACACCTACTCGCCTGAAAATGTCGAGAAGATCTCCGG
TATCCCGGCAGCCCAGCTCAAGCAGGCAGCAGAGTGGATCGGAACCTCCGGCGCAACTGCCATCCTCTATTCCATGGGTA
TCACCCAGCACACCGTTGGTGTCGACAACGTTCACTCCGTCGCAAACATCCAGATGCTCTGCGGCAACCTCGGTCGCCCC
GGAACCGGTGTCAACGCACTTCGTGGACAGAACAATGTGCAGGGAGCCTGCGATATGGGAGCACTTCCAGTCAGCTTCAC
TGCATACCAGAAAGTCATCGACCCGGCTGCACACAAGAAATTCGAAGAAGGCTGGGGCTTCCCAGACGGTATCTGCGAAC
CGAAGAACGGTTACGAAGTCACCGTTATGATGGATGTCTTAACCGACAAGCCCGGAGAGCTCAAAGCACTCTACATCATG
GGTGAGAACCCGATGCTTTCCGATCCGGATCTGACTCACGTCAAGCACGCTCTTGAAGAAGTCGAGTTCATGGTCGTCCA
GGATATCTTCATGACCGAGACTGCCGAATTTGCAGACGTCGTTCTTCCGGCAACCTGCTACGCAGAACGTGACGGGACCC
AGACCTCGACCGAACGCCGTGTCCAGAAATGGAGAAAGGCACAGGATGCCCCCGGAGAGGCAAAACTCGACTGGGAAATC
ATCGCAATGGTCGCTGCAAAGATGGGCTACGCAGCCCAGTTCCCGTGGAAGACCTCCGAGGATGTCTTCAACGAGATGAG
AATGCTCACCCCGTCCTACCGCGGAATGACCTACGAAAGACTCGACAAACCCGAAGCACTTCACTGGCCATGCCCAGAAG
AGACCCACCCGGGAACTCCGATCCTTCACGGTGCAAAGTTTGCCCACCCGGATGGACTTGGTATTTTCTTCCCATGCGAG
TGGAAAGCACCTGCCGAGGTCCCGGACGCAGAGTATCCGTTCATCCTTACCACCGGCCGCTGTCTCTGGCACTGGCACAC
TGGTACCATGACCCGCAGATCCGACAGTCTTGACCACGAGGTCCCGACCGGATGGATCGAGATCAACACCGAAGACGCAG
CCGAACTCGGCATCACCGACGGTGAAAAGGTCAAAGCAATGACCCGCCGCGGCGAAGTCATTGTCGGTGCAAAAGTCACC
CCTGACATCATGAAAGGCGTTATGTTCATGCCCTTCCACTTCGTTGAATGTGCAGCAAACATGCTGACCAACAATGCACT
CGACCCGGTTTGTAAGATTCCGGAGTTCAAGGCATGTGCTGTGAAAGTTGAAAAGATTGCGGAGGCCTAA

Upstream 100 bases:

>100_bases
TCATGTAAACTAACACAAATTAATGTTAACTTAAAATACTAAGTCTGGATGAAGGTTAATATGGACAGTTTCAAACCTAT
ATTCATATGAGGTTTTACAC

Downstream 100 bases:

>100_bases
AAATGTCAGCAAAAGGCGATATGTTCTACGCATGGACTAACGTATCCGATATTAAAGGTGAATGCGGCGGAGCAGTAACC
TCAATTCTCAAGTACCTCCT

Product: formate dehydrogenase, alpha subunit (F420)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MTDLKYVTTTCPYCGTGCSFNLVVRDGKTVGVTPFTRSPVNEGKLCPKGMYAFEFVNSPDRLTTPLIKKDGKFVPASWDE
ATDYIAQKMKTFKPSEIACLASARTSNEDNYAMMKLARGVFKTTHIDHCARLCHSSTVAGLATSFGSGAMTNSILDIEQS
KCLFILGSNTFEQHPLIGRRVTMAKKNGAKIIYADPRYTPTGKQADLYMQFRSGSDVAILNGLMQLIIKNGWENKEFIAN
RTKDYEAMKEIVMKDTYSPENVEKISGIPAAQLKQAAEWIGTSGATAILYSMGITQHTVGVDNVHSVANIQMLCGNLGRP
GTGVNALRGQNNVQGACDMGALPVSFTAYQKVIDPAAHKKFEEGWGFPDGICEPKNGYEVTVMMDVLTDKPGELKALYIM
GENPMLSDPDLTHVKHALEEVEFMVVQDIFMTETAEFADVVLPATCYAERDGTQTSTERRVQKWRKAQDAPGEAKLDWEI
IAMVAAKMGYAAQFPWKTSEDVFNEMRMLTPSYRGMTYERLDKPEALHWPCPEETHPGTPILHGAKFAHPDGLGIFFPCE
WKAPAEVPDAEYPFILTTGRCLWHWHTGTMTRRSDSLDHEVPTGWIEINTEDAAELGITDGEKVKAMTRRGEVIVGAKVT
PDIMKGVMFMPFHFVECAANMLTNNALDPVCKIPEFKACAVKVEKIAEA

