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The map label for this gene is hisB

Identifier: 124266026

GI number: 124266026

Start: 873540

End: 874139

Strand: Direct

Name: hisB

Synonym: Mpe_A0833

Alternate gene names: 124266026

Gene position: 873540-874139 (Clockwise)

Preceding gene: 124266025

Following gene: 124266027

Centisome position: 21.6

GC content: 68.33

Gene sequence:

>600_bases
ATGACCGAACCGAACCGTGTTGCCGAAGTCCGGCGCGACACCGCCGAAACGAAGATCCGCGTGCGCGTCGACCTCGACGG
CACGGGCGTGGCCAGGCTCGCCACCGGCATCGGCTTCTTCGACCACATGCTCGACCAGCTGGCGCGCCACGGGCTGGTCG
ACCTGGAGATCGAGGCCGACGGCGACCTGCACATCGACGGTCACCACACCGTCGAGGACGTTGGCATCACGCTCGGTCAG
GCCTTCGCCAAGGCGGTCGGCGACAAGAAGGGGCTGCGTCGCTACGGCCATGCCTACGTGCCGCTCGACGAGGCGCTGAG
CCGCGTGGTGGTCGACTTCTCCGGCCGGCCCGGGCTGCACATGCGCGTGCCGTTCAAGGCCGGCATGATCGGCGCGCTCG
ACACCCAGCTGGTCTACGAGTTCTTCCAGGGCTTCGTGAACCATGCCGGCGTCACGCTGCACATCGACAACCTGCACGGC
GACAACGCCCACCACCAGTGCGAGACGGTCTTCAAGGCCTTCGCCCGAGCGCTGCGCATGGCGCTGGAGCGCGACCCGCG
CATGGCCGGCGTCATCCCTTCCACCAAGGGCAGCCTCTGA

Upstream 100 bases:

>100_bases
TGTCCGGCCTGCACCCGCTGCTGGCAAACTGCCTGCGCCTCACCGTCGGCCTGCCCGAAGAGAACGACCAGATGATCGCG
GCCCTGAAAGGCATCCTGTC

Downstream 100 bases:

>100_bases
CATGAGCCGTCGCGTGGCGGTCATCGACTACGGCATGGGCAACCTGCGCTCGGTGTCGCAGGCCGTGCTGCACGCGGCCG
CCGGGACCGGCTTCGAGGTG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTEPNRVAEVRRDTAETKIRVRVDLDGTGVARLATGIGFFDHMLDQLARHGLVDLEIEADGDLHIDGHHTVEDVGITLGQ
AFAKAVGDKKGLRRYGHAYVPLDEALSRVVVDFSGRPGLHMRVPFKAGMIGALDTQLVYEFFQGFVNHAGVTLHIDNLHG
DNAHHQCETVFKAFARALRMALERDPRMAGVIPSTKGSL

Sequences:

>Translated_199_residues
MTEPNRVAEVRRDTAETKIRVRVDLDGTGVARLATGIGFFDHMLDQLARHGLVDLEIEADGDLHIDGHHTVEDVGITLGQ
AFAKAVGDKKGLRRYGHAYVPLDEALSRVVVDFSGRPGLHMRVPFKAGMIGALDTQLVYEFFQGFVNHAGVTLHIDNLHG
DNAHHQCETVFKAFARALRMALERDPRMAGVIPSTKGSL
>Mature_198_residues
TEPNRVAEVRRDTAETKIRVRVDLDGTGVARLATGIGFFDHMLDQLARHGLVDLEIEADGDLHIDGHHTVEDVGITLGQA
FAKAVGDKKGLRRYGHAYVPLDEALSRVVVDFSGRPGLHMRVPFKAGMIGALDTQLVYEFFQGFVNHAGVTLHIDNLHGD
NAHHQCETVFKAFARALRMALERDPRMAGVIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=200, Percent_Identity=47, Blast_Score=177, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=223, Percent_Identity=41.2556053811659, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_METPP (A2SE06)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001020030.1
- ProteinModelPortal:   A2SE06
- SMR:   A2SE06
- STRING:   A2SE06
- GeneID:   4786968
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0833
- NMPDR:   fig|279263.3.peg.2042
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   A2SE06
- BioCyc:   MPET420662:MPE_A0833-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21858; Mature: 21727

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPNRVAEVRRDTAETKIRVRVDLDGTGVARLATGIGFFDHMLDQLARHGLVDLEIEAD
CCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GDLHIDGHHTVEDVGITLGQAFAKAVGDKKGLRRYGHAYVPLDEALSRVVVDFSGRPGLH
CCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCE
MRVPFKAGMIGALDTQLVYEFFQGFVNHAGVTLHIDNLHGDNAHHQCETVFKAFARALRM
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ALERDPRMAGVIPSTKGSL
HHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEPNRVAEVRRDTAETKIRVRVDLDGTGVARLATGIGFFDHMLDQLARHGLVDLEIEAD
CCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GDLHIDGHHTVEDVGITLGQAFAKAVGDKKGLRRYGHAYVPLDEALSRVVVDFSGRPGLH
CCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCE
MRVPFKAGMIGALDTQLVYEFFQGFVNHAGVTLHIDNLHGDNAHHQCETVFKAFARALRM
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ALERDPRMAGVIPSTKGSL
HHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA