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The map label for this gene is cobW [H]

Identifier: 124266140

GI number: 124266140

Start: 1003197

End: 1004210

Strand: Direct

Name: cobW [H]

Synonym: Mpe_A0947

Alternate gene names: 124266140

Gene position: 1003197-1004210 (Clockwise)

Preceding gene: 124266129

Following gene: 124266141

Centisome position: 24.81

GC content: 69.13

Gene sequence:

>1014_bases
ATGACTTCGAGAATTCCAGTCACCGTGATCACCGGCTTCCTCGGCGCCGGCAAGACGACCTTGCTCAATCGCATCCTGCA
AGGCGCGGCCGGCAAGCGCTACGCCGTCATCGTCAACGAGTTCGGCGAACTCGGCATCGACGGCTCGCTGGTCGTCGGCG
CCGAGGAAGAGGTGCACGAGCTGAACAACGGCTGCGTCTGCTGCCGGGTGCGCGGCGACCTCATCCGCGTCATGAGCGGC
CTCATCCGCCGGCCGGGTCGCTTCGACGGCATCATCATCGAGACCAGCGGCCTGGCCGATCCGGCGCCGGTCATCCAGAC
GCTGCACTTCGACGACTTCCTGCGCCAGCACACCCAGCCGGACAGCGTGATCTGCGTGGCCGACGCGCGCCACCTCGCGA
GGCAACTGCAGGCCGCGCCGGAGGCCGGCGCGCAACTGGCGCAGGCCGACCTGGTCTTGCTGAACAAGTGCGATCTCGCG
AAGGCCGACGAGCTGGCCGTCTCCGAGATCGCCGTGGAGCGCGTGAACCCGACCGCCGAGGTGGTCCGCTGCGAGCGAGG
CGACATCGAGCTCGACCGCCTGATCGGCCGCGGCGCCTTCGACCTCTCTCGCCTGCGGGTGCCGCCGCTGCAGATCCAGC
GAGGCCGCATCGGCCGCGTGCCGCATGCCTACGTCGAGGTCGAGGAGGGCCGGCACGGCGACGGCCTGCGCTGCGTGTCG
CTGAGCATCGAGCAGGCGTTCGACCCGAGCCTGTTCGTCGGCTGGCTGCTGCGCTTCGTTCGCGAGAACGGCGAGCACCT
GCTGCGCGGCAAGGGCATCGTGTCGCTGCGTGGCAGCGAGAAGCGCTTCGTCTTCCAGACCGTGCACATGACGGTCGACA
GCGGCATGGACCGCGCCTGGAAGGACGGTGAGCCGAGGGGGTCGCGGCTGGTGTTCATCGGTCGCGACCTGAGCGCGATC
GCGCTGCGCGAGCAGTTGGAAGCGTGCCTTGCGCAAGTCGAGGTGACGCCGTGA

Upstream 100 bases:

>100_bases
GGCGACCCTCGGACCGCATCGCGGGCGATCGGGGATGGACACGAAGACCGTGGCAGGCGGGCGCACAACCCCGAACCGCG
GCAGACCAAAGGACCGCAGC

Downstream 100 bases:

>100_bases
TGCCGTCGACACCGTGCCGGAGGAACCTGCCATGAACCCGCCTCTGCTCGACGTGCTGGGCACGCAATGGGACATGACGG
CCCCGGTCGTCTCGATCTCC

Product: putative CobW protein involved in cobalamin synthesis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTSRIPVTVITGFLGAGKTTLLNRILQGAAGKRYAVIVNEFGELGIDGSLVVGAEEEVHELNNGCVCCRVRGDLIRVMSG
LIRRPGRFDGIIIETSGLADPAPVIQTLHFDDFLRQHTQPDSVICVADARHLARQLQAAPEAGAQLAQADLVLLNKCDLA
KADELAVSEIAVERVNPTAEVVRCERGDIELDRLIGRGAFDLSRLRVPPLQIQRGRIGRVPHAYVEVEEGRHGDGLRCVS
LSIEQAFDPSLFVGWLLRFVRENGEHLLRGKGIVSLRGSEKRFVFQTVHMTVDSGMDRAWKDGEPRGSRLVFIGRDLSAI
ALREQLEACLAQVEVTP

Sequences:

>Translated_337_residues
MTSRIPVTVITGFLGAGKTTLLNRILQGAAGKRYAVIVNEFGELGIDGSLVVGAEEEVHELNNGCVCCRVRGDLIRVMSG
LIRRPGRFDGIIIETSGLADPAPVIQTLHFDDFLRQHTQPDSVICVADARHLARQLQAAPEAGAQLAQADLVLLNKCDLA
KADELAVSEIAVERVNPTAEVVRCERGDIELDRLIGRGAFDLSRLRVPPLQIQRGRIGRVPHAYVEVEEGRHGDGLRCVS
LSIEQAFDPSLFVGWLLRFVRENGEHLLRGKGIVSLRGSEKRFVFQTVHMTVDSGMDRAWKDGEPRGSRLVFIGRDLSAI
ALREQLEACLAQVEVTP
>Mature_336_residues
TSRIPVTVITGFLGAGKTTLLNRILQGAAGKRYAVIVNEFGELGIDGSLVVGAEEEVHELNNGCVCCRVRGDLIRVMSGL
IRRPGRFDGIIIETSGLADPAPVIQTLHFDDFLRQHTQPDSVICVADARHLARQLQAAPEAGAQLAQADLVLLNKCDLAK
ADELAVSEIAVERVNPTAEVVRCERGDIELDRLIGRGAFDLSRLRVPPLQIQRGRIGRVPHAYVEVEEGRHGDGLRCVSL
SIEQAFDPSLFVGWLLRFVRENGEHLLRGKGIVSLRGSEKRFVFQTVHMTVDSGMDRAWKDGEPRGSRLVFIGRDLSAIA
LREQLEACLAQVEVTP

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=354, Percent_Identity=32.4858757062147, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI126722884, Length=354, Percent_Identity=32.4858757062147, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI148727351, Length=354, Percent_Identity=32.4858757062147, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI146231952, Length=349, Percent_Identity=32.6647564469914, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI223941779, Length=354, Percent_Identity=31.9209039548023, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI223941776, Length=342, Percent_Identity=31.2865497076023, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI119120938, Length=348, Percent_Identity=30.1724137931034, Blast_Score=134, Evalue=9e-32,
Organism=Escherichia coli, GI87082430, Length=323, Percent_Identity=32.1981424148607, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1788499, Length=170, Percent_Identity=34.7058823529412, Blast_Score=89, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=227, Percent_Identity=31.7180616740088, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 36934; Mature: 36803

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRIPVTVITGFLGAGKTTLLNRILQGAAGKRYAVIVNEFGELGIDGSLVVGAEEEVHE
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCCCEEECCHHHHHH
LNNGCVCCRVRGDLIRVMSGLIRRPGRFDGIIIETSGLADPAPVIQTLHFDDFLRQHTQP
HCCCEEEEEECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
DSVICVADARHLARQLQAAPEAGAQLAQADLVLLNKCDLAKADELAVSEIAVERVNPTAE
CCEEEEHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCHHH
VVRCERGDIELDRLIGRGAFDLSRLRVPPLQIQRGRIGRVPHAYVEVEEGRHGDGLRCVS
HEECCCCCCHHHHHHCCCCCCHHHHCCCCHHCCCCCCCCCCEEEEEEECCCCCCCEEEEE
LSIEQAFDPSLFVGWLLRFVRENGEHLLRGKGIVSLRGSEKRFVFQTVHMTVDSGMDRAW
EEHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCEEEEEEEEEHHHCCCCCCC
KDGEPRGSRLVFIGRDLSAIALREQLEACLAQVEVTP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSRIPVTVITGFLGAGKTTLLNRILQGAAGKRYAVIVNEFGELGIDGSLVVGAEEEVHE
CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCCCEEECCHHHHHH
LNNGCVCCRVRGDLIRVMSGLIRRPGRFDGIIIETSGLADPAPVIQTLHFDDFLRQHTQP
HCCCEEEEEECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
DSVICVADARHLARQLQAAPEAGAQLAQADLVLLNKCDLAKADELAVSEIAVERVNPTAE
CCEEEEHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCHHH
VVRCERGDIELDRLIGRGAFDLSRLRVPPLQIQRGRIGRVPHAYVEVEEGRHGDGLRCVS
HEECCCCCCHHHHHHCCCCCCHHHHCCCCHHCCCCCCCCCCEEEEEEECCCCCCCEEEEE
LSIEQAFDPSLFVGWLLRFVRENGEHLLRGKGIVSLRGSEKRFVFQTVHMTVDSGMDRAW
EEHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCEEEEEEEEEHHHCCCCCCC
KDGEPRGSRLVFIGRDLSAIALREQLEACLAQVEVTP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]