Sequences:

>Translated_689_residues
MTDLKYVTTTCPYCGTGCSFNLVVRDGKTVGVTPFTRSPVNEGKLCPKGMYAFEFVNSPDRLTTPLIKKDGKFVPASWDE
ATDYIAQKMKTFKPSEIACLASARTSNEDNYAMMKLARGVFKTTHIDHCARLCHSSTVAGLATSFGSGAMTNSILDIEQS
KCLFILGSNTFEQHPLIGRRVTMAKKNGAKIIYADPRYTPTGKQADLYMQFRSGSDVAILNGLMQLIIKNGWENKEFIAN
RTKDYEAMKEIVMKDTYSPENVEKISGIPAAQLKQAAEWIGTSGATAILYSMGITQHTVGVDNVHSVANIQMLCGNLGRP
GTGVNALRGQNNVQGACDMGALPVSFTAYQKVIDPAAHKKFEEGWGFPDGICEPKNGYEVTVMMDVLTDKPGELKALYIM
GENPMLSDPDLTHVKHALEEVEFMVVQDIFMTETAEFADVVLPATCYAERDGTQTSTERRVQKWRKAQDAPGEAKLDWEI
IAMVAAKMGYAAQFPWKTSEDVFNEMRMLTPSYRGMTYERLDKPEALHWPCPEETHPGTPILHGAKFAHPDGLGIFFPCE
WKAPAEVPDAEYPFILTTGRCLWHWHTGTMTRRSDSLDHEVPTGWIEINTEDAAELGITDGEKVKAMTRRGEVIVGAKVT
PDIMKGVMFMPFHFVECAANMLTNNALDPVCKIPEFKACAVKVEKIAEA
>Mature_688_residues
TDLKYVTTTCPYCGTGCSFNLVVRDGKTVGVTPFTRSPVNEGKLCPKGMYAFEFVNSPDRLTTPLIKKDGKFVPASWDEA
TDYIAQKMKTFKPSEIACLASARTSNEDNYAMMKLARGVFKTTHIDHCARLCHSSTVAGLATSFGSGAMTNSILDIEQSK
CLFILGSNTFEQHPLIGRRVTMAKKNGAKIIYADPRYTPTGKQADLYMQFRSGSDVAILNGLMQLIIKNGWENKEFIANR
TKDYEAMKEIVMKDTYSPENVEKISGIPAAQLKQAAEWIGTSGATAILYSMGITQHTVGVDNVHSVANIQMLCGNLGRPG
TGVNALRGQNNVQGACDMGALPVSFTAYQKVIDPAAHKKFEEGWGFPDGICEPKNGYEVTVMMDVLTDKPGELKALYIMG
ENPMLSDPDLTHVKHALEEVEFMVVQDIFMTETAEFADVVLPATCYAERDGTQTSTERRVQKWRKAQDAPGEAKLDWEII
AMVAAKMGYAAQFPWKTSEDVFNEMRMLTPSYRGMTYERLDKPEALHWPCPEETHPGTPILHGAKFAHPDGLGIFFPCEW
KAPAEVPDAEYPFILTTGRCLWHWHTGTMTRRSDSLDHEVPTGWIEINTEDAAELGITDGEKVKAMTRRGEVIVGAKVTP
DIMKGVMFMPFHFVECAANMLTNNALDPVCKIPEFKACAVKVEKIAEA

