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The map label for this gene is groEL [H]

Identifier: 124266147

GI number: 124266147

Start: 1010259

End: 1011896

Strand: Direct

Name: groEL [H]

Synonym: Mpe_A0954

Alternate gene names: 124266147

Gene position: 1010259-1011896 (Clockwise)

Preceding gene: 124266146

Following gene: 124266148

Centisome position: 24.98

GC content: 71.86

Gene sequence:

>1638_bases
ATGCCCAACATCATGTTGCATGACGAAGAGGCACGCCTGGCGCTGGGCCGGGGTGTCGCGAAGCTGGCCAAGGCGGTCCG
CGGGACGCTGGGCCCGCGCGGCATGAACGCCATCATCGACCGCCCGATCGGCACGCCGATCATCTCGCGCGACGGTGTCA
GCATCGCCGCCGAGATCGAGCTCGAGGACCCGTTCGAGAACATCGGCGCGCAGGTGCTGCGCGAGGTCTCGAAGCAGACC
AACGAGATCGCCGGCGATGGCACCACCACGGCCACGGTGCTGGCCGATGCGCTGGTGCAGGACGGCCTGGCCTGCCTGGC
CAAAGGCGCGAATCCGGTGGAGCTGGTGGAAGGCCTGGAGCGCGGCGTGGCCGCGGCCATCGGGCTGCTGAAGTCGGCGG
CGACGCCGCTGGCGAACACCGAGGCCCTGCGCGCCGTGGCGGTGGTGGCGGCGAACGACGAGACGACCGGCCACCTGGTG
GCCGAGGCCCTGGAACGCGTGGGCGCCGACGGCATCGTCGACGTCGAGTTCGGCACCACCGTCGAGACGGTGCTGGACGT
GGTGGACGGCATGGCCTTCGACCGCGGCTACCTGTCGCACCACATGATCTCCGACGTCGAGAAGATGCAGGTGGTGCTGG
AGCAGCCACTGATCCTGATGACGGACCAGCGCCTGCAGACCCAGGAGGAGGTCGGGCTGCTGCTGCGACTGGCCGGCGAG
GCCAAGCGCCCGCTGCTCATCATCGCGGACGAGGTGGCTCCGGCGTGCATCGTCACGCTGCTGGCCTGGCGCGAGAAGTC
CGGCATCCCGGTGGCGGCCATCCATCCGCCCGAGTACGGACACTGGCGCAAGGCCATGCTGGAGGACATCTCCATCCTGA
CCGGTGGCCGCGTGATCGCGCGCGACCTTGGCGGCAGCCTGGGCGCGGTGGAACTGCGCGACCTGGGCCGCGCGCGCCAG
GTGCGGATCTCGTCCAACCAGACGGTCATCAGCGCCGGCGGTGGCGATCCGGCACTGATCGCCGCGCGCCGCCAGCAGGT
GGCACGCCAGCACGAACTGGCGCCGCCGAACATCGACAAGGACAAGCTCAAGGAGCGGCTGTCGAAGCTGTCGGGCGGGA
CCGCGCTGCTGCAGGTGGGCGGTGCGACGCCGGTGGAGCAGAAGCGCCGCCTCCACCTGGTGGAGGACGCCATCCACGCG
GCACGCGCTGCGGTCGCCGAAGGAGTGGTCCCCGGCGGCGGCCTGGCCCTGCTGCGGGTGTCGAGCGGGCTGGACGCCGA
GGTGGCGCGCAGCGAGGGTGCGGTGCGCGAAGGCGTGCGCCTGTTGCAGCGCGCGCTGCAGCAGCCGCTGCGCCACATCG
CCGCCAACGCCGGCCTCGACGGCCCGGCGGCGGTGCGCAAGGCGCTGGACTCGGCGCCGGGGGTCGGGCTCGACGCACGC
GACGGCCGCTTCGTCGACCTGGCGGCGGTCGGGATTATCGACCCGGTGAAGGTGAGCTACAGCGCCGTGCGCAATGCCGT
CTCGGTGGCGGCGCTGATCCTCACCACGCAGACGCTCATCGCCAAGAAGCCGGAAGACATGGACCCCACCGCGGGCCCGG
CGCTGGGCGGGGGTGCGGAGCGGCTGGGGCGGCAATGA

