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The map label for this gene is hemH

Identifier: 124022475

GI number: 124022475

Start: 705309

End: 706484

Strand: Direct

Name: hemH

Synonym: P9303_07661

Alternate gene names: 124022475

Gene position: 705309-706484 (Clockwise)

Preceding gene: 124022468

Following gene: 124022477

Centisome position: 26.29

GC content: 53.06

Gene sequence:

>1176_bases
ATGGCCCGGGTCGGTGTCCTCTTGATGAATCTTGGGGGACCTGAACGTATCCAGGATGTAGGGCCTTTTCTCTTTAATAT
TTTTGCCGATCCGGAGATCATTCGGCTGCCTAACCCCGCTCTTCAGAGGCCTCTGGCCTGGTTGATCAGCACGCTGCGCA
GCAGTAAATCCGAGCAGGCTTACCGCTCAATAGGGGGCGGTTCACCTCTGCGGCGGATCACTGAACAACAGGCTCGGGAG
TTGCAGAGCTTGCTTCGGCAACGCGGTATCGATGCCACGAGCTATGTGGCGATGCGTTATTGGCATCCCTTCACAGAATC
CGCTGTCGCAGATATCAAAGCTGATGGGATTGATCAGGTGGTGGTGCTTCCCCTCTACCCTCATTTTTCGATTAGTACCA
GTGGCTCGAGTTTTCGAGAGTTGCAGCGCTTGCGACAGACTGATGAATCTTTCCGCAAGCTGCCAATACGTTGTATCCGC
AGCTGGTACGACCACCCTGGATATGTTCTTGCCATGGCGGAGTTGATCGCTGAGCAGGTTCGACTGAGTGATGTGCCTGA
AGAAGCTCAAGTGTTTTTTAGTGCTCATGGAGTGCCCAAGAGCTATGTCGAACAAGCAGGTGATCCATACCAGAAGGAGA
TCGAGGCTTGTACAACCTTGATCATGGCTGAGCTGGAAAACCTTCTTGGCTATGGCAATCCTCATTCCCTTGCCTATCAA
AGCCGAGTGGGTCCAGAGGAATGGATTCAGCCCTATACCGATGAAGTTATTGAGCAGCTTGGTGAGGCTGGTACACGGGA
TTTAGTGGTTGTGCCGATCAGCTTTGTGAGCGAACACATCGAAACTCTCGCCGAGCTTGATATCGAATACCGCGAGCTGG
CGACCGAAGCAGGGATTGTTCATTTCAGGAGGGTGCCTGCTCTTGATACTTACCCCACATTCATTGAGGGCCTGGCCGAT
CTGGTTGGATCCAGTCTTGAGGGGCCAGAGATCAATCTCGATGAGGCTGCCAAGCTGGCCGGTCGAGTGAAGTTCTATCC
CCAGGAGAGATGGCAATGGGGCTTGAATACCAGTTCTGAGGCATGGAATGGACGCATAGCCATGCTTGGTTTTGCGGCTT
TTTTGTTGGAGCTGATCAGTGGCCATGGCCCTTTGCACGCGATCGGTCTGCTCTGA

Upstream 100 bases:

>100_bases
TTGATTAGCTCGTTGCTCAGCTCCATGGCCCTGTAGGGATGGTGCCACCTTGGCGTTGATGGCAGCTACCCTCAAGTCCC
TATAAAGAACTCTCTTCTAT

Downstream 100 bases:

>100_bases
GTGCTGGCTAGTTAAGGGTGGTCTCACTCTTCTTGTTGGTTCGTTTGTGGGATGACTGTTCTCAACGGAGTCCATTTGTA
TTGGGGCATTCGCCCTCAGG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQAYRSIGGGSPLRRITEQQARE
LQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQVVVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIR
SWYDHPGYVLAMAELIAEQVRLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
SRVGPEEWIQPYTDEVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIVHFRRVPALDTYPTFIEGLAD
LVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSEAWNGRIAMLGFAAFLLELISGHGPLHAIGLL

Sequences:

>Translated_391_residues
MARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQAYRSIGGGSPLRRITEQQARE
LQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQVVVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIR
SWYDHPGYVLAMAELIAEQVRLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
SRVGPEEWIQPYTDEVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIVHFRRVPALDTYPTFIEGLAD
LVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSEAWNGRIAMLGFAAFLLELISGHGPLHAIGLL
>Mature_390_residues
ARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQAYRSIGGGSPLRRITEQQAREL
QSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQVVVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIRS
WYDHPGYVLAMAELIAEQVRLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQS
RVGPEEWIQPYTDEVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIVHFRRVPALDTYPTFIEGLADL
VGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSEAWNGRIAMLGFAAFLLELISGHGPLHAIGLL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=337, Percent_Identity=37.3887240356083, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI60499025, Length=337, Percent_Identity=37.3887240356083, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=32.6219512195122, Blast_Score=135, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=35.9882005899705, Blast_Score=202, Evalue=7e-53,
Organism=Drosophila melanogaster, GI17864156, Length=332, Percent_Identity=34.6385542168675, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=32.183908045977, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45552018, Length=173, Percent_Identity=38.728323699422, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_PROM3 (A2C7Q7)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016782.1
- ProteinModelPortal:   A2C7Q7
- SMR:   A2C7Q7
- STRING:   A2C7Q7
- GeneID:   4778288
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_07661
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 43747; Mature: 43616

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQA
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCHHHHH
YRSIGGGSPLRRITEQQARELQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQV
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCE
VVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIRSWYDHPGYVLAMAELIAEQV
EEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
HHCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
SRVGPEEWIQPYTDEVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIV
HCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHH
HFRRVPALDTYPTFIEGLADLVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSE
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCC
AWNGRIAMLGFAAFLLELISGHGPLHAIGLL
CCCCHHHHHHHHHHHHHHHHCCCCCEECCCC
>Mature Secondary Structure 
ARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQA
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCHHHHH
YRSIGGGSPLRRITEQQARELQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQV
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCE
VVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIRSWYDHPGYVLAMAELIAEQV
EEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
HHCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
SRVGPEEWIQPYTDEVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIV
HCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHH
HFRRVPALDTYPTFIEGLADLVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSE
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCC
AWNGRIAMLGFAAFLLELISGHGPLHAIGLL
CCCCHHHHHHHHHHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA