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The map label for this gene is hemE

Identifier: 124265327

GI number: 124265327

Start: 139342

End: 140460

Strand: Reverse

Name: hemE

Synonym: Mpe_A0134

Alternate gene names: 124265327

Gene position: 140460-139342 (Counterclockwise)

Preceding gene: 124265331

Following gene: 124265326

Centisome position: 3.47

GC content: 71.58

Gene sequence:

>1119_bases
ATGACTGCCACCCCCACCGCCTCCCTGCCGCCGCTCGCGAACGACCGCTTCCTGCGCGCCTGCCTGCGCCTGCCCACCGA
CGTGACGCCGGTGTGGCTGATGCGCCAGGCCGGCCGCTACCTGAGCGAGTACCGCGACACGCGCGCCAAGGCGGGCAGCT
TCATGGGGCTGGCCACCAACCCGCAGTACGCCACCGAGGTGACGCTGCAGCCGCTGGACCGCTACCCGCTCGACGCGGCC
ATCCTGTTCAGCGACATCCTCACCGTGCCCGACGCCATGGGCCTGGGCCTGAGCTTCGCGCAGGGCGAGGGCCCGCGCTT
CGCGCACCCGCTGCGCGACGAGGCCGACGTGGCCAAGCTGCAGGTGCCCGACATGGAGAAGCTGCGCTACGTGTTCGACG
CGGTGGCGTCGATCCGGCGTGCGCTGGCGCCGGCCGGCGCGCCGGGGCGGGTGCCGCTGATCGGCTTCTCGGGCAGCCCG
TGGACGCTGGCTTGCTACATGGTCGAGGGTGCGGGCAGCGACGACTACCGCCTCGTCAAGACCCTGCTCTACCGCCGGCC
CGACCTGATGCACCGCATCCTCGAGGTGAACGCCGATGCGGTGGCGGCCTACCTGAACGCGCAGATCGAGGCCGGCGCGC
AGGCGGTGATGATCTTCGACAGCTGGGGCGGCGTGCTGGCCGACGGCGCCTTCCAGCGCTTCAGCCTGGCCTACACCGAG
CGCGTGCTGCGCCAATTGAAGAAGGAGCAAGGCGGTTATCGCGTGCCGCAGATCGTGTTCACCAAAGGCGGCGGGTTGTG
GCTGGAGGCCATTGCCGACAGCGGCTGCGACGTGGTGGGCCTGGACTGGACCATGAACCTCGGCGCGGCGCGCGCGCGCG
TCGGCGACCGCGTGGCCCTGCAGGGCAACCTGGACCCGAACGTGCTGTTCGCCGACCCGGAGCAGATCCGCGCCGAGGTG
GCGCGCACGCTGGACAGCTATGGCGCGCCGTCGGCCGGCAGCGGCCACGTGTTCAACCTCGGCCACGGCATCAGCCAGCA
CACGCCGCCCGACAGCGTGAGCGTGCTGGTGGATGCGGTGCATTCCTATTCACGGCAGCAGCGCGGCGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
CGTAGCTCAGCGTGTCGGCGATGCCGGGTTCGTCTTCGACGATCAGGATCTGCGCGCGGGCCATGGTCGGCGCCGATGAT
AGGGCCGCGATAATCGACCG

Downstream 100 bases:

>100_bases
CCCGGGGGTCGAGACGGCGCTGGGTGCATCCGGCAAGCCGGGTTTACCCGCAAACGACGCCCGAGAGGCCTGACTTATCC
CCAGAATCGTGTCAAGCCCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTATPTASLPPLANDRFLRACLRLPTDVTPVWLMRQAGRYLSEYRDTRAKAGSFMGLATNPQYATEVTLQPLDRYPLDAA
ILFSDILTVPDAMGLGLSFAQGEGPRFAHPLRDEADVAKLQVPDMEKLRYVFDAVASIRRALAPAGAPGRVPLIGFSGSP
WTLACYMVEGAGSDDYRLVKTLLYRRPDLMHRILEVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADGAFQRFSLAYTE
RVLRQLKKEQGGYRVPQIVFTKGGGLWLEAIADSGCDVVGLDWTMNLGAARARVGDRVALQGNLDPNVLFADPEQIRAEV
ARTLDSYGAPSAGSGHVFNLGHGISQHTPPDSVSVLVDAVHSYSRQQRGAAG

Sequences:

>Translated_372_residues
MTATPTASLPPLANDRFLRACLRLPTDVTPVWLMRQAGRYLSEYRDTRAKAGSFMGLATNPQYATEVTLQPLDRYPLDAA
ILFSDILTVPDAMGLGLSFAQGEGPRFAHPLRDEADVAKLQVPDMEKLRYVFDAVASIRRALAPAGAPGRVPLIGFSGSP
WTLACYMVEGAGSDDYRLVKTLLYRRPDLMHRILEVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADGAFQRFSLAYTE
RVLRQLKKEQGGYRVPQIVFTKGGGLWLEAIADSGCDVVGLDWTMNLGAARARVGDRVALQGNLDPNVLFADPEQIRAEV
ARTLDSYGAPSAGSGHVFNLGHGISQHTPPDSVSVLVDAVHSYSRQQRGAAG
>Mature_371_residues
TATPTASLPPLANDRFLRACLRLPTDVTPVWLMRQAGRYLSEYRDTRAKAGSFMGLATNPQYATEVTLQPLDRYPLDAAI
LFSDILTVPDAMGLGLSFAQGEGPRFAHPLRDEADVAKLQVPDMEKLRYVFDAVASIRRALAPAGAPGRVPLIGFSGSPW
TLACYMVEGAGSDDYRLVKTLLYRRPDLMHRILEVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADGAFQRFSLAYTER
VLRQLKKEQGGYRVPQIVFTKGGGLWLEAIADSGCDVVGLDWTMNLGAARARVGDRVALQGNLDPNVLFADPEQIRAEVA
RTLDSYGAPSAGSGHVFNLGHGISQHTPPDSVSVLVDAVHSYSRQQRGAAG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=365, Percent_Identity=47.3972602739726, Blast_Score=315, Evalue=6e-86,
Organism=Escherichia coli, GI2367337, Length=356, Percent_Identity=60.1123595505618, Blast_Score=427, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320252, Length=364, Percent_Identity=37.6373626373626, Blast_Score=249, Evalue=7e-67,
Organism=Drosophila melanogaster, GI19921920, Length=359, Percent_Identity=40.3899721448468, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI221330099, Length=359, Percent_Identity=40.3899721448468, Blast_Score=258, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_METPP (A2SC07)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019331.1
- ProteinModelPortal:   A2SC07
- SMR:   A2SC07
- STRING:   A2SC07
- GeneID:   4784834
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0134
- NMPDR:   fig|279263.3.peg.320
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   A2SC07
- BioCyc:   MPET420662:MPE_A0134-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 40233; Mature: 40102

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 85-85 BINDING 166-166 BINDING 221-221 BINDING 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATPTASLPPLANDRFLRACLRLPTDVTPVWLMRQAGRYLSEYRDTRAKAGSFMGLATN
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
PQYATEVTLQPLDRYPLDAAILFSDILTVPDAMGLGLSFAQGEGPRFAHPLRDEADVAKL
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCCCHHEE
QVPDMEKLRYVFDAVASIRRALAPAGAPGRVPLIGFSGSPWTLACYMVEGAGSDDYRLVK
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHH
TLLYRRPDLMHRILEVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADGAFQRFSLAYTE
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHHHHHHHHH
RVLRQLKKEQGGYRVPQIVFTKGGGLWLEAIADSGCDVVGLDWTMNLGAARARVGDRVAL
HHHHHHHHHCCCCCCCEEEEECCCCEEEEEHHCCCCCEEEECEEECCCHHHHHCCCEEEE
QGNLDPNVLFADPEQIRAEVARTLDSYGAPSAGSGHVFNLGHGISQHTPPDSVSVLVDAV
ECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHH
HSYSRQQRGAAG
HHHHHHHCCCCC
>Mature Secondary Structure 
TATPTASLPPLANDRFLRACLRLPTDVTPVWLMRQAGRYLSEYRDTRAKAGSFMGLATN
CCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
PQYATEVTLQPLDRYPLDAAILFSDILTVPDAMGLGLSFAQGEGPRFAHPLRDEADVAKL
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCCCHHEE
QVPDMEKLRYVFDAVASIRRALAPAGAPGRVPLIGFSGSPWTLACYMVEGAGSDDYRLVK
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHH
TLLYRRPDLMHRILEVNADAVAAYLNAQIEAGAQAVMIFDSWGGVLADGAFQRFSLAYTE
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHHHHHHHHH
RVLRQLKKEQGGYRVPQIVFTKGGGLWLEAIADSGCDVVGLDWTMNLGAARARVGDRVAL
HHHHHHHHHCCCCCCCEEEEECCCCEEEEEHHCCCCCEEEECEEECCCHHHHHCCCEEEE
QGNLDPNVLFADPEQIRAEVARTLDSYGAPSAGSGHVFNLGHGISQHTPPDSVSVLVDAV
ECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHH
HSYSRQQRGAAG
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA