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The map label for this gene is moxY [H]

Identifier: 124265551

GI number: 124265551

Start: 392729

End: 394195

Strand: Reverse

Name: moxY [H]

Synonym: Mpe_A0358

Alternate gene names: 124265551

Gene position: 394195-392729 (Counterclockwise)

Preceding gene: 124265552

Following gene: 124265550

Centisome position: 9.75

GC content: 74.57

Gene sequence:

>1467_bases
ATGCAAGATGCGCGGCACACCGTGCCGCCCATGTCCCTGCCCCCTTCCGTCCTTCCCGCGCCGCCGCTCGCCGCGCCCGG
CACCAACACCGGCGCGCGGCCGGTGCTGCACCTGCGGCGCGCGCTGATCTGGCGCATCGTATTGATCGCCGTGGCGGTGC
TGCTGTCGCTGGCCGCCTGGGAGGTGCGCGTGCTGCGCCAGGCGGCGACCGCCGAGCTGCCGGCCACCGCGTCGCTGGTG
GCGCAGCTGCTGAACGACGATCTGGCGCGACGCACCTCGTCGTTCGACCGCATCGACATCGAGGTGCCGCTGACGCCGCT
GGAGCGGCTGGGACGGCGCATCTCGTTCTGCGTCGAGGTCCAGCACCTGATGCGCGACCGGCCGCTGGCGCAGTCCTGCC
TGTCCGAGGAGCCGGTGACGGACGCCGGGCGCCTGCTGGCGCCGTGGCTGCGCGCCGGCGCGATCGGCAACGCCCAGGCC
ACGCGGCTGCTGCAGTTGCAGGCCGGCATCCGCGCCGGAACCATCGTGGTCACGCCGAACTGGGACAGCCTCGGCCAGAT
GCTGTGGCAGCGCTGGCTGGTGCTGGGCGGCTTCGCGCTCGGCTTCGTGGGGGTGGTGGCGGCGGTGGCGCTGCTGGTGG
ACCGCTCGCTGCGCCCGGCCAACGAGGTGCTGACGGCGCTGGCGCGGCTGGAGGGCGGCGACCTGAGCGTGCGGCTGCCG
CCGTTCGCGCTGAGCGAGCTGCGCAGCATCGCCGGCAGCTTCAACCGGCTGGCGGCGCGCTGGGCCGCCACCACGGCGCG
CCAGCGCCTGCTGACCGAGCGGCTGCTGCAGGTGCGCGAAGAGGAGCGCCGGCGCCTCGCGCGCGAGCTGCACGACGAGA
TGGGTCAGAGCCTGGCCGCGCTGTGGGCCGAGGCCGAGGTGGTGTCCACGCTGGCCGGCCAGTCGCTGCCGCAGCTGCGG
CCGAGCGCCGACGCGATGTCACGCACCACCGAGCACCTGCTCGAGGGCCTGCAGCGGGTGCTGTCGGACCTGCGGCCTCC
GGCGCTCGACCGCTTCGGGCTCGCACAGGCCCTGCAGGCGCTGGTGGCGCAGCCGCGGCGCCGGGCCGCGCAGGGCGACC
TGCACGCCACGCTGGAGATCGACGGCGACACCGAACGCATCCCGGACTCGATGCGGGTGCACGTCTACCGCATCGTGCAG
GAAGCGCTGACGAACGCGGTGCGCCACGGCGATGCCGCACAGGCGCGCGTTCGGCTCGCCTGCACCGAGCGGCAGGTGAG
CATCGAGGTGACCGACAACGGCAGCCACGTCGGCGTGGCGGTGCCGGTGCCGGGCCACGGTCTGCTGGGCATGAGCGAGC
GGGTCTCGGCACTGGGCGGCACGCTGGACGTGGCGCCCTGCCTGCCCGGCGGCATGCGGCTGGCAGTGACGCTGCCCTTG
CCACCGCTGGAGGAGACGCTGGCATGA

Upstream 100 bases:

>100_bases
GGGTGCCCGGGGGGCACCCCTTTTTTGTGGCGCGCCCGCCGGCGGCCCACGGGCAAACTGCCTTCCGCGACGCACCCGCC
CCGGGCCGGCCGCCTGCTTG

Downstream 100 bases:

>100_bases
CGATCCGCGTGATGCTGGTCGACGACCACGCGATCGTGCGCGAGGGCTACAAGCGCCTGCTGGAGCTGCAGAGCGACATC
GTCGTGGTGGCCGAGGCGGG

Product: two-component sensor histidine kinase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MQDARHTVPPMSLPPSVLPAPPLAAPGTNTGARPVLHLRRALIWRIVLIAVAVLLSLAAWEVRVLRQAATAELPATASLV
AQLLNDDLARRTSSFDRIDIEVPLTPLERLGRRISFCVEVQHLMRDRPLAQSCLSEEPVTDAGRLLAPWLRAGAIGNAQA
TRLLQLQAGIRAGTIVVTPNWDSLGQMLWQRWLVLGGFALGFVGVVAAVALLVDRSLRPANEVLTALARLEGGDLSVRLP
PFALSELRSIAGSFNRLAARWAATTARQRLLTERLLQVREEERRRLARELHDEMGQSLAALWAEAEVVSTLAGQSLPQLR
PSADAMSRTTEHLLEGLQRVLSDLRPPALDRFGLAQALQALVAQPRRRAAQGDLHATLEIDGDTERIPDSMRVHVYRIVQ
EALTNAVRHGDAAQARVRLACTERQVSIEVTDNGSHVGVAVPVPGHGLLGMSERVSALGGTLDVAPCLPGGMRLAVTLPL
PPLEETLA

Sequences:

>Translated_488_residues
MQDARHTVPPMSLPPSVLPAPPLAAPGTNTGARPVLHLRRALIWRIVLIAVAVLLSLAAWEVRVLRQAATAELPATASLV
AQLLNDDLARRTSSFDRIDIEVPLTPLERLGRRISFCVEVQHLMRDRPLAQSCLSEEPVTDAGRLLAPWLRAGAIGNAQA
TRLLQLQAGIRAGTIVVTPNWDSLGQMLWQRWLVLGGFALGFVGVVAAVALLVDRSLRPANEVLTALARLEGGDLSVRLP
PFALSELRSIAGSFNRLAARWAATTARQRLLTERLLQVREEERRRLARELHDEMGQSLAALWAEAEVVSTLAGQSLPQLR
PSADAMSRTTEHLLEGLQRVLSDLRPPALDRFGLAQALQALVAQPRRRAAQGDLHATLEIDGDTERIPDSMRVHVYRIVQ
EALTNAVRHGDAAQARVRLACTERQVSIEVTDNGSHVGVAVPVPGHGLLGMSERVSALGGTLDVAPCLPGGMRLAVTLPL
PPLEETLA
>Mature_488_residues
MQDARHTVPPMSLPPSVLPAPPLAAPGTNTGARPVLHLRRALIWRIVLIAVAVLLSLAAWEVRVLRQAATAELPATASLV
AQLLNDDLARRTSSFDRIDIEVPLTPLERLGRRISFCVEVQHLMRDRPLAQSCLSEEPVTDAGRLLAPWLRAGAIGNAQA
TRLLQLQAGIRAGTIVVTPNWDSLGQMLWQRWLVLGGFALGFVGVVAAVALLVDRSLRPANEVLTALARLEGGDLSVRLP
PFALSELRSIAGSFNRLAARWAATTARQRLLTERLLQVREEERRRLARELHDEMGQSLAALWAEAEVVSTLAGQSLPQLR
PSADAMSRTTEHLLEGLQRVLSDLRPPALDRFGLAQALQALVAQPRRRAAQGDLHATLEIDGDTERIPDSMRVHVYRIVQ
EALTNAVRHGDAAQARVRLACTERQVSIEVTDNGSHVGVAVPVPGHGLLGMSERVSALGGTLDVAPCLPGGMRLAVTLPL
PPLEETLA

Specific function: Member of the two-component regulatory system moxY/moxX probably involved in the regulation of the methanol dehydrogenase expression. May function as a membrane-associated protein kinase that phosphorylates moxX in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=215, Percent_Identity=34.8837209302326, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787474, Length=209, Percent_Identity=28.2296650717703, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788812, Length=215, Percent_Identity=28.8372093023256, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712 [H]

Pfam domain/function: PF00672 HAMP; PF07730 HisKA_3 [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 52843; Mature: 52843

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDARHTVPPMSLPPSVLPAPPLAAPGTNTGARPVLHLRRALIWRIVLIAVAVLLSLAAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVRVLRQAATAELPATASLVAQLLNDDLARRTSSFDRIDIEVPLTPLERLGRRISFCVEV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHH
QHLMRDRPLAQSCLSEEPVTDAGRLLAPWLRAGAIGNAQATRLLQLQAGIRAGTIVVTPN
HHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECC
WDSLGQMLWQRWLVLGGFALGFVGVVAAVALLVDRSLRPANEVLTALARLEGGDLSVRLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECC
PFALSELRSIAGSFNRLAARWAATTARQRLLTERLLQVREEERRRLARELHDEMGQSLAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWAEAEVVSTLAGQSLPQLRPSADAMSRTTEHLLEGLQRVLSDLRPPALDRFGLAQALQA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LVAQPRRRAAQGDLHATLEIDGDTERIPDSMRVHVYRIVQEALTNAVRHGDAAQARVRLA
HHHHHHHHHCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEE
CTERQVSIEVTDNGSHVGVAVPVPGHGLLGMSERVSALGGTLDVAPCLPGGMRLAVTLPL
EECCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCCEECCCCCCCCEEEEEECC
PPLEETLA
CCHHHHCC
>Mature Secondary Structure
MQDARHTVPPMSLPPSVLPAPPLAAPGTNTGARPVLHLRRALIWRIVLIAVAVLLSLAAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVRVLRQAATAELPATASLVAQLLNDDLARRTSSFDRIDIEVPLTPLERLGRRISFCVEV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHH
QHLMRDRPLAQSCLSEEPVTDAGRLLAPWLRAGAIGNAQATRLLQLQAGIRAGTIVVTPN
HHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECC
WDSLGQMLWQRWLVLGGFALGFVGVVAAVALLVDRSLRPANEVLTALARLEGGDLSVRLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECC
PFALSELRSIAGSFNRLAARWAATTARQRLLTERLLQVREEERRRLARELHDEMGQSLAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWAEAEVVSTLAGQSLPQLRPSADAMSRTTEHLLEGLQRVLSDLRPPALDRFGLAQALQA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LVAQPRRRAAQGDLHATLEIDGDTERIPDSMRVHVYRIVQEALTNAVRHGDAAQARVRLA
HHHHHHHHHCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEE
CTERQVSIEVTDNGSHVGVAVPVPGHGLLGMSERVSALGGTLDVAPCLPGGMRLAVTLPL
EECCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCCEECCCCCCCCEEEEEECC
PPLEETLA
CCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392137 [H]