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The map label for this gene is mntH [H]

Identifier: 124266148

GI number: 124266148

Start: 1012038

End: 1013429

Strand: Direct

Name: mntH [H]

Synonym: Mpe_A0955

Alternate gene names: 124266148

Gene position: 1012038-1013429 (Clockwise)

Preceding gene: 124266147

Following gene: 124266149

Centisome position: 25.02

GC content: 68.1

Gene sequence:

>1392_bases
ATGACCAACCTCGAGCAAAGCGTGGACATGCGTTGGCGTGTCCCGGGACAGTGGCGCATGTTCGGCTTCATCGGGCCGGC
GGCCATGGTGAGCGTGGGCTACATGGACCCGGGCAACTGGGCCACCGACCTGGAGGGCGGCGCGCGCTTCGGCTATCAGC
TGCTGTGGGTGCTGCTGGCGTCGAACATCATCGCGGTGCTGCTGCAGAGTCTGGCCGCGCGGCTGGGCATCGTCGGTCGA
CTCGACCTCGCCCAGGCCTGCCGGGCCGGCTACTCGCGCCCGGTGTCGATGGCGCTGTGGGTGCTGTGCGAGCTGGCGAT
CATCGCCTGCGACCTGGCCGAGCTGCTGGGCAGCGCGATTGCACTCAACATGCTGTTCGGCATCCCGCTGCTATGGGGTG
TGGTCATCACCGCCTTCGACGTGATGCTCATCATGGTGCTGCAGCACTACGGCATCCGCAAGCTCGAGGCCGTGGTCGCC
GCACTGGTGCTCACCATCGGCGTGTGCATGGCGATCGAGATGGTGCTGGTGCAGCCGGTGCTCGGCGACATCGTCGGCGG
CCTGGTCCCGCGCATCGACGCCAACAGCCTGCTGGTCGCGATCGGCATCCTCGGCGCGACGGTGATGCCGCACAACCTCT
ACCTGCATTCGTCGCTGGTGCAGACGCGTCGCATCTCGCACACCCCCCAGGGCCAGCGCGAGGCCATCCGCTACAACTTC
GTCGACACGCTGCTGGCGCTGAACATCGCGTTCATCATCAATGCGTCGATCCTGGTGCTGTCGGCCTCGACCTTCTTCAC
GCAGGGCATCGAGGTCAATGAGCTCCAGCAGGCGCACAGCCTGCTGACGCCGCTGGTCGGCACCACGCTGGCGGCCACCG
TGTTCGCGATCGCACTGCTCGCCGCCGGCCAGAGCTCCACGCTCACCGGCACGCTGGCGGGCCAGGTGGTGATGGAGGGC
TTCCTGTCGCTGCGCATGAGCCCGCTGGCGCGCCGGCTGCTGACCCGCGGGCTGGCCATCGTGCCGGCCGTCGGGGTGCT
GCTCTACCAGGGCGATGCCGGCGTGCTGCAGCTGCTGATCATGAGCCAGGTGGTGCTGAGCCTGCAGCTGCCGTTCGCCA
TCGTGCCGCTGGTCCGGTTCACGAGCGATCGACAACTGATGGGTCAGTTCGCCAGCCCGCGCTGGGTCCGGGTCGCCGCC
TGGTCGGCCGCGGCCGGCATCGTGTCGCTGAACGCCTGGCTGGTGTGGCGCACGCTGGCTGCAGGTTCCGCGGACGGTGC
GCCCTGGTATGCCTACGTGCTGGTCGGTGCCTTGACGACCCTGCTGTTGTGGATCTCGTGCGTGCCCCTGAAACTGTCTG
CACCGGCGGTGCTGGAGGAGCGAGCTGCCTAG

Upstream 100 bases:

>100_bases
ACGGGCGCAGGCCTCGTGATCGCCATCGCCGGACTCGTCGGGCACTGGTTCTGACGGCCGGGATGTTGGGCGACAGGCAC
GACAAGAAGAAGGAGGGGAC

Downstream 100 bases:

>100_bases
GGTGCGGCCCCGATGGCAATGCAGGGGCGCGTGACGCCCAATCCCGGAACAAGCAAGGCGCGCTGAGGCACCACGCCCGG
ACGAGCCCGCAGGTCGGAGG

Product: manganese transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTNLEQSVDMRWRVPGQWRMFGFIGPAAMVSVGYMDPGNWATDLEGGARFGYQLLWVLLASNIIAVLLQSLAARLGIVGR
LDLAQACRAGYSRPVSMALWVLCELAIIACDLAELLGSAIALNMLFGIPLLWGVVITAFDVMLIMVLQHYGIRKLEAVVA
ALVLTIGVCMAIEMVLVQPVLGDIVGGLVPRIDANSLLVAIGILGATVMPHNLYLHSSLVQTRRISHTPQGQREAIRYNF
VDTLLALNIAFIINASILVLSASTFFTQGIEVNELQQAHSLLTPLVGTTLAATVFAIALLAAGQSSTLTGTLAGQVVMEG
FLSLRMSPLARRLLTRGLAIVPAVGVLLYQGDAGVLQLLIMSQVVLSLQLPFAIVPLVRFTSDRQLMGQFASPRWVRVAA
WSAAAGIVSLNAWLVWRTLAAGSADGAPWYAYVLVGALTTLLLWISCVPLKLSAPAVLEERAA

Sequences:

>Translated_463_residues
MTNLEQSVDMRWRVPGQWRMFGFIGPAAMVSVGYMDPGNWATDLEGGARFGYQLLWVLLASNIIAVLLQSLAARLGIVGR
LDLAQACRAGYSRPVSMALWVLCELAIIACDLAELLGSAIALNMLFGIPLLWGVVITAFDVMLIMVLQHYGIRKLEAVVA
ALVLTIGVCMAIEMVLVQPVLGDIVGGLVPRIDANSLLVAIGILGATVMPHNLYLHSSLVQTRRISHTPQGQREAIRYNF
VDTLLALNIAFIINASILVLSASTFFTQGIEVNELQQAHSLLTPLVGTTLAATVFAIALLAAGQSSTLTGTLAGQVVMEG
FLSLRMSPLARRLLTRGLAIVPAVGVLLYQGDAGVLQLLIMSQVVLSLQLPFAIVPLVRFTSDRQLMGQFASPRWVRVAA
WSAAAGIVSLNAWLVWRTLAAGSADGAPWYAYVLVGALTTLLLWISCVPLKLSAPAVLEERAA
>Mature_462_residues
TNLEQSVDMRWRVPGQWRMFGFIGPAAMVSVGYMDPGNWATDLEGGARFGYQLLWVLLASNIIAVLLQSLAARLGIVGRL
DLAQACRAGYSRPVSMALWVLCELAIIACDLAELLGSAIALNMLFGIPLLWGVVITAFDVMLIMVLQHYGIRKLEAVVAA
LVLTIGVCMAIEMVLVQPVLGDIVGGLVPRIDANSLLVAIGILGATVMPHNLYLHSSLVQTRRISHTPQGQREAIRYNFV
DTLLALNIAFIINASILVLSASTFFTQGIEVNELQQAHSLLTPLVGTTLAATVFAIALLAAGQSSTLTGTLAGQVVMEGF
LSLRMSPLARRLLTRGLAIVPAVGVLLYQGDAGVLQLLIMSQVVLSLQLPFAIVPLVRFTSDRQLMGQFASPRWVRVAAW
SAAAGIVSLNAWLVWRTLAAGSADGAPWYAYVLVGALTTLLLWISCVPLKLSAPAVLEERAA

