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The map label for this gene is lip2 [H]

Identifier: 124266083

GI number: 124266083

Start: 935153

End: 936085

Strand: Direct

Name: lip2 [H]

Synonym: Mpe_A0890

Alternate gene names: 124266083

Gene position: 935153-936085 (Clockwise)

Preceding gene: 124266082

Following gene: 124266084

Centisome position: 23.12

GC content: 67.52

Gene sequence:

>933_bases
ATGTCACTGGACCCGCAAGTACAAGGATTGCTCGATGCGTTCAAGGCGCAGGGCCTGAAGAGCTTCGAGCAGATGACGGT
GCCCGAATCCCGCGAGACTGCCATGGCCTTCGTCGGCCTGGAAGGCGACGAGGAGGCGGTAGCCGATGTGTCGAATCACC
GTGTGCCGGTGAAGGGCGGCGACATCGCCGTGCGCATCTACCGGCCAGCGGGCAACGCACCGCACCCGATGCTGGTTTAC
TTCCACGGCGGCGGCTTCGTGTTCGGCAACCTGGATCTGGTCGACAAGGTCGCCCGCTCGCTGTGCAACGCGTCCAATGC
GGCGGTGGTCTCGGTCGACTACCGCAAGGCACCCGAGCACCCCTATCCCACGGCGCCGGAGGATGCCTACGCCGGCCTGG
TGTGGGCGCGCGAGAACGCCGCGAAGCTGGGGCTCGATCCGGCCCGCATCGCGGTGGCCGGCGACAGCGCCGGTGGCAAC
CTCGCGGCGGTCGTGTCGCAGATGGCACGTGACCGCAAGGGCCCGAAGATCGCCCACCAGGTGCTGGTCTACCCGGTCAC
CGACGCGGCGGGCGACTACCCCTCGCGCAAGGAAAACGCCGAAGGCTACCTGCTGACCCAGGGTGCGATGAACTGGTTCT
TCGGCCATTACCTGACGAGTCCCGGCCTGGCGAGCGACGCCTATGTCTCGCCGATCAAGGGGGATCTCAAGGGCCTGCCC
GCCGCCACCGTGATCACCGCCGGCTACGACCCGCTGCGCGACGAGGGCGATGCCTACGCCAAGGCGCTGGCGAAGGCCGG
TGTGGCGGTCGACCACGTGCCCAACCCGACGATGATCCACGGCTTCTTCTGGATGAAGGGCGTGATCGGCCACACGCAGA
GCATCTACGACCGCGTCGGCAGGAACCTGAAGGCCGCGTTCGGGACCGCCTGA

Upstream 100 bases:

>100_bases
CCCAGCGTCTACGACAAGTACCTGACCACTTCCGCGATGCAGCGGCTGGGCAACTGAAGCCCGGTCTCTGCGCTTCTTCA
CCACCCCCAAGGAGACGACG

Downstream 100 bases:

>100_bases
ATGCCGCCGGTTTCGACGCGCAGCTGAGGAGGGCGGTCATGCCGGCAACGGGCCCGGGCCCCGGTCCGTTGCGCGGCGTG
CGCGTGGTCGAGTTCGCTGC

Product: putative lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSLDPQVQGLLDAFKAQGLKSFEQMTVPESRETAMAFVGLEGDEEAVADVSNHRVPVKGGDIAVRIYRPAGNAPHPMLVY
FHGGGFVFGNLDLVDKVARSLCNASNAAVVSVDYRKAPEHPYPTAPEDAYAGLVWARENAAKLGLDPARIAVAGDSAGGN
LAAVVSQMARDRKGPKIAHQVLVYPVTDAAGDYPSRKENAEGYLLTQGAMNWFFGHYLTSPGLASDAYVSPIKGDLKGLP
AATVITAGYDPLRDEGDAYAKALAKAGVAVDHVPNPTMIHGFFWMKGVIGHTQSIYDRVGRNLKAAFGTA

Sequences:

>Translated_310_residues
MSLDPQVQGLLDAFKAQGLKSFEQMTVPESRETAMAFVGLEGDEEAVADVSNHRVPVKGGDIAVRIYRPAGNAPHPMLVY
FHGGGFVFGNLDLVDKVARSLCNASNAAVVSVDYRKAPEHPYPTAPEDAYAGLVWARENAAKLGLDPARIAVAGDSAGGN
LAAVVSQMARDRKGPKIAHQVLVYPVTDAAGDYPSRKENAEGYLLTQGAMNWFFGHYLTSPGLASDAYVSPIKGDLKGLP
AATVITAGYDPLRDEGDAYAKALAKAGVAVDHVPNPTMIHGFFWMKGVIGHTQSIYDRVGRNLKAAFGTA
>Mature_309_residues
SLDPQVQGLLDAFKAQGLKSFEQMTVPESRETAMAFVGLEGDEEAVADVSNHRVPVKGGDIAVRIYRPAGNAPHPMLVYF
HGGGFVFGNLDLVDKVARSLCNASNAAVVSVDYRKAPEHPYPTAPEDAYAGLVWARENAAKLGLDPARIAVAGDSAGGNL
AAVVSQMARDRKGPKIAHQVLVYPVTDAAGDYPSRKENAEGYLLTQGAMNWFFGHYLTSPGLASDAYVSPIKGDLKGLPA
ATVITAGYDPLRDEGDAYAKALAKAGVAVDHVPNPTMIHGFFWMKGVIGHTQSIYDRVGRNLKAAFGTA

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=354, Percent_Identity=28.5310734463277, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI68299767, Length=213, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI157041239, Length=165, Percent_Identity=34.5454545454545, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI61966717, Length=166, Percent_Identity=31.3253012048193, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI157041237, Length=124, Percent_Identity=34.6774193548387, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI68051721, Length=185, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21328446, Length=93, Percent_Identity=40.8602150537634, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI226423947, Length=193, Percent_Identity=28.4974093264249, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1786682, Length=234, Percent_Identity=29.0598290598291, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17567059, Length=289, Percent_Identity=30.7958477508651, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71996133, Length=204, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI72001146, Length=130, Percent_Identity=37.6923076923077, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17540028, Length=157, Percent_Identity=31.8471337579618, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI115533410, Length=96, Percent_Identity=36.4583333333333, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24656084, Length=90, Percent_Identity=38.8888888888889, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24656076, Length=90, Percent_Identity=38.8888888888889, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20130169, Length=90, Percent_Identity=38.8888888888889, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32925; Mature: 32793

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01174 LIPASE_GDXG_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDPQVQGLLDAFKAQGLKSFEQMTVPESRETAMAFVGLEGDEEAVADVSNHRVPVKGG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCEEEECCC
DIAVRIYRPAGNAPHPMLVYFHGGGFVFGNLDLVDKVARSLCNASNAAVVSVDYRKAPEH
CEEEEEECCCCCCCCCEEEEEECCEEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
PYPTAPEDAYAGLVWARENAAKLGLDPARIAVAGDSAGGNLAAVVSQMARDRKGPKIAHQ
CCCCCCCHHHEEEEEECCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
VLVYPVTDAAGDYPSRKENAEGYLLTQGAMNWFFGHYLTSPGLASDAYVSPIKGDLKGLP
EEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCC
AATVITAGYDPLRDEGDAYAKALAKAGVAVDHVPNPTMIHGFFWMKGVIGHTQSIYDRVG
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEECCCCCCEEEHHHHHHHHHCCHHHHHHHHC
RNLKAAFGTA
CCHHHHCCCC
>Mature Secondary Structure 
SLDPQVQGLLDAFKAQGLKSFEQMTVPESRETAMAFVGLEGDEEAVADVSNHRVPVKGG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCEEEECCC
DIAVRIYRPAGNAPHPMLVYFHGGGFVFGNLDLVDKVARSLCNASNAAVVSVDYRKAPEH
CEEEEEECCCCCCCCCEEEEEECCEEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
PYPTAPEDAYAGLVWARENAAKLGLDPARIAVAGDSAGGNLAAVVSQMARDRKGPKIAHQ
CCCCCCCHHHEEEEEECCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
VLVYPVTDAAGDYPSRKENAEGYLLTQGAMNWFFGHYLTSPGLASDAYVSPIKGDLKGLP
EEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCC
AATVITAGYDPLRDEGDAYAKALAKAGVAVDHVPNPTMIHGFFWMKGVIGHTQSIYDRVG
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEECCCCCCEEEHHHHHHHHHCCHHHHHHHHC
RNLKAAFGTA
CCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]