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The map label for this gene is aceE [H]

Identifier: 124266067

GI number: 124266067

Start: 913034

End: 915709

Strand: Direct

Name: aceE [H]

Synonym: Mpe_A0874

Alternate gene names: 124266067

Gene position: 913034-915709 (Clockwise)

Preceding gene: 124266065

Following gene: 124266069

Centisome position: 22.58

GC content: 72.27

Gene sequence:

>2676_bases
ATGACCCAAGTGTTCGAACCCCTGCTGTTCCAGGCCGCCGCCGCCGACACCGATCCCGCCGAGACCGCCGAGTGGCGCGA
TGCCCTGGCCGCGGTGCTGGCCGCCGCCGGGCCGGAGCGCGCGCGTTTCCTGCTGGACCAGCTGGCCGCGCAGGCCAGCG
AGCCCGCCATCGCCTGGCAGCCGCGCGGCGGCGGCTCGCCCTACGTCAACACCATCCCGGTCGAGCGCCAGCCGCGCTTC
CCCGGCGATCTGGCGATCGAGGAGCGCCTGGCCTCCCTGATGCGCTGGAACGCGCTGGCGATGGTGGTGCGCGCCAATCA
GGCCTACGGCGAACTCGGCGGCCACATCGCCAGCTACGCGAGCGCGGCCGATCTGTTCGAGGTCGGCTTCAACCACTTCT
TCCGCGCGCGCAACGCGCAGCAGGGTGGCGACCTGGTGTTCTACCAGCCGCACTCGGCGCCCGGCGTCTACGCGCGTGCC
TTCCTCGAAGGCCGCCTGAGCGAGGCCGACCTGGCCCACTACCGGCAGGAGCTCGCCGCGCCGGCGGCCGGCGCGCAGGG
CCTGTCGAGCTATCCGCATCCGTGGCTGATGCCCGAGTTCTGGCAGTTCCCCACCGGCTCGATGGGCATCGGCCCCATCA
GCTCGATCTACCAGGCGCGCTTCATGCGCTACCTGCAGCACCGCGGGCTGCTGCAGACCGAGGGCCGCCGCGTCTGGGGC
GTGTTCGGCGACGGCGAGATGGACGAGCCCGAGAGCATGAGCGCGCTCACGCTCGCCGCGCGCGAAAAGCTCGACAACCT
CACATGGGTGATCAACTGCAACCTGCAGCGCCTGGACGGCCCGGTGCGCGGCAACGGCCGCATCATCGACGAGCTGGAGG
CGCTGTTCGCCGGCGCCGGCTGGCAGGTCATCAAGCTGGTGTGGGGCTCCGACTGGGACGGCCTGTTCGCGCGCGACACC
CACGGTGCGCTGCGCAAGGCCTTCGCCGGCACCGTGGACGGCCAGTTCCAGACCTTCGCCGCCAAGGACGGCCGCTACAA
CCGCGAGCACTTCTTCGGCCAGACCCCCGAGCTCGCCGCGCTGGCCCAGGGCCTGACCGACGAGCAGATCGACCGGCTGC
GCCGCGGCGGCCACGACATGGTGAAGATCCACGCCGCCTACCACGCGGCGATGCAGTGCCGCGGCCGGCCGGTGGTGATC
CTGGCGCAGACCAAGAAGGGCTACGGCATGGGCGAGGCCGGGCAGGGCCGCATGACCACGCACCAGCAGAAGAAGCTCGA
CCGCGACGACCTGATCGCCTTCCGCAACCGCTTCGCGCTGCCGCTCAGCGACGAGCAGGCCGCGAGCCTGGCGTTCTACA
AGCCGGCCGACGACAGCCCCGAGATGCGTTACCTGCACGCGCGCCGCGCCGCGCTGGGCGGCCAGATCCCGGCGCGGGTG
GCGCAGGCGCCGCAGCTGGCGGTGCCGCCGGTGGCGCGCTGGGGTGACTTCGCGCTGAACGCCGACGGCAAGGAGATGAG
CACCACCATGGCCTTCGTGCGCATGCTCACCGCGCTGCTGAAGGACGCGCAGCTCGGCCCGCGCATCGTGCCCATCGTCG
CCGACGAGGCGCGCACCTTCGGCATGGCCAACCTGTTCAAGCAGATCGGCATCTACTCCAACCTCGGCCAGAACTACGAG
CCCGAGGACATCGGCTCGGTGCTCAGCTACCGCGAGGCCACCGACGGCCAGATCCTGGAGGAGGGCATCAGCGAGGCCGG
TGCGCTGAGCTCCTGGGTGGCCGCGGCCACCAGCTACAGCGTGCACGGCGTGCCGATGCTGCCGTTCTACATCTACTACT
CGATGTTCGGCTTCCAGCGCGTGGGCGACCTGATCTGGGCCGCGGCCGACCAGCGCGCGCGCGGCTTCCTGCTCGGCGCC
ACCGCGGGCCGCACCACGCTGGGCGGCGAGGGCCTGCAGCACCAGGACGGCTCCAGCCCACTGCAGGCGTCGACCGTGCC
CAACTGCCGCACCTGGGACCCGGCCTTCGCGGGCGAGGTGGCGGTGATCGTGGAGCACGGCATGCGCCGCATGCTCGAGG
AGCAGGCCGACGAGTTCTTCTACCTGCTGCTGATGAACGAGAACTACGCCAACCCCTCGCTGCCCGAGGGTGCGGCGGCC
GGCGTGCTGAAAGGCCTGTACCGCTTCCGGCCGGCGCAGGGCAGGAAGGCCGCGCAGGTGCGCCTGCTCGGCTCCGGCGC
GATCCTGCGCGAGGTGCTGGCCGCGGCCGAGCTGCTGCGCAACGACTACGGCGTGGAGGCCGAGGTGTGGAGCGCCACCA
GCTACAGCGAGCTGCAGCGCGAGGCCATCGAGGTGGAGCGCCACAACCGCCTGCAGCCGCAGGCGCCGCGCCGCCGCAGC
CACGTGGCGCAGTGCCTGGCCGGCAAGGCGCCGGTGGTGGCCGCGAGCGACTACGTGCGCGCCTGGCCGCAGCTGATCGC
ACCCTACGCCGAAGCCTCGCGCTTCGTGGCGCTGGGCACCGACGGCTTCGGCCGCAGCGACACGCGCGAGCAGCTGCGCC
GCCACTTCGAGGTGGACCGCGCGCACATCGCGCTGGCGGCGCTGGATGCGCTGGCGGACGCGGGGAGCGTGCCGCGGGAG
GTGGCGGTGAAGGCAGCGGGGCGGTTGGCGGGCTGA

Upstream 100 bases:

>100_bases
AGTCGCAGCACTTTATGCGGTAAATCGGGCCGCCGGCACCGTCTTTCGGTGGCATCTGCGGCCTCCGCAGGCGCACAGTG
CAGGGCAGAGGAGCCTTGCC

Downstream 100 bases:

>100_bases
AGCGCGTCCCGCGGCGGCGCGGGATTCATCTCAACCGAGCAAGCGCCTGAGCCACGCCACCAAGCGCGCCCAGACCCCCT
GGGCCGGCGCCTCGGTCGCT

Product: 2-oxoacid dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 891; Mature: 890

Protein sequence:

>891_residues
MTQVFEPLLFQAAAADTDPAETAEWRDALAAVLAAAGPERARFLLDQLAAQASEPAIAWQPRGGGSPYVNTIPVERQPRF
PGDLAIEERLASLMRWNALAMVVRANQAYGELGGHIASYASAADLFEVGFNHFFRARNAQQGGDLVFYQPHSAPGVYARA
FLEGRLSEADLAHYRQELAAPAAGAQGLSSYPHPWLMPEFWQFPTGSMGIGPISSIYQARFMRYLQHRGLLQTEGRRVWG
VFGDGEMDEPESMSALTLAAREKLDNLTWVINCNLQRLDGPVRGNGRIIDELEALFAGAGWQVIKLVWGSDWDGLFARDT
HGALRKAFAGTVDGQFQTFAAKDGRYNREHFFGQTPELAALAQGLTDEQIDRLRRGGHDMVKIHAAYHAAMQCRGRPVVI
LAQTKKGYGMGEAGQGRMTTHQQKKLDRDDLIAFRNRFALPLSDEQAASLAFYKPADDSPEMRYLHARRAALGGQIPARV
AQAPQLAVPPVARWGDFALNADGKEMSTTMAFVRMLTALLKDAQLGPRIVPIVADEARTFGMANLFKQIGIYSNLGQNYE
PEDIGSVLSYREATDGQILEEGISEAGALSSWVAAATSYSVHGVPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGA
TAGRTTLGGEGLQHQDGSSPLQASTVPNCRTWDPAFAGEVAVIVEHGMRRMLEEQADEFFYLLLMNENYANPSLPEGAAA
GVLKGLYRFRPAQGRKAAQVRLLGSGAILREVLAAAELLRNDYGVEAEVWSATSYSELQREAIEVERHNRLQPQAPRRRS
HVAQCLAGKAPVVAASDYVRAWPQLIAPYAEASRFVALGTDGFGRSDTREQLRRHFEVDRAHIALAALDALADAGSVPRE
VAVKAAGRLAG

