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The map label for this gene is ndk

Identifier: 124024518

GI number: 124024518

Start: 2493620

End: 2494078

Strand: Reverse

Name: ndk

Synonym: P9303_28301

Alternate gene names: 124024518

Gene position: 2494078-2493620 (Counterclockwise)

Preceding gene: 124024520

Following gene: 124024516

Centisome position: 92.97

GC content: 54.47

Gene sequence:

>459_bases
ATGGCCGTAGAGCGCACCTTTGTTGCCATCAAGCCCGATGGTGTTCAGCGGGGTCTAGTGGGAGAAATTCTCGGTCGCTT
TGAGCGCAAGGGTTTCAAGCTCGTGGGGCTCAAACAGCTCGCCCCTAGCCGCGAGTTGGCTGGTGAGCATTACGGAGTGC
ACCGTGAGCGTCCTTTCTTTGCTGGGCTTGTTGATTTCATTACTTCCGGTCCAGTGGTTGCCATGGTTTGGGAAGGTGAT
GGAGTGATTGCTAGCGCTCGTAAGTTGATTGGCGCCACTAAGCCTCTGGAGGCTGAGCCTGGCACTATCCGTGGCGATTT
AGCTGTGAACATCGGCCGCAATGTGATTCACGGTTCGGATGGTCCAGACACGGCTCAGTTTGAGATCAATCTGTGGTTCT
CGCCAGAAGAGCTCAACGCATGGACTCCTTCAGATCAGAGTTGGCGTGTTGAAAGCTAA

Upstream 100 bases:

>100_bases
ATTCATTTATGGGGTTGTGATCATTTGCTCCAGCAGGATGGATTGGCTTGCCAAGGGGCAACTCCAACACGGACGATGGC
CGGACTAACGACTGATCAAC

Downstream 100 bases:

>100_bases
GGCTGCAAGGTTTGATACGCCTGATTGGGGCAATACGAATCCAGGCCAATAGGTCAGATTTATATCTCAGTCTTGCTCGT
GAAACCTGTCCCAGCGGAAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MAVERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQLAPSRELAGEHYGVHRERPFFAGLVDFITSGPVVAMVWEGD
GVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSDGPDTAQFEINLWFSPEELNAWTPSDQSWRVES

Sequences:

>Translated_152_residues
MAVERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQLAPSRELAGEHYGVHRERPFFAGLVDFITSGPVVAMVWEGD
GVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSDGPDTAQFEINLWFSPEELNAWTPSDQSWRVES
>Mature_151_residues
AVERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQLAPSRELAGEHYGVHRERPFFAGLVDFITSGPVVAMVWEGDG
VIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSDGPDTAQFEINLWFSPEELNAWTPSDQSWRVES

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=59.0604026845638, Blast_Score=190, Evalue=4e-49,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=59.0604026845638, Blast_Score=190, Evalue=4e-49,
Organism=Homo sapiens, GI37693993, Length=150, Percent_Identity=58.6666666666667, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=55.7046979865772, Blast_Score=179, Evalue=6e-46,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=55.7046979865772, Blast_Score=179, Evalue=6e-46,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=55.7046979865772, Blast_Score=179, Evalue=6e-46,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=55.7046979865772, Blast_Score=179, Evalue=6e-46,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=55.7046979865772, Blast_Score=179, Evalue=7e-46,
Organism=Homo sapiens, GI4826862, Length=143, Percent_Identity=54.5454545454545, Blast_Score=163, Evalue=4e-41,
Organism=Homo sapiens, GI37574614, Length=138, Percent_Identity=34.0579710144928, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7019465, Length=138, Percent_Identity=34.0579710144928, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=32.3529411764706, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788866, Length=142, Percent_Identity=45.0704225352113, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17506807, Length=150, Percent_Identity=52, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17507605, Length=85, Percent_Identity=41.1764705882353, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=149, Percent_Identity=53.0201342281879, Blast_Score=174, Evalue=5e-45,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=56.0810810810811, Blast_Score=182, Evalue=9e-47,
Organism=Drosophila melanogaster, GI18860097, Length=153, Percent_Identity=28.7581699346405, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PROM3 (A2CDK0)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018825.1
- ProteinModelPortal:   A2CDK0
- SMR:   A2CDK0
- STRING:   A2CDK0
- GeneID:   4776970
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_28301
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16610; Mature: 16479

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQLAPSRELAGEHYGVHRERPFF
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEHHHCCCCHHHCCCCCCCCCCCCHH
AGLVDFITSGPVVAMVWEGDGVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSD
HHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCCCCCCCCCEEECEEEEECCCEEEECCC
GPDTAQFEINLWFSPEELNAWTPSDQSWRVES
CCCCEEEEEEEEECHHHCCCCCCCCCCEEECC
>Mature Secondary Structure 
AVERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQLAPSRELAGEHYGVHRERPFF
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEHHHCCCCHHHCCCCCCCCCCCCHH
AGLVDFITSGPVVAMVWEGDGVIASARKLIGATKPLEAEPGTIRGDLAVNIGRNVIHGSD
HHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCCCCCCCCCEEECEEEEECCCEEEECCC
GPDTAQFEINLWFSPEELNAWTPSDQSWRVES
CCCCEEEEEEEEECHHHCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA