Click here to switch to the map view.

The map label for this gene is ilvB [H]

Identifier: 124022477

GI number: 124022477

Start: 706693

End: 708474

Strand: Direct

Name: ilvB [H]

Synonym: P9303_07681

Alternate gene names: 124022477

Gene position: 706693-708474 (Clockwise)

Preceding gene: 124022475

Following gene: 124022478

Centisome position: 26.34

GC content: 50.84

Gene sequence:

>1782_bases
GTGACCTTGACTTCTTCAACCACGGCTCTCGGTGGTTCATCACAACAAGAGCAAAAACGTATTACGGGCGCCGATGCCCT
GATGGATGCTCTTCGCCGCAACGGTGTTGACATCATCTTTGGTTATCCAGGTGGTGCAATCCTTCCCATTTACGACGCCG
TTCATAAGGCGGAGCAGCAGGGATGGTTGAAACACATCCTTGTTCGCCATGAGCAGGGGGGTGCCCATGCGGCGGATGGC
TATGCAAGGGCTACAGGTCGTGTTGGAGTTTGCTTTGGCACCTCTGGGCCAGGTGCAACCAATCTGGTTACTGGTATCGC
CACGGCTCAGATGGATTCAGTTCCAATGGTGGTGATCACAGGACAGGTCCCTCGACCATGCATTGGTACAGATGCTTTTC
AGGAAACTGATATTTTCGGGATCACTCTGCCTATCGTTAAACACTCCTGGGTTGTTCGCGATCCGGGTGATTTGGCTTCG
GTTGTTGCTCAAGCATTTTTTATTGCAGCTTCTGGGAGACCTGGTCCGGTCTTGATTGATATCCCTAAGGATGTGGGCCA
GGAGGAATTCGACTATCAGCCAGTTGAACCTGGATCCGTAGTGCCTGCAGGATTTCACCGATTCCCGGCTCCAGAACTTT
CCTCAATTGAGGCGGCTCTCGATTTAATTGATGATGCTCAGAGGCCTCTCCTTTACGTTGGCGGAGGAGTTATTTCTGCC
GGAGCTCACGAGAGTCTTAAGGGTTTTGCAGAACGTCACCAGATACCTGTCACCACCACATTGATGGGTAAGGGGGCGTT
TGATGAGCGACATCCTTTGGCTTTGGGGATGTTGGGAATGCATGGCACTGCCTATGCCAACTTTGCAGTTACTGAATGTG
ATTTGTTGATCGCTGTTGGCGCACGTTTCGATGACCGGGTTACAGGCAAGCTTGATACTTTTGCACCCCGCGCAAGAGTG
ATTCATTTTGAAATTGATCCAGCAGAAGTAGCTAAGAACCGACGTCCTGATGTTGCGGTATTGGGTGATGTTGGTGTCAG
CTTGGTGAAGTTATTGGACTTGAGTAAGCAAAAGCCTGTTGAGTTGAGGACTTCAGCTTGGCTAACTCGTATTGAGAGTT
GGAAGGACCTTTACCCCTTGATGACTCCGCCTGAGGAGGGGCCAATTTATCCGCAGGAGGTGCTTTTGGCGATAAGGGAC
TTGGCTCCTGAGGCCTACATCACAACTGATGTTGGCCAGCATCAGATGTGGGCGGCTCAATATTTACGTAATGGGCCTCG
TCAGTGGATCAGTAGCGCGGGATTGGGAACGATGGGTTTCGGGATGCCAGCTGCTATTGGTGTTCAAATTGCTTTGCCAG
ATGAGCAGGTTGTTTGTATCGCTGGTGATTCCAGCATCCTGATGAATATTCAGGAGTTGGGAACACTGATTGAGTACAAC
ATCCCAGCCAAGATTGTGATTGTGAACAACCAATGGCAAGGCATGGTTCGTCAGTGGCAGCAAAGCTTCTACGAAGATCG
TTATTCAGCCACTGACATGCTTCCGGGCATGCCTGATTTCGTGGCATTGGCGAAGGCCTTCAGGATTGGCGGGGTGTTGA
TCACTGAGCGAAAGGATCTCAGGTCAAGCTTGAAGCAGGCCCTTGCTACTCCAGGTCCGATGCTCATCGACGTGCATGTG
CGACGTGATGAAAATTGCTATCCGATGGTTCCTCCTGGCAAGAGCAACGCTCAAATGGTTGGTTTACCTAACCACCCTGA
ACTTTCTGGGGTTTCTCTCTAA

Upstream 100 bases:

>100_bases
TCACTGACGGATTGATTTTGCTGGTGATGGTGAAGAACCAATAGGCAATCTGTACGGCAGGCCCTTAATCTTTAGGAGCA
GACCATGCTTTGCCACTGCC

Downstream 100 bases:

>100_bases
TGCAACGACTGCAGTTTGTTCTTCTAAGCATTCTGCTTGTTTTGTTCATCGCACCATTGCCTGTCATGGCGGCGGAAGTG
CTGCGTGTGAGTGGCTCCTC

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTLTSSTTALGGSSQQEQKRITGADALMDALRRNGVDIIFGYPGGAILPIYDAVHKAEQQGWLKHILVRHEQGGAHAADG
YARATGRVGVCFGTSGPGATNLVTGIATAQMDSVPMVVITGQVPRPCIGTDAFQETDIFGITLPIVKHSWVVRDPGDLAS
VVAQAFFIAASGRPGPVLIDIPKDVGQEEFDYQPVEPGSVVPAGFHRFPAPELSSIEAALDLIDDAQRPLLYVGGGVISA
GAHESLKGFAERHQIPVTTTLMGKGAFDERHPLALGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDTFAPRARV
IHFEIDPAEVAKNRRPDVAVLGDVGVSLVKLLDLSKQKPVELRTSAWLTRIESWKDLYPLMTPPEEGPIYPQEVLLAIRD
LAPEAYITTDVGQHQMWAAQYLRNGPRQWISSAGLGTMGFGMPAAIGVQIALPDEQVVCIAGDSSILMNIQELGTLIEYN
IPAKIVIVNNQWQGMVRQWQQSFYEDRYSATDMLPGMPDFVALAKAFRIGGVLITERKDLRSSLKQALATPGPMLIDVHV
RRDENCYPMVPPGKSNAQMVGLPNHPELSGVSL

Sequences:

>Translated_593_residues
MTLTSSTTALGGSSQQEQKRITGADALMDALRRNGVDIIFGYPGGAILPIYDAVHKAEQQGWLKHILVRHEQGGAHAADG
YARATGRVGVCFGTSGPGATNLVTGIATAQMDSVPMVVITGQVPRPCIGTDAFQETDIFGITLPIVKHSWVVRDPGDLAS
VVAQAFFIAASGRPGPVLIDIPKDVGQEEFDYQPVEPGSVVPAGFHRFPAPELSSIEAALDLIDDAQRPLLYVGGGVISA
GAHESLKGFAERHQIPVTTTLMGKGAFDERHPLALGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDTFAPRARV
IHFEIDPAEVAKNRRPDVAVLGDVGVSLVKLLDLSKQKPVELRTSAWLTRIESWKDLYPLMTPPEEGPIYPQEVLLAIRD
LAPEAYITTDVGQHQMWAAQYLRNGPRQWISSAGLGTMGFGMPAAIGVQIALPDEQVVCIAGDSSILMNIQELGTLIEYN
IPAKIVIVNNQWQGMVRQWQQSFYEDRYSATDMLPGMPDFVALAKAFRIGGVLITERKDLRSSLKQALATPGPMLIDVHV
RRDENCYPMVPPGKSNAQMVGLPNHPELSGVSL
>Mature_592_residues
TLTSSTTALGGSSQQEQKRITGADALMDALRRNGVDIIFGYPGGAILPIYDAVHKAEQQGWLKHILVRHEQGGAHAADGY
ARATGRVGVCFGTSGPGATNLVTGIATAQMDSVPMVVITGQVPRPCIGTDAFQETDIFGITLPIVKHSWVVRDPGDLASV
VAQAFFIAASGRPGPVLIDIPKDVGQEEFDYQPVEPGSVVPAGFHRFPAPELSSIEAALDLIDDAQRPLLYVGGGVISAG
AHESLKGFAERHQIPVTTTLMGKGAFDERHPLALGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDTFAPRARVI
HFEIDPAEVAKNRRPDVAVLGDVGVSLVKLLDLSKQKPVELRTSAWLTRIESWKDLYPLMTPPEEGPIYPQEVLLAIRDL
APEAYITTDVGQHQMWAAQYLRNGPRQWISSAGLGTMGFGMPAAIGVQIALPDEQVVCIAGDSSILMNIQELGTLIEYNI
PAKIVIVNNQWQGMVRQWQQSFYEDRYSATDMLPGMPDFVALAKAFRIGGVLITERKDLRSSLKQALATPGPMLIDVHVR
RDENCYPMVPPGKSNAQMVGLPNHPELSGVSL

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=584, Percent_Identity=26.8835616438356, Blast_Score=186, Evalue=8e-47,
Organism=Homo sapiens, GI21361361, Length=520, Percent_Identity=25.5769230769231, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI87081685, Length=559, Percent_Identity=46.3327370304114, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1790104, Length=569, Percent_Identity=45.6942003514938, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1786717, Length=572, Percent_Identity=33.7412587412587, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1787096, Length=558, Percent_Identity=27.9569892473118, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1788716, Length=553, Percent_Identity=28.9330922242315, Blast_Score=180, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17531299, Length=577, Percent_Identity=27.3830155979203, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17531301, Length=575, Percent_Identity=27.4782608695652, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17542570, Length=552, Percent_Identity=26.4492753623188, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323755, Length=578, Percent_Identity=45.5017301038062, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320816, Length=489, Percent_Identity=22.4948875255624, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323073, Length=497, Percent_Identity=24.3460764587525, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320588, Length=509, Percent_Identity=21.4145383104126, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922626, Length=562, Percent_Identity=26.6903914590747, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 63974; Mature: 63843

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTSSTTALGGSSQQEQKRITGADALMDALRRNGVDIIFGYPGGAILPIYDAVHKAEQQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHH
GWLKHILVRHEQGGAHAADGYARATGRVGVCFGTSGPGATNLVTGIATAQMDSVPMVVIT
HHHHHHHHEECCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
GQVPRPCIGTDAFQETDIFGITLPIVKHSWVVRDPGDLASVVAQAFFIAASGRPGPVLID
CCCCCCCCCCCCCCCCCEEEEEEEHHCCEEEEECCHHHHHHHHHHHEEEECCCCCCEEEE
IPKDVGQEEFDYQPVEPGSVVPAGFHRFPAPELSSIEAALDLIDDAQRPLLYVGGGVISA
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEC
GAHESLKGFAERHQIPVTTTLMGKGAFDERHPLALGMLGMHGTAYANFAVTECDLLIAVG
CCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEEEEEEC
ARFDDRVTGKLDTFAPRARVIHFEIDPAEVAKNRRPDVAVLGDVGVSLVKLLDLSKQKPV
CCCCCCCCCCHHCCCCCEEEEEEECCHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCCC
ELRTSAWLTRIESWKDLYPLMTPPEEGPIYPQEVLLAIRDLAPEAYITTDVGQHQMWAAQ
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
YLRNGPRQWISSAGLGTMGFGMPAAIGVQIALPDEQVVCIAGDSSILMNIQELGTLIEYN
HHHCCHHHHHHHCCCCCCCCCCCHHEEEEEECCCCCEEEEECCCHHEEEHHHHCCEEEEC
IPAKIVIVNNQWQGMVRQWQQSFYEDRYSATDMLPGMPDFVALAKAFRIGGVLITERKDL
CCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCEEEECCHHH
RSSLKQALATPGPMLIDVHVRRDENCYPMVPPGKSNAQMVGLPNHPELSGVSL
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TLTSSTTALGGSSQQEQKRITGADALMDALRRNGVDIIFGYPGGAILPIYDAVHKAEQQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHH
GWLKHILVRHEQGGAHAADGYARATGRVGVCFGTSGPGATNLVTGIATAQMDSVPMVVIT
HHHHHHHHEECCCCCCCCCCHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
GQVPRPCIGTDAFQETDIFGITLPIVKHSWVVRDPGDLASVVAQAFFIAASGRPGPVLID
CCCCCCCCCCCCCCCCCEEEEEEEHHCCEEEEECCHHHHHHHHHHHEEEECCCCCCEEEE
IPKDVGQEEFDYQPVEPGSVVPAGFHRFPAPELSSIEAALDLIDDAQRPLLYVGGGVISA
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEC
GAHESLKGFAERHQIPVTTTLMGKGAFDERHPLALGMLGMHGTAYANFAVTECDLLIAVG
CCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEEEEEEEEEEC
ARFDDRVTGKLDTFAPRARVIHFEIDPAEVAKNRRPDVAVLGDVGVSLVKLLDLSKQKPV
CCCCCCCCCCHHCCCCCEEEEEEECCHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCCC
ELRTSAWLTRIESWKDLYPLMTPPEEGPIYPQEVLLAIRDLAPEAYITTDVGQHQMWAAQ
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
YLRNGPRQWISSAGLGTMGFGMPAAIGVQIALPDEQVVCIAGDSSILMNIQELGTLIEYN
HHHCCHHHHHHHCCCCCCCCCCCHHEEEEEECCCCCEEEEECCCHHEEEHHHHCCEEEEC
IPAKIVIVNNQWQGMVRQWQQSFYEDRYSATDMLPGMPDFVALAKAFRIGGVLITERKDL
CCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCEEEECCHHH
RSSLKQALATPGPMLIDVHVRRDENCYPMVPPGKSNAQMVGLPNHPELSGVSL
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]