Sequences:

>Translated_891_residues
MTQVFEPLLFQAAAADTDPAETAEWRDALAAVLAAAGPERARFLLDQLAAQASEPAIAWQPRGGGSPYVNTIPVERQPRF
PGDLAIEERLASLMRWNALAMVVRANQAYGELGGHIASYASAADLFEVGFNHFFRARNAQQGGDLVFYQPHSAPGVYARA
FLEGRLSEADLAHYRQELAAPAAGAQGLSSYPHPWLMPEFWQFPTGSMGIGPISSIYQARFMRYLQHRGLLQTEGRRVWG
VFGDGEMDEPESMSALTLAAREKLDNLTWVINCNLQRLDGPVRGNGRIIDELEALFAGAGWQVIKLVWGSDWDGLFARDT
HGALRKAFAGTVDGQFQTFAAKDGRYNREHFFGQTPELAALAQGLTDEQIDRLRRGGHDMVKIHAAYHAAMQCRGRPVVI
LAQTKKGYGMGEAGQGRMTTHQQKKLDRDDLIAFRNRFALPLSDEQAASLAFYKPADDSPEMRYLHARRAALGGQIPARV
AQAPQLAVPPVARWGDFALNADGKEMSTTMAFVRMLTALLKDAQLGPRIVPIVADEARTFGMANLFKQIGIYSNLGQNYE
PEDIGSVLSYREATDGQILEEGISEAGALSSWVAAATSYSVHGVPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGA
TAGRTTLGGEGLQHQDGSSPLQASTVPNCRTWDPAFAGEVAVIVEHGMRRMLEEQADEFFYLLLMNENYANPSLPEGAAA
GVLKGLYRFRPAQGRKAAQVRLLGSGAILREVLAAAELLRNDYGVEAEVWSATSYSELQREAIEVERHNRLQPQAPRRRS
HVAQCLAGKAPVVAASDYVRAWPQLIAPYAEASRFVALGTDGFGRSDTREQLRRHFEVDRAHIALAALDALADAGSVPRE
VAVKAAGRLAG
>Mature_890_residues
TQVFEPLLFQAAAADTDPAETAEWRDALAAVLAAAGPERARFLLDQLAAQASEPAIAWQPRGGGSPYVNTIPVERQPRFP
GDLAIEERLASLMRWNALAMVVRANQAYGELGGHIASYASAADLFEVGFNHFFRARNAQQGGDLVFYQPHSAPGVYARAF
LEGRLSEADLAHYRQELAAPAAGAQGLSSYPHPWLMPEFWQFPTGSMGIGPISSIYQARFMRYLQHRGLLQTEGRRVWGV
FGDGEMDEPESMSALTLAAREKLDNLTWVINCNLQRLDGPVRGNGRIIDELEALFAGAGWQVIKLVWGSDWDGLFARDTH
GALRKAFAGTVDGQFQTFAAKDGRYNREHFFGQTPELAALAQGLTDEQIDRLRRGGHDMVKIHAAYHAAMQCRGRPVVIL
AQTKKGYGMGEAGQGRMTTHQQKKLDRDDLIAFRNRFALPLSDEQAASLAFYKPADDSPEMRYLHARRAALGGQIPARVA
QAPQLAVPPVARWGDFALNADGKEMSTTMAFVRMLTALLKDAQLGPRIVPIVADEARTFGMANLFKQIGIYSNLGQNYEP
EDIGSVLSYREATDGQILEEGISEAGALSSWVAAATSYSVHGVPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGAT
AGRTTLGGEGLQHQDGSSPLQASTVPNCRTWDPAFAGEVAVIVEHGMRRMLEEQADEFFYLLLMNENYANPSLPEGAAAG
VLKGLYRFRPAQGRKAAQVRLLGSGAILREVLAAAELLRNDYGVEAEVWSATSYSELQREAIEVERHNRLQPQAPRRRSH
VAQCLAGKAPVVAASDYVRAWPQLIAPYAEASRFVALGTDGFGRSDTREQLRRHFEVDRAHIALAALDALADAGSVPREV
AVKAAGRLAG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=876, Percent_Identity=53.4246575342466, Blast_Score=961, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 97499; Mature: 97368

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVFEPLLFQAAAADTDPAETAEWRDALAAVLAAAGPERARFLLDQLAAQASEPAIAWQ
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEC
PRGGGSPYVNTIPVERQPRFPGDLAIEERLASLMRWNALAMVVRANQAYGELGGHIASYA
CCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHH
SAADLFEVGFNHFFRARNAQQGGDLVFYQPHSAPGVYARAFLEGRLSEADLAHYRQELAA
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
PAAGAQGLSSYPHPWLMPEFWQFPTGSMGIGPISSIYQARFMRYLQHRGLLQTEGRRVWG
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCEEEE
VFGDGEMDEPESMSALTLAAREKLDNLTWVINCNLQRLDGPVRGNGRIIDELEALFAGAG
EECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCCHHHHHHHHHCCCC
WQVIKLVWGSDWDGLFARDTHGALRKAFAGTVDGQFQTFAAKDGRYNREHFFGQTPELAA
CEEEEEEECCCCCCCEECCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCHHHH
LAQGLTDEQIDRLRRGGHDMVKIHAAYHAAMQCRGRPVVILAQTKKGYGMGEAGQGRMTT
HHCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
HQQKKLDRDDLIAFRNRFALPLSDEQAASLAFYKPADDSPEMRYLHARRAALGGQIPARV
HHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHH
AQAPQLAVPPVARWGDFALNADGKEMSTTMAFVRMLTALLKDAQLGPRIVPIVADEARTF
HCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
GMANLFKQIGIYSNLGQNYEPEDIGSVLSYREATDGQILEEGISEAGALSSWVAAATSYS
HHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
VHGVPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDGSSP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
LQASTVPNCRTWDPAFAGEVAVIVEHGMRRMLEEQADEFFYLLLMNENYANPSLPEGAAA
CCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHH
GVLKGLYRFRPAQGRKAAQVRLLGSGAILREVLAAAELLRNDYGVEAEVWSATSYSELQR
HHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
EAIEVERHNRLQPQAPRRRSHVAQCLAGKAPVVAASDYVRAWPQLIAPYAEASRFVALGT
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCEEEECC
DGFGRSDTREQLRRHFEVDRAHIALAALDALADAGSVPREVAVKAAGRLAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TQVFEPLLFQAAAADTDPAETAEWRDALAAVLAAAGPERARFLLDQLAAQASEPAIAWQ
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEC
PRGGGSPYVNTIPVERQPRFPGDLAIEERLASLMRWNALAMVVRANQAYGELGGHIASYA
CCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHH
SAADLFEVGFNHFFRARNAQQGGDLVFYQPHSAPGVYARAFLEGRLSEADLAHYRQELAA
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
PAAGAQGLSSYPHPWLMPEFWQFPTGSMGIGPISSIYQARFMRYLQHRGLLQTEGRRVWG
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCEEEE
VFGDGEMDEPESMSALTLAAREKLDNLTWVINCNLQRLDGPVRGNGRIIDELEALFAGAG
EECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCCHHHHHHHHHCCCC
WQVIKLVWGSDWDGLFARDTHGALRKAFAGTVDGQFQTFAAKDGRYNREHFFGQTPELAA
CEEEEEEECCCCCCCEECCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCHHHH
LAQGLTDEQIDRLRRGGHDMVKIHAAYHAAMQCRGRPVVILAQTKKGYGMGEAGQGRMTT
HHCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
HQQKKLDRDDLIAFRNRFALPLSDEQAASLAFYKPADDSPEMRYLHARRAALGGQIPARV
HHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHH
AQAPQLAVPPVARWGDFALNADGKEMSTTMAFVRMLTALLKDAQLGPRIVPIVADEARTF
HCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
GMANLFKQIGIYSNLGQNYEPEDIGSVLSYREATDGQILEEGISEAGALSSWVAAATSYS
HHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
VHGVPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDGSSP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
LQASTVPNCRTWDPAFAGEVAVIVEHGMRRMLEEQADEFFYLLLMNENYANPSLPEGAAA
CCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHH
GVLKGLYRFRPAQGRKAAQVRLLGSGAILREVLAAAELLRNDYGVEAEVWSATSYSELQR
HHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
EAIEVERHNRLQPQAPRRRSHVAQCLAGKAPVVAASDYVRAWPQLIAPYAEASRFVALGT
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCEEEECC
DGFGRSDTREQLRRHFEVDRAHIALAALDALADAGSVPREVAVKAAGRLAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]