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=699, Percent_Identity=40.7725321888412, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1788534, Length=794, Percent_Identity=29.2191435768262, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI3868719, Length=618, Percent_Identity=30.7443365695793, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI3868720, Length=618, Percent_Identity=30.0970873786408, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1787778, Length=398, Percent_Identity=28.643216080402, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI87081797, Length=742, Percent_Identity=23.3153638814016, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1787870, Length=486, Percent_Identity=23.8683127572016, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI145693196, Length=673, Percent_Identity=21.6939078751857, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 76187; Mature: 76056

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLKYVTTTCPYCGTGCSFNLVVRDGKTVGVTPFTRSPVNEGKLCPKGMYAFEFVNSPD
CCCCEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCC
RLTTPLIKKDGKFVPASWDEATDYIAQKMKTFKPSEIACLASARTSNEDNYAMMKLARGV
HHCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHH
FKTTHIDHCARLCHSSTVAGLATSFGSGAMTNSILDIEQSKCLFILGSNTFEQHPLIGRR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEECCCCEEEEECCCCCCCCCCCCCE
VTMAKKNGAKIIYADPRYTPTGKQADLYMQFRSGSDVAILNGLMQLIIKNGWENKEFIAN
EEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHC
RTKDYEAMKEIVMKDTYSPENVEKISGIPAAQLKQAAEWIGTSGATAILYSMGITQHTVG
CCHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECC
VDNVHSVANIQMLCGNLGRPGTGVNALRGQNNVQGACDMGALPVSFTAYQKVIDPAAHKK
CCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHH
FEEGWGFPDGICEPKNGYEVTVMMDVLTDKPGELKALYIMGENPMLSDPDLTHVKHALEE
HHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
VEFMVVQDIFMTETAEFADVVLPATCYAERDGTQTSTERRVQKWRKAQDAPGEAKLDWEI
HHHHHHHHHHHHCHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
IAMVAAKMGYAAQFPWKTSEDVFNEMRMLTPSYRGMTYERLDKPEALHWPCPEETHPGTP
HHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
ILHGAKFAHPDGLGIFFPCEWKAPAEVPDAEYPFILTTGRCLWHWHTGTMTRRSDSLDHE
EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCC
VPTGWIEINTEDAAELGITDGEKVKAMTRRGEVIVGAKVTPDIMKGVMFMPFHFVECAAN
CCCCEEEECCCCHHHCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
MLTNNALDPVCKIPEFKACAVKVEKIAEA
HHHCCCCCHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TDLKYVTTTCPYCGTGCSFNLVVRDGKTVGVTPFTRSPVNEGKLCPKGMYAFEFVNSPD
CCCEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCC
RLTTPLIKKDGKFVPASWDEATDYIAQKMKTFKPSEIACLASARTSNEDNYAMMKLARGV
HHCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHH
FKTTHIDHCARLCHSSTVAGLATSFGSGAMTNSILDIEQSKCLFILGSNTFEQHPLIGRR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEECCCCEEEEECCCCCCCCCCCCCE
VTMAKKNGAKIIYADPRYTPTGKQADLYMQFRSGSDVAILNGLMQLIIKNGWENKEFIAN
EEEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHC
RTKDYEAMKEIVMKDTYSPENVEKISGIPAAQLKQAAEWIGTSGATAILYSMGITQHTVG
CCHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECC
VDNVHSVANIQMLCGNLGRPGTGVNALRGQNNVQGACDMGALPVSFTAYQKVIDPAAHKK
CCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHH
FEEGWGFPDGICEPKNGYEVTVMMDVLTDKPGELKALYIMGENPMLSDPDLTHVKHALEE
HHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
VEFMVVQDIFMTETAEFADVVLPATCYAERDGTQTSTERRVQKWRKAQDAPGEAKLDWEI
HHHHHHHHHHHHCHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
IAMVAAKMGYAAQFPWKTSEDVFNEMRMLTPSYRGMTYERLDKPEALHWPCPEETHPGTP
HHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
ILHGAKFAHPDGLGIFFPCEWKAPAEVPDAEYPFILTTGRCLWHWHTGTMTRRSDSLDHE
EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCCCCCCCCCC
VPTGWIEINTEDAAELGITDGEKVKAMTRRGEVIVGAKVTPDIMKGVMFMPFHFVECAAN
CCCCEEEECCCCHHHCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
MLTNNALDPVCKIPEFKACAVKVEKIAEA
HHHCCCCCHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3531194; 1378430 [H]