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The map label for this gene is hmgA [H]

Identifier: 124266069

GI number: 124266069

Start: 916066

End: 917397

Strand: Direct

Name: hmgA [H]

Synonym: Mpe_A0876

Alternate gene names: 124266069

Gene position: 916066-917397 (Clockwise)

Preceding gene: 124266067

Following gene: 124266071

Centisome position: 22.65

GC content: 71.77

Gene sequence:

>1332_bases
ATGCTCGGCGAGGACGGGACTTCGATGCACCACGCTCCCCTGCGCTACCAGAGCGGCTTCGCCAACCACTTCGAGAGCGA
GGCGCTGCCCGGTGCGCTGCCGGTGGGCCGCAACTCGCCGCAGCGCTGCCCCTACGGTCTGTACGCCGAGCAGTTCAGCG
CCACCGCCTTCACCGCGCCGCGCGCCGACAACCGCCGCAGCTGGCTCTACCGCATCCGCCCGGCCGCGATGCACGCACCG
TTCGAGCCGTACGACGACGGCGGCCGGTTGGTCAGCGACTTCTCCACGCTCGCCACGCCGCCCGATCCGCTGCGCTGGAA
CCCGTTGCCGCTGCCGGCGGCGCCGACCGACTTCGTCGACGGCCTCGTGACCTGGGCCGGCCACGGCGATGCGGGCGTGC
AGGCCGGCGCCGCGGTCCATCTCTATGCCGCCGACCGCTCGATGGAGCAGCGCAGCTTCTGCAGTGCCGACGGCGAGCTG
CTGATCGTGCCCCAGCTCGGCCGCCACCGCTTCGTCACCGAGCTCGGCGTGCTGGAGGTCGAGCCGCAGGAGATCGTCGT
CATCCCGCGCGGCCTGCGCTTTCGCGTCGAGCTGCCCGACGGCGCGGGCCGCGGCTACGTGTGCGAGAACCACGGCGCGC
CGTTTCGCCTGCCCGACCTGGGGCCGATCGGCGCCAACGGCCTGGCGCATGCGCGCGACTTCCTCGCGCCGGTGGCGGCC
TACGAGGACATCGACGGGCCGCACCAGCTGGTCACCAAGTTCATGGGCCGGCTGTGGTCGGCGGCGATGGATCACTCGCC
GCTCGACGTGGTGGCCTGGCACGGCAACTGCGCACCGTACAAGTACGACCTGCGGCGCTTCAATGCCATCGGCTCGATCA
GCCACGACCACCCCGATCCGTCGATCTTCCTGGTGCTGCATGCGGCCTCCGACACGCCGGGCACCAGCGCCATCGACTTC
GTGGTCTTCCCGCCGCGCATCCTGGCGATGCAGGACACCTTCCGGCCGCCCTGGTTCCACCGCAACGTCGCCAGCGAGTT
CATGGGCCTGATCCACGGCGTGTACGACGCCAAGGCCGAAGGCTTCCTGCCCGGCGGCGCGAGCCTGCACAACTGCATGA
CCGGCCACGGCCCCGACGCCGAGACCTTCGAGAAGGCGAGCCGTGCCGACCTGTCGCAGCCCGACGTGATCCGCGACACC
ATGGCCTTCATGTTCGAGGCGCGCCACGTCTGGCGCCCGACACCCCGGGCGCTGGCCTCGCCGCTGCGGCAGGCCGACTA
CGCGCGCTGCTGGCAGGGCCTGCGCCGGCACTTCGATCCCGCACGGCGCTGA

Upstream 100 bases:

>100_bases
AGCAGCGTGGTGTGGGGCCCGGTGGACTCCAGCCGCACCGTGGCCCGGCCCTTGCCGTGGCCGGCGGTCCACCCGCAGCG
GCCGCAGGGCCGCAGGCAGA

Downstream 100 bases:

>100_bases
GCGCGCCGCGCGGGCCGCAGCTTCATCGGTCCCGGGCCTTCGCAGCGGCCTGCGCGGCCGCCTCGTCGTCTCTCAGCTGA
CGCGCGCGATCGACCACATA

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MLGEDGTSMHHAPLRYQSGFANHFESEALPGALPVGRNSPQRCPYGLYAEQFSATAFTAPRADNRRSWLYRIRPAAMHAP
FEPYDDGGRLVSDFSTLATPPDPLRWNPLPLPAAPTDFVDGLVTWAGHGDAGVQAGAAVHLYAADRSMEQRSFCSADGEL
LIVPQLGRHRFVTELGVLEVEPQEIVVIPRGLRFRVELPDGAGRGYVCENHGAPFRLPDLGPIGANGLAHARDFLAPVAA
YEDIDGPHQLVTKFMGRLWSAAMDHSPLDVVAWHGNCAPYKYDLRRFNAIGSISHDHPDPSIFLVLHAASDTPGTSAIDF
VVFPPRILAMQDTFRPPWFHRNVASEFMGLIHGVYDAKAEGFLPGGASLHNCMTGHGPDAETFEKASRADLSQPDVIRDT
MAFMFEARHVWRPTPRALASPLRQADYARCWQGLRRHFDPARR

Sequences:

>Translated_443_residues
MLGEDGTSMHHAPLRYQSGFANHFESEALPGALPVGRNSPQRCPYGLYAEQFSATAFTAPRADNRRSWLYRIRPAAMHAP
FEPYDDGGRLVSDFSTLATPPDPLRWNPLPLPAAPTDFVDGLVTWAGHGDAGVQAGAAVHLYAADRSMEQRSFCSADGEL
LIVPQLGRHRFVTELGVLEVEPQEIVVIPRGLRFRVELPDGAGRGYVCENHGAPFRLPDLGPIGANGLAHARDFLAPVAA
YEDIDGPHQLVTKFMGRLWSAAMDHSPLDVVAWHGNCAPYKYDLRRFNAIGSISHDHPDPSIFLVLHAASDTPGTSAIDF
VVFPPRILAMQDTFRPPWFHRNVASEFMGLIHGVYDAKAEGFLPGGASLHNCMTGHGPDAETFEKASRADLSQPDVIRDT
MAFMFEARHVWRPTPRALASPLRQADYARCWQGLRRHFDPARR
>Mature_443_residues
MLGEDGTSMHHAPLRYQSGFANHFESEALPGALPVGRNSPQRCPYGLYAEQFSATAFTAPRADNRRSWLYRIRPAAMHAP
FEPYDDGGRLVSDFSTLATPPDPLRWNPLPLPAAPTDFVDGLVTWAGHGDAGVQAGAAVHLYAADRSMEQRSFCSADGEL
LIVPQLGRHRFVTELGVLEVEPQEIVVIPRGLRFRVELPDGAGRGYVCENHGAPFRLPDLGPIGANGLAHARDFLAPVAA
YEDIDGPHQLVTKFMGRLWSAAMDHSPLDVVAWHGNCAPYKYDLRRFNAIGSISHDHPDPSIFLVLHAASDTPGTSAIDF
VVFPPRILAMQDTFRPPWFHRNVASEFMGLIHGVYDAKAEGFLPGGASLHNCMTGHGPDAETFEKASRADLSQPDVIRDT
MAFMFEARHVWRPTPRALASPLRQADYARCWQGLRRHFDPARR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=440, Percent_Identity=50.4545454545455, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17507969, Length=429, Percent_Identity=51.0489510489511, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24583650, Length=436, Percent_Identity=48.6238532110092, Blast_Score=406, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 48880; Mature: 48880

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGEDGTSMHHAPLRYQSGFANHFESEALPGALPVGRNSPQRCPYGLYAEQFSATAFTAP
CCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECC
RADNRRSWLYRIRPAAMHAPFEPYDDGGRLVSDFSTLATPPDPLRWNPLPLPAAPTDFVD
CCCCCCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
GLVTWAGHGDAGVQAGAAVHLYAADRSMEQRSFCSADGELLIVPQLGRHRFVTELGVLEV
HHHEECCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCCHHHHHHCCCEEE
EPQEIVVIPRGLRFRVELPDGAGRGYVCENHGAPFRLPDLGPIGANGLAHARDFLAPVAA
CCCEEEEECCCCEEEEECCCCCCCCCEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
YEDIDGPHQLVTKFMGRLWSAAMDHSPLDVVAWHGNCAPYKYDLRRFNAIGSISHDHPDP
HHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
SIFLVLHAASDTPGTSAIDFVVFPPRILAMQDTFRPPWFHRNVASEFMGLIHGVYDAKAE
EEEEEEEECCCCCCCCEEEEEEECCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GFLPGGASLHNCMTGHGPDAETFEKASRADLSQPDVIRDTMAFMFEARHVWRPTPRALAS
CCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
PLRQADYARCWQGLRRHFDPARR
HHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLGEDGTSMHHAPLRYQSGFANHFESEALPGALPVGRNSPQRCPYGLYAEQFSATAFTAP
CCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECC
RADNRRSWLYRIRPAAMHAPFEPYDDGGRLVSDFSTLATPPDPLRWNPLPLPAAPTDFVD
CCCCCCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
GLVTWAGHGDAGVQAGAAVHLYAADRSMEQRSFCSADGELLIVPQLGRHRFVTELGVLEV
HHHEECCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCCHHHHHHCCCEEE
EPQEIVVIPRGLRFRVELPDGAGRGYVCENHGAPFRLPDLGPIGANGLAHARDFLAPVAA
CCCEEEEECCCCEEEEECCCCCCCCCEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
YEDIDGPHQLVTKFMGRLWSAAMDHSPLDVVAWHGNCAPYKYDLRRFNAIGSISHDHPDP
HHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
SIFLVLHAASDTPGTSAIDFVVFPPRILAMQDTFRPPWFHRNVASEFMGLIHGVYDAKAE
EEEEEEEECCCCCCCCEEEEEEECCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GFLPGGASLHNCMTGHGPDAETFEKASRADLSQPDVIRDTMAFMFEARHVWRPTPRALAS
CCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
PLRQADYARCWQGLRRHFDPARR
HHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA