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The map label for this gene is prlC [H]

Identifier: 124023556

GI number: 124023556

Start: 1616422

End: 1618569

Strand: Reverse

Name: prlC [H]

Synonym: P9303_18561

Alternate gene names: 124023556

Gene position: 1618569-1616422 (Counterclockwise)

Preceding gene: 124023557

Following gene: 124023555

Centisome position: 60.33

GC content: 54.38

Gene sequence:

>2148_bases
ATGCCTGTTGCTGTGAACGAAATAAAGTCGCCAGCCCTCCTCCAGGGTGAAGGAATCCCAAACTTCTCTGCCATTACTGC
TCAACAAGTTCAGGATCACATACCTGAACTTCTCTGTGCTCTTAACAAACAATTCAGCCAGCTGGAACAAGACCTAGACA
AAGTTTTGGCATCTGGCAAGAGCATTAATTGGCAACAAGTCATGTCTCCCCTGCATCAGCTTCAAGAGCAATTGCGTTGG
AGCTGGGGAGTTGTATCCCATCTCAACGGCGTCTGCAATACCTCCGAATTACGACAAGCTCACGCTGCACAGGAACCAGA
GGTGGTGCGCTTTGGAAACCTTATGGGCCAAAGCCAAACACTTCATCGTGCCCTGCGCCGGCTGAAAGACCAGACCTCAA
GGCCATTACTGGATTCGACTCAACAGCGGATTTTGAACGCGGAATTACTCTCCATGGATCAACGAGGCGTGGGTCTCGAT
GACCACGCACAGCAGGCTTTTAATACCACCAGTGAGCAACTGGCCGAGCTGTCGACCCGCTTCAGCAATCACGTCCTGGA
TGCAACCCAGGGATGGAGCCTGCTCCTCAATCGATCATCACAAGTTGACGGACTGCCGCAGAGGGCCTTGGAGGTTTTGT
CCTCAGCAGCCAAGCAAGCCGGAGATCACCGAGAAGACGGTGGAGAACCGACAGCAGAGCAGGGTCCCTGGCGATTAGGT
CTAGATATGCCCCGCTACATCCCCTTCATCACCCATGCAAAAGATCGAGGGCTACGTGAAACGCTCTACAAGGCTCATGT
GAGTAGAGCGAGTGCAGGTGAGTTAAACAATCAACCATTGATTGAAGAGCTGCTAAGCCTTCGGCTTGAGCAAGCTCAAA
GGCTTGGCTACATGAACTGGGCTGAACTCAGCCTGGCCAGCAAAATGGCCGAGGGCGTTGAGGCCGTCGAGCAGTTGCTT
GAGGAGTTGCGTGCTGCCGCTTTACCCGCCGCCCAAACGGAGTTAATTGAGCTCGAGGCCTGTGCCAAAAAACATGGAGC
TCCAGAGGCCAGCCAGCTCAAACCATGGGATGTGAACTTCTGGGCTGAACGGCTGAGGCAAGAGCGCTTTGACCTTGATC
AAGAAGCGCTGCGCCCTTGGTTCCCCCTGCCACAGGTTTTGGAAGGTTTGTTCGGACTTTGTGAACGTCTTTTTGGCATT
CGCATTCAAAGTGCCGACGGCGAGGCTCCGATCTGGCATCAAGACGTGCGTTATTTCCGGGTGTTGGATGCCAATGGTTC
AGACCTGGCAGCGTTCTACCTCGATCCCTATAGCCGACCAGCCAGCAAGCGAGGGGGGGCATGGATGGACGAATGCCTGA
TACGCAGCAAAAGCCTCGAGGGCCAATCGATTCTTCCAGTGGCCTATTTGATTTGTAATCAGACCCCACCGCAAGCAGAT
ACACCAAGTCTGATGAGCTTCGATGAGGTGGAGACTTTGTTCCATGAGTTCGGCCATGGTCTTCAGCACATGCTCACGAC
CGTTGAGTATCCACAGGCTGCAGGAATCAACAACGTGGAATGGGACGCAGTGGAACTGCCTAGCCAGTTCATGGAGAACT
GGTGCCTCGATCGCACCACGTTGATGGGGATGGCACGTCACTGGCGGACTGGCGAACCGCTTCCGGAGGAGGAGTTCGCA
AAATTGCGCTCCAGCCGCACCTTTAATGCCGGTTTGGCAACTCTGCGCCAGGTGCATTTCGCTCTCACTGATCTGCGCTT
GCATAGTTGCTGGACACCAGATCTCGGCGTGACCCCAGATCAGCTTCGCCGTCAGATTGCTGAGACCACCACGGTGATGC
TTCCGATCGCCGAAGATAAATTCCTCTGTGGCTTTGGCCACATCTTCGCCGGTGGTTATTCTGCCGGGTACTACTCCTAC
AAGTGGGCAGAAGTTCTTAGTGCTGATGCCTTTGCTGCCTTTGAGGAAGCTGGTCTGGAACTTGAAGATCAAGTTCGACT
CACTGGCGCTCGCTTTCGCGACACAGTTCTCAGTTTGGGAGGTAGCCATTCCCCAGCAGACGTCTATGAGCAATTCCGCG
GGCGACCAGCGACCACCGAGGCATTGATTCGCCATTCCGGCTTAGCCGCAAGCGCTGCGGATCAGTGA

Upstream 100 bases:

>100_bases
CGCCATCGATCTCTATGAGGCTTCAACCAATGCTCTCGCTGACCGACTGATTAGCCATAGCTTGGTAGCCCAAGGTTCCC
TGCTACCCCTTGGCTGAATA

Downstream 100 bases:

>100_bases
GGAGATGGCTGAAGAGACACCGCACTCTCTTAACCCCCTAGCGTTATCACAAAGCTGGGGCCAAGACGAGCATGACGATA
TCCACACGGCACCACTGATT

Product: M3 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MPVAVNEIKSPALLQGEGIPNFSAITAQQVQDHIPELLCALNKQFSQLEQDLDKVLASGKSINWQQVMSPLHQLQEQLRW
SWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQTLHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLD
DHAQQAFNTTSEQLAELSTRFSNHVLDATQGWSLLLNRSSQVDGLPQRALEVLSSAAKQAGDHREDGGEPTAEQGPWRLG
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYMNWAELSLASKMAEGVEAVEQLL
EELRAAALPAAQTELIELEACAKKHGAPEASQLKPWDVNFWAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGI
RIQSADGEAPIWHQDVRYFRVLDANGSDLAAFYLDPYSRPASKRGGAWMDECLIRSKSLEGQSILPVAYLICNQTPPQAD
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTTLMGMARHWRTGEPLPEEEFA
KLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPDQLRRQIAETTTVMLPIAEDKFLCGFGHIFAGGYSAGYYSY
KWAEVLSADAFAAFEEAGLELEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ

Sequences:

>Translated_715_residues
MPVAVNEIKSPALLQGEGIPNFSAITAQQVQDHIPELLCALNKQFSQLEQDLDKVLASGKSINWQQVMSPLHQLQEQLRW
SWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQTLHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLD
DHAQQAFNTTSEQLAELSTRFSNHVLDATQGWSLLLNRSSQVDGLPQRALEVLSSAAKQAGDHREDGGEPTAEQGPWRLG
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYMNWAELSLASKMAEGVEAVEQLL
EELRAAALPAAQTELIELEACAKKHGAPEASQLKPWDVNFWAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGI
RIQSADGEAPIWHQDVRYFRVLDANGSDLAAFYLDPYSRPASKRGGAWMDECLIRSKSLEGQSILPVAYLICNQTPPQAD
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTTLMGMARHWRTGEPLPEEEFA
KLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPDQLRRQIAETTTVMLPIAEDKFLCGFGHIFAGGYSAGYYSY
KWAEVLSADAFAAFEEAGLELEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ
>Mature_714_residues
PVAVNEIKSPALLQGEGIPNFSAITAQQVQDHIPELLCALNKQFSQLEQDLDKVLASGKSINWQQVMSPLHQLQEQLRWS
WGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQTLHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLDD
HAQQAFNTTSEQLAELSTRFSNHVLDATQGWSLLLNRSSQVDGLPQRALEVLSSAAKQAGDHREDGGEPTAEQGPWRLGL
DMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYMNWAELSLASKMAEGVEAVEQLLE
ELRAAALPAAQTELIELEACAKKHGAPEASQLKPWDVNFWAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGIR
IQSADGEAPIWHQDVRYFRVLDANGSDLAAFYLDPYSRPASKRGGAWMDECLIRSKSLEGQSILPVAYLICNQTPPQADT
PSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTTLMGMARHWRTGEPLPEEEFAK
LRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPDQLRRQIAETTTVMLPIAEDKFLCGFGHIFAGGYSAGYYSYK
WAEVLSADAFAAFEEAGLELEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=704, Percent_Identity=27.2727272727273, Blast_Score=249, Evalue=7e-66,
Organism=Homo sapiens, GI14149738, Length=699, Percent_Identity=25.1788268955651, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI156105687, Length=453, Percent_Identity=29.3598233995585, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1789913, Length=695, Percent_Identity=38.8489208633094, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1787819, Length=620, Percent_Identity=32.258064516129, Blast_Score=260, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71999758, Length=592, Percent_Identity=23.9864864864865, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI32565901, Length=661, Percent_Identity=25.1134644478064, Blast_Score=107, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319793, Length=495, Percent_Identity=29.6969696969697, Blast_Score=221, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6322715, Length=371, Percent_Identity=26.1455525606469, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356111, Length=708, Percent_Identity=30.225988700565, Blast_Score=286, Evalue=4e-77,
Organism=Drosophila melanogaster, GI20129717, Length=460, Percent_Identity=25.6521739130435, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 79920; Mature: 79789

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAVNEIKSPALLQGEGIPNFSAITAQQVQDHIPELLCALNKQFSQLEQDLDKVLASGK
CCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SINWQQVMSPLHQLQEQLRWSWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCHHH
LHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLDDHAQQAFNTTSEQLAELSTR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHH
FSNHVLDATQGWSLLLNRSSQVDGLPQRALEVLSSAAKQAGDHREDGGEPTAEQGPWRLG
HHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYMNW
CCCHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
AELSLASKMAEGVEAVEQLLEELRAAALPAAQTELIELEACAKKHGAPEASQLKPWDVNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
WAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGIRIQSADGEAPIWHQDVRYFR
HHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHCCCEEE
VLDANGSDLAAFYLDPYSRPASKRGGAWMDECLIRSKSLEGQSILPVAYLICNQTPPQAD
EECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMGMARHWRTGEPLPEEEFAKLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPD
HHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QLRRQIAETTTVMLPIAEDKFLCGFGHIFAGGYSAGYYSYKWAEVLSADAFAAFEEAGLE
HHHHHHHHHHEEEEEECCCCEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PVAVNEIKSPALLQGEGIPNFSAITAQQVQDHIPELLCALNKQFSQLEQDLDKVLASGK
CCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SINWQQVMSPLHQLQEQLRWSWGVVSHLNGVCNTSELRQAHAAQEPEVVRFGNLMGQSQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCHHH
LHRALRRLKDQTSRPLLDSTQQRILNAELLSMDQRGVGLDDHAQQAFNTTSEQLAELSTR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHH
FSNHVLDATQGWSLLLNRSSQVDGLPQRALEVLSSAAKQAGDHREDGGEPTAEQGPWRLG
HHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEC
LDMPRYIPFITHAKDRGLRETLYKAHVSRASAGELNNQPLIEELLSLRLEQAQRLGYMNW
CCCHHHHHHHHCHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCH
AELSLASKMAEGVEAVEQLLEELRAAALPAAQTELIELEACAKKHGAPEASQLKPWDVNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
WAERLRQERFDLDQEALRPWFPLPQVLEGLFGLCERLFGIRIQSADGEAPIWHQDVRYFR
HHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHCCCEEE
VLDANGSDLAAFYLDPYSRPASKRGGAWMDECLIRSKSLEGQSILPVAYLICNQTPPQAD
EECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCC
TPSLMSFDEVETLFHEFGHGLQHMLTTVEYPQAAGINNVEWDAVELPSQFMENWCLDRTT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMGMARHWRTGEPLPEEEFAKLRSSRTFNAGLATLRQVHFALTDLRLHSCWTPDLGVTPD
HHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QLRRQIAETTTVMLPIAEDKFLCGFGHIFAGGYSAGYYSYKWAEVLSADAFAAFEEAGLE
HHHHHHHHHHEEEEEECCCCEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LEDQVRLTGARFRDTVLSLGGSHSPADVYEQFRGRPATTEALIRHSGLAASAADQ
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]