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The map label for this gene is chaA [C]

Identifier: 124266190

GI number: 124266190

Start: 1058221

End: 1059288

Strand: Reverse

Name: chaA [C]

Synonym: Mpe_A0997

Alternate gene names: 124266190

Gene position: 1059288-1058221 (Counterclockwise)

Preceding gene: 124266191

Following gene: 124266186

Centisome position: 26.19

GC content: 70.88

Gene sequence:

>1068_bases
ATGCCCCGTTGGGCCCTGCTCCTGCCGCTCGCCGCCGCTGCCCTGCTGGGAGCCTCGCTGGCCCTGCCGATGAACGCCGC
CATCGCCTCGGCCTGCGCCGTCGCCCTGATCGGCGCGGTGATCGCGGCAGTCCACCATGCCGAGGTCGTGGCGCACCGCG
TGGGCGAGCCGTTCGGCACGCTGGTGCTGGCGATCGCGATCACGGTGATCGAGGTGGCGCTCATCGTCTCCATGATGCTG
GCCGGCGGCGAGGGCAAGGCCGAGCTGCCGCGCGACACCATCTTCTCGGCGGTGATGATCATCTGCACCGGCGTGGTCGG
CATCTGTCTGCTGGTCGGCGGCCTGCACCACCACGAGCAGTCCTTCCAGCTCGACGGCGCGAACTCCGCGCTGGCGGCGC
TGGTGGCCATGGCGGGCCTCTCGCTGGTGCTGCCGTCCTTCACCACAAGCTCGGACGGCGGCACCTACACGATCTCGCAG
CTCACCTTCGTCGCGGTCTCCTCGCTGGTGCTGTGGGCGGTGTTCGTGTTCGTGCAGACGGTGCGCCACCGCGACTACTT
CCTGCCGCCGACGAATGCCGACGACGAGGACATCCACGCCAAGCCGCCGTCGAACGGCCAGGCCTGGGCCAGTTTCGGCC
TGCTGCTGATCGGCCTGGTGTCGGTGGTGGGGCTGGCCAAGCAGCTGTCGCCGACCATCGAGGCGGCGGTCGCGGCCGCG
GGCGCACCGAAGGCCGTGATCGGTATCGCGATCGCGCTGCTGGTGCTGCTGCCCGAGACCTGGGCCGCCGTGCGCGCCGC
CCGCGCCGATCGCCTGCAGACCAGCATGAACCTGGCGCTGGGCTCGGCGCTCGCCAGCATCGGACTGACCATCCCGGTGG
TCGTGGTGGCCGCGGTGCTGCTCGACCTGCCGCTGGTGCTGGGCCTGGCGGCCAAGGACCTCGTGCTGCTGCTGCTGACC
TTCATCGTGGGCGCCATCACGCTGGGGACCGGGCGGACCAACCTGATGCAGGGCGCCGTGCACCTGGTGCTGTTCGCGGC
CTTCCTGTTCCTCTCGCTGGTGCCCTGA

Upstream 100 bases:

>100_bases
CGCCCTGTGTCCGACTATCCTTCGCGCTTGCCTCCGGCGGCGTGATCGATCGTGTCGCGCCGCGCCGTTCCACCGCTCGC
GCCCCTGAAAGGACCGCCAT

Downstream 100 bases:

>100_bases
CAGGTCCCACGGCTCAGCGCGGCGCGGCCACCACCTCGCCTGCGCTGCTGACATCCACCCGCTGGTAGTCGGCGGCATAC
TTTTTTCGCATGCGCACCAG

Product: Ca2+/H+ antiporter

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MPRWALLLPLAAAALLGASLALPMNAAIASACAVALIGAVIAAVHHAEVVAHRVGEPFGTLVLAIAITVIEVALIVSMML
AGGEGKAELPRDTIFSAVMIICTGVVGICLLVGGLHHHEQSFQLDGANSALAALVAMAGLSLVLPSFTTSSDGGTYTISQ
LTFVAVSSLVLWAVFVFVQTVRHRDYFLPPTNADDEDIHAKPPSNGQAWASFGLLLIGLVSVVGLAKQLSPTIEAAVAAA
GAPKAVIGIAIALLVLLPETWAAVRAARADRLQTSMNLALGSALASIGLTIPVVVVAAVLLDLPLVLGLAAKDLVLLLLT
FIVGAITLGTGRTNLMQGAVHLVLFAAFLFLSLVP

Sequences:

>Translated_355_residues
MPRWALLLPLAAAALLGASLALPMNAAIASACAVALIGAVIAAVHHAEVVAHRVGEPFGTLVLAIAITVIEVALIVSMML
AGGEGKAELPRDTIFSAVMIICTGVVGICLLVGGLHHHEQSFQLDGANSALAALVAMAGLSLVLPSFTTSSDGGTYTISQ
LTFVAVSSLVLWAVFVFVQTVRHRDYFLPPTNADDEDIHAKPPSNGQAWASFGLLLIGLVSVVGLAKQLSPTIEAAVAAA
GAPKAVIGIAIALLVLLPETWAAVRAARADRLQTSMNLALGSALASIGLTIPVVVVAAVLLDLPLVLGLAAKDLVLLLLT
FIVGAITLGTGRTNLMQGAVHLVLFAAFLFLSLVP
>Mature_354_residues
PRWALLLPLAAAALLGASLALPMNAAIASACAVALIGAVIAAVHHAEVVAHRVGEPFGTLVLAIAITVIEVALIVSMMLA
GGEGKAELPRDTIFSAVMIICTGVVGICLLVGGLHHHEQSFQLDGANSALAALVAMAGLSLVLPSFTTSSDGGTYTISQL
TFVAVSSLVLWAVFVFVQTVRHRDYFLPPTNADDEDIHAKPPSNGQAWASFGLLLIGLVSVVGLAKQLSPTIEAAVAAAG
APKAVIGIAIALLVLLPETWAAVRAARADRLQTSMNLALGSALASIGLTIPVVVVAAVLLDLPLVLGLAAKDLVLLLLTF
IVGAITLGTGRTNLMQGAVHLVLFAAFLFLSLVP

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=338, Percent_Identity=35.207100591716, Blast_Score=191, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6320075, Length=312, Percent_Identity=22.7564102564103, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 36317; Mature: 36185

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRWALLLPLAAAALLGASLALPMNAAIASACAVALIGAVIAAVHHAEVVAHRVGEPFGT
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LVLAIAITVIEVALIVSMMLAGGEGKAELPRDTIFSAVMIICTGVVGICLLVGGLHHHEQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SFQLDGANSALAALVAMAGLSLVLPSFTTSSDGGTYTISQLTFVAVSSLVLWAVFVFVQT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VRHRDYFLPPTNADDEDIHAKPPSNGQAWASFGLLLIGLVSVVGLAKQLSPTIEAAVAAA
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAPKAVIGIAIALLVLLPETWAAVRAARADRLQTSMNLALGSALASIGLTIPVVVVAAVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDLPLVLGLAAKDLVLLLLTFIVGAITLGTGRTNLMQGAVHLVLFAAFLFLSLVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PRWALLLPLAAAALLGASLALPMNAAIASACAVALIGAVIAAVHHAEVVAHRVGEPFGT
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LVLAIAITVIEVALIVSMMLAGGEGKAELPRDTIFSAVMIICTGVVGICLLVGGLHHHEQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SFQLDGANSALAALVAMAGLSLVLPSFTTSSDGGTYTISQLTFVAVSSLVLWAVFVFVQT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VRHRDYFLPPTNADDEDIHAKPPSNGQAWASFGLLLIGLVSVVGLAKQLSPTIEAAVAAA
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAPKAVIGIAIALLVLLPETWAAVRAARADRLQTSMNLALGSALASIGLTIPVVVVAAVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDLPLVLGLAAKDLVLLLLTFIVGAITLGTGRTNLMQGAVHLVLFAAFLFLSLVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]