Upstream 100 bases:

>100_bases
GATGCAGTACGAATAGTGCCCCCGCCTGCGATGGGCGCCGCGGCGTCCATCGCAGGGGCACTTGAACAGCCAGCCACACG
AGAGACAGAGGAGACGAGCC

Downstream 100 bases:

>100_bases
CGCGTCGCCGGCGCACCCGGCTGATCTGCGGACTGGTGATCACGGGCGCAGGCCTCGTGATCGCCATCGCCGGACTCGTC
GGGCACTGGTTCTGACGGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 4; Protein Cpn60 4 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MPNIMLHDEEARLALGRGVAKLAKAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIELEDPFENIGAQVLREVSKQT
NEIAGDGTTTATVLADALVQDGLACLAKGANPVELVEGLERGVAAAIGLLKSAATPLANTEALRAVAVVAANDETTGHLV
AEALERVGADGIVDVEFGTTVETVLDVVDGMAFDRGYLSHHMISDVEKMQVVLEQPLILMTDQRLQTQEEVGLLLRLAGE
AKRPLLIIADEVAPACIVTLLAWREKSGIPVAAIHPPEYGHWRKAMLEDISILTGGRVIARDLGGSLGAVELRDLGRARQ
VRISSNQTVISAGGGDPALIAARRQQVARQHELAPPNIDKDKLKERLSKLSGGTALLQVGGATPVEQKRRLHLVEDAIHA
ARAAVAEGVVPGGGLALLRVSSGLDAEVARSEGAVREGVRLLQRALQQPLRHIAANAGLDGPAAVRKALDSAPGVGLDAR
DGRFVDLAAVGIIDPVKVSYSAVRNAVSVAALILTTQTLIAKKPEDMDPTAGPALGGGAERLGRQ

Sequences:

>Translated_545_residues
MPNIMLHDEEARLALGRGVAKLAKAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIELEDPFENIGAQVLREVSKQT
NEIAGDGTTTATVLADALVQDGLACLAKGANPVELVEGLERGVAAAIGLLKSAATPLANTEALRAVAVVAANDETTGHLV
AEALERVGADGIVDVEFGTTVETVLDVVDGMAFDRGYLSHHMISDVEKMQVVLEQPLILMTDQRLQTQEEVGLLLRLAGE
AKRPLLIIADEVAPACIVTLLAWREKSGIPVAAIHPPEYGHWRKAMLEDISILTGGRVIARDLGGSLGAVELRDLGRARQ
VRISSNQTVISAGGGDPALIAARRQQVARQHELAPPNIDKDKLKERLSKLSGGTALLQVGGATPVEQKRRLHLVEDAIHA
ARAAVAEGVVPGGGLALLRVSSGLDAEVARSEGAVREGVRLLQRALQQPLRHIAANAGLDGPAAVRKALDSAPGVGLDAR
DGRFVDLAAVGIIDPVKVSYSAVRNAVSVAALILTTQTLIAKKPEDMDPTAGPALGGGAERLGRQ
>Mature_544_residues
PNIMLHDEEARLALGRGVAKLAKAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIELEDPFENIGAQVLREVSKQTN
EIAGDGTTTATVLADALVQDGLACLAKGANPVELVEGLERGVAAAIGLLKSAATPLANTEALRAVAVVAANDETTGHLVA
EALERVGADGIVDVEFGTTVETVLDVVDGMAFDRGYLSHHMISDVEKMQVVLEQPLILMTDQRLQTQEEVGLLLRLAGEA
KRPLLIIADEVAPACIVTLLAWREKSGIPVAAIHPPEYGHWRKAMLEDISILTGGRVIARDLGGSLGAVELRDLGRARQV
RISSNQTVISAGGGDPALIAARRQQVARQHELAPPNIDKDKLKERLSKLSGGTALLQVGGATPVEQKRRLHLVEDAIHAA
RAAVAEGVVPGGGLALLRVSSGLDAEVARSEGAVREGVRLLQRALQQPLRHIAANAGLDGPAAVRKALDSAPGVGLDARD
GRFVDLAAVGIIDPVKVSYSAVRNAVSVAALILTTQTLIAKKPEDMDPTAGPALGGGAERLGRQ

