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The map label for this gene is rppH

Identifier: 124265709

GI number: 124265709

Start: 554443

End: 555042

Strand: Reverse

Name: rppH

Synonym: Mpe_A0516

Alternate gene names: 124265709

Gene position: 555042-554443 (Counterclockwise)

Preceding gene: 124265712

Following gene: 124265703

Centisome position: 13.72

GC content: 65.17

Gene sequence:

>600_bases
ATGCTCGACCGTGAAGGCTTCAGGCCCAACGTCGGCATCGTTCTGCTCAACCAGCGGAACCAGGTGTTCTGGGGCAAACG
CATACGCACCCACTCCTGGCAGTTTCCGCAAGGCGGCATCAAGTACGGTGAGACGCCCGAGCAGGCGATGTACCGTGAGC
TGCACGAAGAAGTGGGCTTGCAGCCCGAGCATGTGCGCATCCTGGCGCGCACGCGTGATTGGCTGCGCTATGAGGTGCCC
GACCATTACATCCGCCGCGAGGCCCGGGGCCACTACCGCGGCCAGAAGCAGATCTGGTTCTTGTTGCAGCTGACTGGCCG
CGACAACGACATGAACCTGCGTGCCTGCGACCACCCGGAGTTCGACGCGTGGCGCTGGAACGAGTACTGGGTACCGCTCG
AGGTGGTGATCGACTTCAAGCGAGACGTCTACCAGATGGCGCTGACCGAACTGGCGCGCTTCCTGCCACGCGCCAACCAC
CACAACCGCTACCTGCGCTCGGGCATGCGGGCGCACCGGCGGGAGGACGAAGAGCGCTCCAACGGCGAGGCGCCCATGGA
AGCCGCCGACGGTGAGACGACGCCCGAAGGTCCGCGCTGA

Upstream 100 bases:

>100_bases
GCGATGCCGCCAGGCCGACCCCGCAACCTGGGGCGGAGCGGGCTTGCATCGCGGAAGCCCGGTGCAATAATGAATTCAAG
ACTGAATTCGAGGTTTCATT

Downstream 100 bases:

>100_bases
GGCCCTGCGTCGGCGTCAGCGGTGCCGGCGGTTGAGCAGGCTCAGCCCCACAGCCACCGCCACGAGCGCCACCAGCAACT
CGACGCCCACCGGCTCCTCC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLDREGFRPNVGIVLLNQRNQVFWGKRIRTHSWQFPQGGIKYGETPEQAMYRELHEEVGLQPEHVRILARTRDWLRYEVP
DHYIRREARGHYRGQKQIWFLLQLTGRDNDMNLRACDHPEFDAWRWNEYWVPLEVVIDFKRDVYQMALTELARFLPRANH
HNRYLRSGMRAHRREDEERSNGEAPMEAADGETTPEGPR

Sequences:

>Translated_199_residues
MLDREGFRPNVGIVLLNQRNQVFWGKRIRTHSWQFPQGGIKYGETPEQAMYRELHEEVGLQPEHVRILARTRDWLRYEVP
DHYIRREARGHYRGQKQIWFLLQLTGRDNDMNLRACDHPEFDAWRWNEYWVPLEVVIDFKRDVYQMALTELARFLPRANH
HNRYLRSGMRAHRREDEERSNGEAPMEAADGETTPEGPR
>Mature_199_residues
MLDREGFRPNVGIVLLNQRNQVFWGKRIRTHSWQFPQGGIKYGETPEQAMYRELHEEVGLQPEHVRILARTRDWLRYEVP
DHYIRREARGHYRGQKQIWFLLQLTGRDNDMNLRACDHPEFDAWRWNEYWVPLEVVIDFKRDVYQMALTELARFLPRANH
HNRYLRSGMRAHRREDEERSNGEAPMEAADGETTPEGPR

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=155, Percent_Identity=54.1935483870968, Blast_Score=183, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_METPP (A2SD39)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019713.1
- ProteinModelPortal:   A2SD39
- SMR:   A2SD39
- STRING:   A2SD39
- GeneID:   4787092
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0516
- NMPDR:   fig|279263.3.peg.2760
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   A2SD39
- ProtClustDB:   PRK00714
- BioCyc:   MPET420662:MPE_A0516-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 23951; Mature: 23951

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDREGFRPNVGIVLLNQRNQVFWGKRIRTHSWQFPQGGIKYGETPEQAMYRELHEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
QPEHVRILARTRDWLRYEVPDHYIRREARGHYRGQKQIWFLLQLTGRDNDMNLRACDHPE
CHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEECCCCC
FDAWRWNEYWVPLEVVIDFKRDVYQMALTELARFLPRANHHNRYLRSGMRAHRREDEERS
CCCEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHC
NGEAPMEAADGETTPEGPR
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDREGFRPNVGIVLLNQRNQVFWGKRIRTHSWQFPQGGIKYGETPEQAMYRELHEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
QPEHVRILARTRDWLRYEVPDHYIRREARGHYRGQKQIWFLLQLTGRDNDMNLRACDHPE
CHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEECCCCC
FDAWRWNEYWVPLEVVIDFKRDVYQMALTELARFLPRANHHNRYLRSGMRAHRREDEERS
CCCEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHC
NGEAPMEAADGETTPEGPR
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA