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The map label for this gene is ndhD1 [H]

Identifier: 124023557

GI number: 124023557

Start: 1618573

End: 1620144

Strand: Reverse

Name: ndhD1 [H]

Synonym: P9303_18571

Alternate gene names: 124023557

Gene position: 1620144-1618573 (Counterclockwise)

Preceding gene: 124023558

Following gene: 124023556

Centisome position: 60.39

GC content: 54.83

Gene sequence:

>1572_bases
ATGGACGCCAATTTGCCGCTGACGGCTGCGTCCCAGGCCTCATTCCCCTGGCTTTCCCTGATCGTGCTGCTGCCGGCAAT
GGGTGCCCTGCTGATGCCTCTGTTGCCAGGGAATGAAACAAGTAACTCCCAGGCACCACGAAATTTTGCACTGGCCTTTC
TGCTGGTGGATTTCGTGCTCATGCTGGTTGTGTTTAGCCGCATGTTTGATGGCCAGGATGGAGGGCTTCAGCTGGTTGAA
CGGGTTAGTTGGATTCCCTTCATTGGCCTGGAGTGGTCTCTCGGAGCAGACGGCCTTTCGGCTCCTCTGGTTGTACTTAG
CGGGCTGATCACTCTTCTTGCCGTGGCAGCTAGCTGGAAGGTGCAAAGCAAGACAAGGCTTTATTTCGCCCTGTTGTTGG
TTCAGGCTTCTGCCCAGGGGCTGGTTTTCCTCTCTCAAGATTTCCTGCTGTTCTTTCTTGCTTGGGAACTAGAGCTGGTT
CCGGTCTACCTGCTAATTGCCATCTGGGGCGGAAGCAGACGTCTATATGCCGCCACCAAATTCATTCTCTACACCGCTCT
AGCGTCTTTACTGATCCTGATCAGCGGACTCGCTCTGGCACTTTCGGGTGGTGAGTTCACGCTCAACCTCACTGAGCTGG
CCAATCGATCTCCAGAAGGCAGCCTTGGACTCCTCTGTTATCTGGGCTTTCTGGTGGGCTTTGGCGTAAAGCTACCGATG
TTTCCTCTCCACACCTGGCTGCCAGATGCCCACGGAGAAGCCAACGCACCAGTGTCGATGCTGCTGGCAGGGGTACTCCT
AAAGATGGGTGGCTATGCCCTTTTGCGCTTCAACGTGCAAATGCTGCCTGATGCTCATCTCCAGCTAGCGCCGGCCCTGA
TCGTGATTGGGATCGTCAACATCATCTACGGAGCACTCAACGCCTTTGCTCAAGACAACGTGAAACGACGAATTGCCTGC
AGTTCTGTGAGCCACATGGGCTTCGTTCTGTTGGGTATCGGCGCGATCGATGCTCTCGGGATCAGTGGGGCCATGCTGCA
GATGATTAGCCATGGCCTGATTGCAGCAGCCATGTTTTTCGTCACAGGAACGTTTTACGAACGCACGCAGACCCTCTCCA
TCCCCAACATGGGTGGCCTGGCCAAGGTCTTGCCAATCACCTTCGCTTTTTTCTTGGCCAGCTCCCTGGCTTCCCTCGCC
CTGCCAGGGATGAGCGGCTTTGTCAGTGAAATCACCGTCTTCCTCGGCATCATTAGTCAGGAAGGATTCACTTCAATATT
CAGGGTTATCACCATCGTGCTGGCGGCGATTGGACTAGTGCTTACCCCCGTCTATTTGCTGTCGATGTGTCGACGGGTCT
TTTTTGGCCCCAGGATTCCCGCCCTTGCAATGATCGAAGACATCAACCCCAGAGAGCTGACCATTGGGCTCAGTCTGATT
GTGCCCACGTTGGTGATCGGATTTTGGCCTCGAGTCGCCATCGATCTCTATGAGGCTTCAACCAATGCTCTCGCTGACCG
ACTGATTAGCCATAGCTTGGTAGCCCAAGGTTCCCTGCTACCCCTTGGCTGA

Upstream 100 bases:

>100_bases
GACAGGAGGGAGCCACTGGCAACCTCAAATTGAGGATGAGTAGATATACTCAAGCGCCCACCCCGGGGCTGATCAGTTCC
TTCGCATTCTCTTGCCTGCC

Downstream 100 bases:

>100_bases
ATAATGCCTGTTGCTGTGAACGAAATAAAGTCGCCAGCCCTCCTCCAGGGTGAAGGAATCCCAAACTTCTCTGCCATTAC
TGCTCAACAAGTTCAGGATC

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPGNETSNSQAPRNFALAFLLVDFVLMLVVFSRMFDGQDGGLQLVE
RVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWKVQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELV
PVYLLIAIWGGSRRLYAATKFILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVNIIYGALNAFAQDNVKRRIAC
SSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFFVTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLA
LPGMSGFVSEITVFLGIISQEGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLVAQGSLLPLG

Sequences:

>Translated_523_residues
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPGNETSNSQAPRNFALAFLLVDFVLMLVVFSRMFDGQDGGLQLVE
RVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWKVQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELV
PVYLLIAIWGGSRRLYAATKFILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVNIIYGALNAFAQDNVKRRIAC
SSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFFVTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLA
LPGMSGFVSEITVFLGIISQEGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLVAQGSLLPLG
>Mature_523_residues
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPGNETSNSQAPRNFALAFLLVDFVLMLVVFSRMFDGQDGGLQLVE
RVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWKVQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELV
PVYLLIAIWGGSRRLYAATKFILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVNIIYGALNAFAQDNVKRRIAC
SSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFFVTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLA
LPGMSGFVSEITVFLGIISQEGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLVAQGSLLPLG

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=376, Percent_Identity=29.7872340425532, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI251831117, Length=376, Percent_Identity=25.531914893617, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1788613, Length=521, Percent_Identity=37.8119001919386, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1788827, Length=235, Percent_Identity=32.3404255319149, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788831, Length=279, Percent_Identity=29.7491039426523, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788829, Length=298, Percent_Identity=27.5167785234899, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI2367154, Length=261, Percent_Identity=28.735632183908, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1788614, Length=465, Percent_Identity=25.3763440860215, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=224, Percent_Identity=31.6964285714286, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 55999; Mature: 55999

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPGNETSNSQAPRNFALAFLLVDFVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MLVVFSRMFDGQDGGLQLVERVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWK
HHHHHHHHHCCCCCHHHHHHHHCCCCEECEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
VQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELVPVYLLIAIWGGSRRLYAATK
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
HHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVN
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHH
IIYGALNAFAQDNVKRRIACSSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFVSEITVFLGIISQ
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
EGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHH
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLVAQGSLLPLG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPGNETSNSQAPRNFALAFLLVDFVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MLVVFSRMFDGQDGGLQLVERVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWK
HHHHHHHHHCCCCCHHHHHHHHCCCCEECEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
VQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELVPVYLLIAIWGGSRRLYAATK
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
HHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVN
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHH
IIYGALNAFAQDNVKRRIACSSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFVSEITVFLGIISQ
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
EGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHH
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLVAQGSLLPLG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA