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The map label for this gene is hisC

Identifier: 124266025

GI number: 124266025

Start: 872428

End: 873543

Strand: Direct

Name: hisC

Synonym: Mpe_A0832

Alternate gene names: 124266025

Gene position: 872428-873543 (Clockwise)

Preceding gene: 124266024

Following gene: 124266026

Centisome position: 21.57

GC content: 71.59

Gene sequence:

>1116_bases
ATGAGCAGCAGCAACAGCAACAACGGCGGACCCCCGCTCGCGCCCCGCCTCGCGCGCTTCGTCCGCCAGGACGTGCAGAA
CATGCACGCCTACGCGATCCAGCCGTCGGACGGCTTCGTGAAGCTCGACGCGATGGAGAACCCGCACCGCCTGCCCGCCG
CGTTGCAGGCCGAGCTGGGCCGCCGGCTCGGCGCGCTGGCGATCAACCGCTATCCCGGCACGCGCACCGACGAGCTGCGC
GCGGCGCTGGCCCGCCACGCTGGCCTGCCGCCCGGTTGCGCGCTGATGCTGGGCAATGGCTCCGACGAGCTGATCTCGCT
GCTCAGCATGGCCTGCGATGTGCCGGGCGCCACCGTGCTGGCGCCGCTGCCGGGCTTCGTGATGTACGAGATGTCGGCCC
GGCTGCAGGGGCTGCGCTTCGTCGGCGTGCCGCTGACCGCCGACTTCGAGCTCGACGCCGCGGCGATGCTGGCCGCGGTG
CGCGAGCACCGGCCGGCCCTCACCTACCTGGCCTACCCGAACAACCCGACCGCCAACCTGTGGGACGACGCGGTGATCGA
GCGCGTCGTCGACGCGGTGCGCGAGCACGGCGGCCTGGTGGTGATCGACGAGGCCTACCAGCCCTTCGCGAGCCGCAGCT
ACATCGACCGGCTGGCGCACCACGACCACGTGCTGCTGATGCGCACGCTCAGCAAGTTCGGCCTGGCCGGTGTGCGGTTG
GGCTACCTGATGGGTCCGACCGCGCTGGTGGCCGAGATCGACAAGGTGCGCCCGCCCTACAACGTGAGCGTGCTGAACTG
CGAGGCGGCGCTGTTCGCGCTGGAGCACGAGGACGAGTTCGCGCGCCAGGCCGCCGTGCTGCGCGCCGAGCGCGCGCGGC
TGCTGGACGCGCTGCGCGCGATGTCGGGCGCCACGCCGTTCCCGAGCGAGGCCAACATGGTGCTGGTGCGGGTGCCCGAC
GCGAAGGCCGCCTTCGAGGGCCTGAAGGCGCGCGGCGTGCTGGTGAAGAACGTGTCCGGCCTGCACCCGCTGCTGGCAAA
CTGCCTGCGCCTCACCGTCGGCCTGCCCGAAGAGAACGACCAGATGATCGCGGCCCTGAAAGGCATCCTGTCATGA

Upstream 100 bases:

>100_bases
CGCTGGGCGTGATCGCCGCCGAGCTGGCCTACGGCGAGGGCCTGCAGGCGCACGCGCAGGCGGCCGAGATGCGGCTGGCG
AAGAAGCCGAGAGCGGCACG

Downstream 100 bases:

>100_bases
CCGAACCGAACCGTGTTGCCGAAGTCCGGCGCGACACCGCCGAAACGAAGATCCGCGTGCGCGTCGACCTCGACGGCACG
GGCGTGGCCAGGCTCGCCAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSSSNSNNGGPPLAPRLARFVRQDVQNMHAYAIQPSDGFVKLDAMENPHRLPAALQAELGRRLGALAINRYPGTRTDELR
AALARHAGLPPGCALMLGNGSDELISLLSMACDVPGATVLAPLPGFVMYEMSARLQGLRFVGVPLTADFELDAAAMLAAV
REHRPALTYLAYPNNPTANLWDDAVIERVVDAVREHGGLVVIDEAYQPFASRSYIDRLAHHDHVLLMRTLSKFGLAGVRL
GYLMGPTALVAEIDKVRPPYNVSVLNCEAALFALEHEDEFARQAAVLRAERARLLDALRAMSGATPFPSEANMVLVRVPD
AKAAFEGLKARGVLVKNVSGLHPLLANCLRLTVGLPEENDQMIAALKGILS

Sequences:

>Translated_371_residues
MSSSNSNNGGPPLAPRLARFVRQDVQNMHAYAIQPSDGFVKLDAMENPHRLPAALQAELGRRLGALAINRYPGTRTDELR
AALARHAGLPPGCALMLGNGSDELISLLSMACDVPGATVLAPLPGFVMYEMSARLQGLRFVGVPLTADFELDAAAMLAAV
REHRPALTYLAYPNNPTANLWDDAVIERVVDAVREHGGLVVIDEAYQPFASRSYIDRLAHHDHVLLMRTLSKFGLAGVRL
GYLMGPTALVAEIDKVRPPYNVSVLNCEAALFALEHEDEFARQAAVLRAERARLLDALRAMSGATPFPSEANMVLVRVPD
AKAAFEGLKARGVLVKNVSGLHPLLANCLRLTVGLPEENDQMIAALKGILS
>Mature_370_residues
SSSNSNNGGPPLAPRLARFVRQDVQNMHAYAIQPSDGFVKLDAMENPHRLPAALQAELGRRLGALAINRYPGTRTDELRA
ALARHAGLPPGCALMLGNGSDELISLLSMACDVPGATVLAPLPGFVMYEMSARLQGLRFVGVPLTADFELDAAAMLAAVR
EHRPALTYLAYPNNPTANLWDDAVIERVVDAVREHGGLVVIDEAYQPFASRSYIDRLAHHDHVLLMRTLSKFGLAGVRLG
YLMGPTALVAEIDKVRPPYNVSVLNCEAALFALEHEDEFARQAAVLRAERARLLDALRAMSGATPFPSEANMVLVRVPDA
KAAFEGLKARGVLVKNVSGLHPLLANCLRLTVGLPEENDQMIAALKGILS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=361, Percent_Identity=30.1939058171745, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788722, Length=319, Percent_Identity=24.7648902821317, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=385, Percent_Identity=29.8701298701299, Blast_Score=135, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METPP (A2SE05)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001020029.1
- ProteinModelPortal:   A2SE05
- SMR:   A2SE05
- STRING:   A2SE05
- GeneID:   4786967
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0832
- NMPDR:   fig|279263.3.peg.2043
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- PhylomeDB:   A2SE05
- ProtClustDB:   PRK04870
- BioCyc:   MPET420662:MPE_A0832-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40031; Mature: 39900

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSNSNNGGPPLAPRLARFVRQDVQNMHAYAIQPSDGFVKLDAMENPHRLPAALQAELG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHH
RRLGALAINRYPGTRTDELRAALARHAGLPPGCALMLGNGSDELISLLSMACDVPGATVL
HHHHHHEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEE
APLPGFVMYEMSARLQGLRFVGVPLTADFELDAAAMLAAVREHRPALTYLAYPNNPTANL
CCCCCHHHHHHHHHHCCCEEEECCEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
WDDAVIERVVDAVREHGGLVVIDEAYQPFASRSYIDRLAHHDHVLLMRTLSKFGLAGVRL
HHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHH
GYLMGPTALVAEIDKVRPPYNVSVLNCEAALFALEHEDEFARQAAVLRAERARLLDALRA
HHHHCHHHHHHHHHHCCCCCCEEEEEHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
MSGATPFPSEANMVLVRVPDAKAAFEGLKARGVLVKNVSGLHPLLANCLRLTVGLPEEND
HCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCCCH
QMIAALKGILS
HHHHHHHHHCC
>Mature Secondary Structure 
SSSNSNNGGPPLAPRLARFVRQDVQNMHAYAIQPSDGFVKLDAMENPHRLPAALQAELG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHH
RRLGALAINRYPGTRTDELRAALARHAGLPPGCALMLGNGSDELISLLSMACDVPGATVL
HHHHHHEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEE
APLPGFVMYEMSARLQGLRFVGVPLTADFELDAAAMLAAVREHRPALTYLAYPNNPTANL
CCCCCHHHHHHHHHHCCCEEEECCEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
WDDAVIERVVDAVREHGGLVVIDEAYQPFASRSYIDRLAHHDHVLLMRTLSKFGLAGVRL
HHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHH
GYLMGPTALVAEIDKVRPPYNVSVLNCEAALFALEHEDEFARQAAVLRAERARLLDALRA
HHHHCHHHHHHHHHHCCCCCCEEEEEHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
MSGATPFPSEANMVLVRVPDAKAAFEGLKARGVLVKNVSGLHPLLANCLRLTVGLPEEND
HCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCCCH
QMIAALKGILS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA