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The map label for this gene is adh [H]

Identifier: 124266129

GI number: 124266129

Start: 990481

End: 991524

Strand: Direct

Name: adh [H]

Synonym: Mpe_A0936

Alternate gene names: 124266129

Gene position: 990481-991524 (Clockwise)

Preceding gene: 124266128

Following gene: 124266140

Centisome position: 24.49

GC content: 70.11

Gene sequence:

>1044_bases
ATGAAGGCCGCCGTGCTGCACCAGTACAACGAGTCGCTGAGCGGCGACAGCTTCGTGCGCTACGGCGACGTGCCCGACCC
GAAGATCGAGAGCCCGACCGACGTCATCGTGCGCATCGGCGGTGCCGGCGTGTGCCGCACCGACCTGCACGTGGTCGAGG
GCCTGTGGCGCGGCAAGGTCGACGTCGAACTGCCCTACATCATGGGCCACGAGAACGCCGGCTGGATCGAGGCCGTGGGT
TCGGCGGTGAGCGGCATGAAGGTCGGCGACCCGGTGATCTGCCATCCGCTCGTGACCAGCGGCCACTGCCTGGCCTGCCG
CCGCGGCGACGACATGCACGCCGACGGCAGCCGCTTCCCCGGCATCAATGCCGACGGCGGCTATGCCGAGTACCTGCGCA
CGAACCAGCGCTCGCTGATCAAGCTGCCGTCGACGCTGGCGCCCAAGGATGTCGCGCCCTACACCGACGCCGGGCTCACC
GCCTACCGCGCCGCCAAGAAGGCCTCGCGCCACCTGCTGCCTGGCGAGTACGCGGTCGTCATCGGCGCCGGCGGGCTGGG
GCACATCGGCATCCAGGTGCTGGCGGCACTGTGCGCCGCCGAGATCATCGTCGTCGACCGCGCCGACGCCGCGCTGCAGC
TGGCCAAATCCTGCGGGGCCCACCATCTGGTGAAGGCGGACGAGCAGGCGTTGGAGCGCGTGCTCGAGCTCACCGAGGGG
AAGGGCGCCCAGGCGGTCATCGATTTCGTCGGCGAGGGCGAGGCCATCTCCAGGGGCCTGGCGATGACGCGCAACGCCGG
CACCTACTACGTCGTCGGCTACGGCGGACGGATCGAGCTGCCGTCGATCGACATGATCACCAGCGAGAAGAGCATCGTCG
GCAACCTGGTCGGCACGTATGCGGAGCTGGTCGAGCTGATGGCGCTGGCCGACCGCGGGCGGGTGCACCTGGCGACGCGC
GAGTACGCGCTGAAGGACGCCAACCAGGCGCTGCTCGACCTGCACCACGGCAGGATCCAGGGGCGCGCCGTGCTCGTGCC
CTGA

Upstream 100 bases:

>100_bases
CGCGACGAACGATGCCACACACATCCGGCAGAAGCTCGAAGACGGTCGACGCGAGTTGATCGCGCGCTGATCACCCCCCG
ACAGGACACCAGGAGACGCC

Downstream 100 bases:

>100_bases
ACGACGGCCCGCGGCCGCGGGCCGCGTCGGCGTCAGCAGGGGCGTCGGCGCGCGTACACGCGCGGCACGGCGAAGTCGCG
GCCCACCAGCGCGCGCGCAT

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKAAVLHQYNESLSGDSFVRYGDVPDPKIESPTDVIVRIGGAGVCRTDLHVVEGLWRGKVDVELPYIMGHENAGWIEAVG
SAVSGMKVGDPVICHPLVTSGHCLACRRGDDMHADGSRFPGINADGGYAEYLRTNQRSLIKLPSTLAPKDVAPYTDAGLT
AYRAAKKASRHLLPGEYAVVIGAGGLGHIGIQVLAALCAAEIIVVDRADAALQLAKSCGAHHLVKADEQALERVLELTEG
KGAQAVIDFVGEGEAISRGLAMTRNAGTYYVVGYGGRIELPSIDMITSEKSIVGNLVGTYAELVELMALADRGRVHLATR
EYALKDANQALLDLHHGRIQGRAVLVP

Sequences:

>Translated_347_residues
MKAAVLHQYNESLSGDSFVRYGDVPDPKIESPTDVIVRIGGAGVCRTDLHVVEGLWRGKVDVELPYIMGHENAGWIEAVG
SAVSGMKVGDPVICHPLVTSGHCLACRRGDDMHADGSRFPGINADGGYAEYLRTNQRSLIKLPSTLAPKDVAPYTDAGLT
AYRAAKKASRHLLPGEYAVVIGAGGLGHIGIQVLAALCAAEIIVVDRADAALQLAKSCGAHHLVKADEQALERVLELTEG
KGAQAVIDFVGEGEAISRGLAMTRNAGTYYVVGYGGRIELPSIDMITSEKSIVGNLVGTYAELVELMALADRGRVHLATR
EYALKDANQALLDLHHGRIQGRAVLVP
>Mature_347_residues
MKAAVLHQYNESLSGDSFVRYGDVPDPKIESPTDVIVRIGGAGVCRTDLHVVEGLWRGKVDVELPYIMGHENAGWIEAVG
SAVSGMKVGDPVICHPLVTSGHCLACRRGDDMHADGSRFPGINADGGYAEYLRTNQRSLIKLPSTLAPKDVAPYTDAGLT
AYRAAKKASRHLLPGEYAVVIGAGGLGHIGIQVLAALCAAEIIVVDRADAALQLAKSCGAHHLVKADEQALERVLELTEG
KGAQAVIDFVGEGEAISRGLAMTRNAGTYYVVGYGGRIELPSIDMITSEKSIVGNLVGTYAELVELMALADRGRVHLATR
EYALKDANQALLDLHHGRIQGRAVLVP

Specific function: Converts Galactitol 1-Phosphate To Tagatose 6-Phosphate. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=25.7575757575758, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI262073058, Length=309, Percent_Identity=29.126213592233, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=309, Percent_Identity=29.126213592233, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501933, Length=302, Percent_Identity=28.1456953642384, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4501929, Length=297, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI34577061, Length=304, Percent_Identity=27.6315789473684, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501939, Length=324, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI156523966, Length=324, Percent_Identity=25, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1788407, Length=245, Percent_Identity=29.3877551020408, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=29.1139240506329, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082401, Length=328, Percent_Identity=29.2682926829268, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082125, Length=297, Percent_Identity=29.6296296296296, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788075, Length=318, Percent_Identity=30.188679245283, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790045, Length=348, Percent_Identity=26.4367816091954, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786825, Length=363, Percent_Identity=28.099173553719, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787863, Length=262, Percent_Identity=27.4809160305344, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=288, Percent_Identity=24.6527777777778, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788073, Length=320, Percent_Identity=26.875, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790718, Length=306, Percent_Identity=26.4705882352941, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1786518, Length=297, Percent_Identity=28.6195286195286, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=343, Percent_Identity=26.530612244898, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=27.4052478134111, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=330, Percent_Identity=26.3636363636364, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=26.4957264957265, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=316, Percent_Identity=24.3670886075949, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=29.4117647058824, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323961, Length=353, Percent_Identity=28.0453257790368, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=28.6567164179104, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=27.4626865671642, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=327, Percent_Identity=26.9113149847095, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=27.1341463414634, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=328, Percent_Identity=27.1341463414634, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=315, Percent_Identity=27.3015873015873, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=337, Percent_Identity=24.3323442136499, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323980, Length=344, Percent_Identity=25.2906976744186, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=327, Percent_Identity=26.9113149847095, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17737897, Length=327, Percent_Identity=26.9113149847095, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36847; Mature: 36847

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVLHQYNESLSGDSFVRYGDVPDPKIESPTDVIVRIGGAGVCRTDLHVVEGLWRGKV
CCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHCCCE
DVELPYIMGHENAGWIEAVGSAVSGMKVGDPVICHPLVTSGHCLACRRGDDMHADGSRFP
EEEECEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCC
GINADGGYAEYLRTNQRSLIKLPSTLAPKDVAPYTDAGLTAYRAAKKASRHLLPGEYAVV
CCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
IGAGGLGHIGIQVLAALCAAEIIVVDRADAALQLAKSCGAHHLVKADEQALERVLELTEG
EECCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCC
KGAQAVIDFVGEGEAISRGLAMTRNAGTYYVVGYGGRIELPSIDMITSEKSIVGNLVGTY
CCCEEEHEECCCCHHHHHCHHEEECCCEEEEEEECCEEECCCCEEECCCHHHHHHHHHHH
AELVELMALADRGRVHLATREYALKDANQALLDLHHGRIQGRAVLVP
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MKAAVLHQYNESLSGDSFVRYGDVPDPKIESPTDVIVRIGGAGVCRTDLHVVEGLWRGKV
CCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHCCCE
DVELPYIMGHENAGWIEAVGSAVSGMKVGDPVICHPLVTSGHCLACRRGDDMHADGSRFP
EEEECEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCC
GINADGGYAEYLRTNQRSLIKLPSTLAPKDVAPYTDAGLTAYRAAKKASRHLLPGEYAVV
CCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
IGAGGLGHIGIQVLAALCAAEIIVVDRADAALQLAKSCGAHHLVKADEQALERVLELTEG
EECCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCC
KGAQAVIDFVGEGEAISRGLAMTRNAGTYYVVGYGGRIELPSIDMITSEKSIVGNLVGTY
CCCEEEHEECCCCHHHHHCHHEEECCCEEEEEEECCEEECCCCEEECCCHHHHHHHHHHH
AELVELMALADRGRVHLATREYALKDANQALLDLHHGRIQGRAVLVP
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]