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=448, Percent_Identity=37.0535714285714, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI295293167, Length=432, Percent_Identity=38.8888888888889, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI295293175, Length=432, Percent_Identity=38.8888888888889, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI295293173, Length=432, Percent_Identity=38.8888888888889, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI10835169, Length=432, Percent_Identity=38.8888888888889, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI295293178, Length=432, Percent_Identity=38.8888888888889, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI295293171, Length=432, Percent_Identity=38.8888888888889, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI295293169, Length=432, Percent_Identity=38.8888888888889, Blast_Score=252, Evalue=6e-67,
Organism=Escherichia coli, GI1788736, Length=397, Percent_Identity=40.5541561712846, Blast_Score=264, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI193210616, Length=471, Percent_Identity=34.1825902335456, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17569473, Length=424, Percent_Identity=34.6698113207547, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71999499, Length=413, Percent_Identity=34.3825665859564, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71993856, Length=215, Percent_Identity=40.9302325581395, Blast_Score=177, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6323062, Length=390, Percent_Identity=40, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321841, Length=410, Percent_Identity=39.2682926829268, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6324450, Length=417, Percent_Identity=36.9304556354916, Blast_Score=236, Evalue=6e-63,
Organism=Drosophila melanogaster, GI45553443, Length=409, Percent_Identity=35.9413202933985, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24648607, Length=409, Percent_Identity=35.9413202933985, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI281362176, Length=409, Percent_Identity=35.9413202933985, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24648609, Length=409, Percent_Identity=35.9413202933985, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 49617; Mature: 49486

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLEQSVDMRWRVPGQWRMFGFIGPAAMVSVGYMDPGNWATDLEGGARFGYQLLWVLLA
CCCCCCCCCCEEECCCCEEEEEEECHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
SNIIAVLLQSLAARLGIVGRLDLAQACRAGYSRPVSMALWVLCELAIIACDLAELLGSAI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNMLFGIPLLWGVVITAFDVMLIMVLQHYGIRKLEAVVAALVLTIGVCMAIEMVLVQPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIVGGLVPRIDANSLLVAIGILGATVMPHNLYLHSSLVQTRRISHTPQGQREAIRYNF
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VDTLLALNIAFIINASILVLSASTFFTQGIEVNELQQAHSLLTPLVGTTLAATVFAIALL
HHHHHHHHHHHHHHHHHHEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGQSSTLTGTLAGQVVMEGFLSLRMSPLARRLLTRGLAIVPAVGVLLYQGDAGVLQLLI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCHHHHHHHH
MSQVVLSLQLPFAIVPLVRFTSDRQLMGQFASPRWVRVAAWSAAAGIVSLNAWLVWRTLA
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
AGSADGAPWYAYVLVGALTTLLLWISCVPLKLSAPAVLEERAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
TNLEQSVDMRWRVPGQWRMFGFIGPAAMVSVGYMDPGNWATDLEGGARFGYQLLWVLLA
CCCCCCCCCEEECCCCEEEEEEECHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
SNIIAVLLQSLAARLGIVGRLDLAQACRAGYSRPVSMALWVLCELAIIACDLAELLGSAI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNMLFGIPLLWGVVITAFDVMLIMVLQHYGIRKLEAVVAALVLTIGVCMAIEMVLVQPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIVGGLVPRIDANSLLVAIGILGATVMPHNLYLHSSLVQTRRISHTPQGQREAIRYNF
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VDTLLALNIAFIINASILVLSASTFFTQGIEVNELQQAHSLLTPLVGTTLAATVFAIALL
HHHHHHHHHHHHHHHHHHEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGQSSTLTGTLAGQVVMEGFLSLRMSPLARRLLTRGLAIVPAVGVLLYQGDAGVLQLLI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCHHHHHHHH
MSQVVLSLQLPFAIVPLVRFTSDRQLMGQFASPRWVRVAAWSAAAGIVSLNAWLVWRTLA
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
AGSADGAPWYAYVLVGALTTLLLWISCVPLKLSAPAVLEERAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]