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=523, Percent_Identity=38.0497131931166, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI31542947, Length=523, Percent_Identity=38.0497131931166, Blast_Score=355, Evalue=4e-98,
Organism=Escherichia coli, GI1790586, Length=519, Percent_Identity=43.9306358381503, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17555558, Length=522, Percent_Identity=37.5478927203065, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI193210679, Length=217, Percent_Identity=38.2488479262673, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17532603, Length=134, Percent_Identity=32.8358208955224, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=516, Percent_Identity=37.5968992248062, Blast_Score=348, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6322524, Length=191, Percent_Identity=28.7958115183246, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641193, Length=519, Percent_Identity=39.4990366088632, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24641191, Length=519, Percent_Identity=39.4990366088632, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI45550936, Length=517, Percent_Identity=37.137330754352, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI45550132, Length=517, Percent_Identity=37.137330754352, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI45550935, Length=517, Percent_Identity=37.137330754352, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI17864606, Length=532, Percent_Identity=35.3383458646617, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24584129, Length=521, Percent_Identity=32.2456813819578, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI19921262, Length=521, Percent_Identity=32.2456813819578, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24583944, Length=228, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57013; Mature: 56882

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIMLHDEEARLALGRGVAKLAKAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIE
CCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEEE
LEDPFENIGAQVLREVSKQTNEIAGDGTTTATVLADALVQDGLACLAKGANPVELVEGLE
ECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RGVAAAIGLLKSAATPLANTEALRAVAVVAANDETTGHLVAEALERVGADGIVDVEFGTT
HHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCH
VETVLDVVDGMAFDRGYLSHHMISDVEKMQVVLEQPLILMTDQRLQTQEEVGLLLRLAGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCC
AKRPLLIIADEVAPACIVTLLAWREKSGIPVAAIHPPEYGHWRKAMLEDISILTGGRVIA
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHH
RDLGGSLGAVELRDLGRARQVRISSNQTVISAGGGDPALIAARRQQVARQHELAPPNIDK
HHCCCCCCCHHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCH
DKLKERLSKLSGGTALLQVGGATPVEQKRRLHLVEDAIHAARAAVAEGVVPGGGLALLRV
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
SSGLDAEVARSEGAVREGVRLLQRALQQPLRHIAANAGLDGPAAVRKALDSAPGVGLDAR
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC
DGRFVDLAAVGIIDPVKVSYSAVRNAVSVAALILTTQTLIAKKPEDMDPTAGPALGGGAE
CCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
RLGRQ
HHCCC
>Mature Secondary Structure 
PNIMLHDEEARLALGRGVAKLAKAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIE
CCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEEE
LEDPFENIGAQVLREVSKQTNEIAGDGTTTATVLADALVQDGLACLAKGANPVELVEGLE
ECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RGVAAAIGLLKSAATPLANTEALRAVAVVAANDETTGHLVAEALERVGADGIVDVEFGTT
HHHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCH
VETVLDVVDGMAFDRGYLSHHMISDVEKMQVVLEQPLILMTDQRLQTQEEVGLLLRLAGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCC
AKRPLLIIADEVAPACIVTLLAWREKSGIPVAAIHPPEYGHWRKAMLEDISILTGGRVIA
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHH
RDLGGSLGAVELRDLGRARQVRISSNQTVISAGGGDPALIAARRQQVARQHELAPPNIDK
HHCCCCCCCHHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCH
DKLKERLSKLSGGTALLQVGGATPVEQKRRLHLVEDAIHAARAAVAEGVVPGGGLALLRV
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
SSGLDAEVARSEGAVREGVRLLQRALQQPLRHIAANAGLDGPAAVRKALDSAPGVGLDAR
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC
DGRFVDLAAVGIIDPVKVSYSAVRNAVSVAALILTTQTLIAKKPEDMDPTAGPALGGGAE
CCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
RLGRQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]