Click here to switch to the map view.

The map label for this gene is uvrY [H]

Identifier: 124265550

GI number: 124265550

Start: 392100

End: 392732

Strand: Reverse

Name: uvrY [H]

Synonym: Mpe_A0357

Alternate gene names: 124265550

Gene position: 392732-392100 (Counterclockwise)

Preceding gene: 124265551

Following gene: 124265548

Centisome position: 9.71

GC content: 71.72

Gene sequence:

>633_bases
ATGACGATCCGCGTGATGCTGGTCGACGACCACGCGATCGTGCGCGAGGGCTACAAGCGCCTGCTGGAGCTGCAGAGCGA
CATCGTCGTGGTGGCCGAGGCGGGCGACGGCGGCGAGGCATTGAACCAGTGGCGCGCGCTGCGGCCGGCGGTGGTGGTGA
TCGACCTGGGCCTGCCGGGCATGGGGGGGCTGGAACTGATCGCCCGGCTGCGCCAGCGCGACGAGGCCTGCCGCATGCTC
GCCTTCAGCATGCACCGCGACGCGGTCTGGGTGGCGCAGGCGCTGCGCGCCGGCGCGCTGGGCTACGTGACCAAGAGCAG
CGCGCCCTCGCAGCTGGTGGCTGCGGTGCGCGAGGTGAATCAGGGCCGCCGCGTGCTGAGCCCGGATGTCTCGGGCGAGG
TGGCCAGCGCCCTGCTCGACCCGCAGGACAGCGCCGCGCACGGCCTGTCGCCGCGCGAGTTCGAGGTGATGCGGTTGCTG
GTGGGCGGCCGCACGCCGCAGGAGATCGCGCAGTCGCTGAGCCTGAGCGTGAAGACGGTGCACAACGTGCACTACCAGAT
CAAGTCCAAGCTCGGCACGGCCAGCGACTTCGAGCTCGCGCGCATGGCCTGGCAGCGCGGCTGGATCGGCTGA

Upstream 100 bases:

>100_bases
TCTCGGCACTGGGCGGCACGCTGGACGTGGCGCCCTGCCTGCCCGGCGGCATGCGGCTGGCAGTGACGCTGCCCTTGCCA
CCGCTGGAGGAGACGCTGGC

Downstream 100 bases:

>100_bases
GCGCCGCGGGCGCGCGCGCTCAGCCCGCGCGCGGGAAAAACGCCAGCGTCACGAGCAGCAGGGCCGCGTACATGCCGATC
TCGGCGGTCTCGGTCCAGGG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTIRVMLVDDHAIVREGYKRLLELQSDIVVVAEAGDGGEALNQWRALRPAVVVIDLGLPGMGGLELIARLRQRDEACRML
AFSMHRDAVWVAQALRAGALGYVTKSSAPSQLVAAVREVNQGRRVLSPDVSGEVASALLDPQDSAAHGLSPREFEVMRLL
VGGRTPQEIAQSLSLSVKTVHNVHYQIKSKLGTASDFELARMAWQRGWIG

Sequences:

>Translated_210_residues
MTIRVMLVDDHAIVREGYKRLLELQSDIVVVAEAGDGGEALNQWRALRPAVVVIDLGLPGMGGLELIARLRQRDEACRML
AFSMHRDAVWVAQALRAGALGYVTKSSAPSQLVAAVREVNQGRRVLSPDVSGEVASALLDPQDSAAHGLSPREFEVMRLL
VGGRTPQEIAQSLSLSVKTVHNVHYQIKSKLGTASDFELARMAWQRGWIG
>Mature_209_residues
TIRVMLVDDHAIVREGYKRLLELQSDIVVVAEAGDGGEALNQWRALRPAVVVIDLGLPGMGGLELIARLRQRDEACRMLA
FSMHRDAVWVAQALRAGALGYVTKSSAPSQLVAAVREVNQGRRVLSPDVSGEVASALLDPQDSAAHGLSPREFEVMRLLV
GGRTPQEIAQSLSLSVKTVHNVHYQIKSKLGTASDFELARMAWQRGWIG

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=207, Percent_Identity=35.2657004830918, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790102, Length=206, Percent_Identity=39.8058252427184, Blast_Score=128, Evalue=2e-31,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786747, Length=200, Percent_Identity=29.5, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=32.7868852459016, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1788521, Length=183, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=28.921568627451, Blast_Score=82, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22887; Mature: 22756

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2 ; PS00716 SIGMA70_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRVMLVDDHAIVREGYKRLLELQSDIVVVAEAGDGGEALNQWRALRPAVVVIDLGLPG
CEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCC
MGGLELIARLRQRDEACRMLAFSMHRDAVWVAQALRAGALGYVTKSSAPSQLVAAVREVN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHH
QGRRVLSPDVSGEVASALLDPQDSAAHGLSPREFEVMRLLVGGRTPQEIAQSLSLSVKTV
CCCEECCCCCCHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
HNVHYQIKSKLGTASDFELARMAWQRGWIG
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TIRVMLVDDHAIVREGYKRLLELQSDIVVVAEAGDGGEALNQWRALRPAVVVIDLGLPG
EEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCEEEEEECCCCC
MGGLELIARLRQRDEACRMLAFSMHRDAVWVAQALRAGALGYVTKSSAPSQLVAAVREVN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHH
QGRRVLSPDVSGEVASALLDPQDSAAHGLSPREFEVMRLLVGGRTPQEIAQSLSLSVKTV
CCCEECCCCCCHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
HNVHYQIKSKLGTASDFELARMAWQRGWIG
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]