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The map label for this gene is bioF [H]

Identifier: 124026573

GI number: 124026573

Start: 1527885

End: 1529027

Strand: Direct

Name: bioF [H]

Synonym: NATL1_18681

Alternate gene names: 124026573

Gene position: 1527885-1529027 (Clockwise)

Preceding gene: 124026571

Following gene: 124026574

Centisome position: 81.94

GC content: 39.81

Gene sequence:

>1143_bases
ATGCCTGAAATCCCTAATTCTAGAATTCGTAAACTCAGGACTTGGGCTCCAGGAAAAAGATCATCAGAGTTAATTGGGGA
AGATGAAAATAAAAATCAAATCACACTAATTGACCTAGCAAGTAATGACTATCTAGACCTATCAAGACATCCATTATTAA
TTGAGGCAGCCAGACATACCTTGGAAACTGATGGGGTTGGTTCTGGAGGATCAAGATTTATCACCGGCAGTAGAAATATT
CATCAAAAACTTGAAACGAAACTTGCTGAATGGCTTGATCGTGAGATTGTCCTAATTTACCCGAGTGGTTTCCAGGCGAA
CCTGGCTGCAGTTTTAGCACTTTCTGATCGTCATACTCCTGTTATTTGTGATCGTCTGATACACCATTCTCTACTCGTTG
GAGTCAAAGCGAGTGGAGCAAAGCTCTTTAGATTCAAACACAATAATTTATCTGAACTAGAAAAGCTTTTAAAAAAATCT
AGACAAAACAATCCTCGAAAACAACCTCTTGTAATTACTGAAAGCCTTTTCAGCATGGAGGGTACAACAGCTCCCATAAA
AGAAATTTCAAAGCTATGCATTGAATACGATTCAAAGTTATTGATAGATGAAGCTCACGCGTTTGGAGTCATGGGTTCAG
CAGGAAGAGGTGAGTCATTTGAACTCAAAGAACCAATTTCAATTATCAGTGGAACTTTTGGTAAAGCGTTTGGAAGTGGA
GGAGCATTTCTAGCAACAGATAAGATAACAGGAAAAAATCTCATACAAAACTGTGGAGCATTTCGCTATACCACTGCATT
AGCTCCTCCACTCTGTGCAAGTGCTTTAGCTGCATTAAATCTAATTAAAAGCAACCCTAACTGGGGTAGCGAACTGAAAA
AGAAATCAAAAGCTTTAAGAGACAGATTGTCTCAAGTTGGTTGGCAACGACCTCCTGGTGAAGGCCCAATAATCTCCATA
ATTCTTGGTTCAGACAGATTAGCCATGGATTATCAAGAAAGACTTGAGGCACAAGGCCTTCTAACTGTTGCGATCCGACC
ACCAACTGTCCCCGAAGGTAAATCGAGACTCAGATTAGTGATCAGGCGAAATACACCAGATCAGGCCTTCGAAAGACTTA
TCGAAATTCTTAAAAACAAATGA

Upstream 100 bases:

>100_bases
CACATGATTTTTGACATGGATAAATAATGAAATCAAGAAACTCAAGAAAAAATGTTAAGCCAACACCCAAATCTTCAATC
CTAGAGGACAAAATAAAAAT

Downstream 100 bases:

>100_bases
AAGAAATAATCGCTATGCATGGATGGGCTGGTAATAGCAATCAATGGTCAAATTGGGAACAAATATTTAAGTGTTATGAA
TGGGAATGGCGAAATTCTGA

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MPEIPNSRIRKLRTWAPGKRSSELIGEDENKNQITLIDLASNDYLDLSRHPLLIEAARHTLETDGVGSGGSRFITGSRNI
HQKLETKLAEWLDREIVLIYPSGFQANLAAVLALSDRHTPVICDRLIHHSLLVGVKASGAKLFRFKHNNLSELEKLLKKS
RQNNPRKQPLVITESLFSMEGTTAPIKEISKLCIEYDSKLLIDEAHAFGVMGSAGRGESFELKEPISIISGTFGKAFGSG
GAFLATDKITGKNLIQNCGAFRYTTALAPPLCASALAALNLIKSNPNWGSELKKKSKALRDRLSQVGWQRPPGEGPIISI
ILGSDRLAMDYQERLEAQGLLTVAIRPPTVPEGKSRLRLVIRRNTPDQAFERLIEILKNK

Sequences:

>Translated_380_residues
MPEIPNSRIRKLRTWAPGKRSSELIGEDENKNQITLIDLASNDYLDLSRHPLLIEAARHTLETDGVGSGGSRFITGSRNI
HQKLETKLAEWLDREIVLIYPSGFQANLAAVLALSDRHTPVICDRLIHHSLLVGVKASGAKLFRFKHNNLSELEKLLKKS
RQNNPRKQPLVITESLFSMEGTTAPIKEISKLCIEYDSKLLIDEAHAFGVMGSAGRGESFELKEPISIISGTFGKAFGSG
GAFLATDKITGKNLIQNCGAFRYTTALAPPLCASALAALNLIKSNPNWGSELKKKSKALRDRLSQVGWQRPPGEGPIISI
ILGSDRLAMDYQERLEAQGLLTVAIRPPTVPEGKSRLRLVIRRNTPDQAFERLIEILKNK
>Mature_379_residues
PEIPNSRIRKLRTWAPGKRSSELIGEDENKNQITLIDLASNDYLDLSRHPLLIEAARHTLETDGVGSGGSRFITGSRNIH
QKLETKLAEWLDREIVLIYPSGFQANLAAVLALSDRHTPVICDRLIHHSLLVGVKASGAKLFRFKHNNLSELEKLLKKSR
QNNPRKQPLVITESLFSMEGTTAPIKEISKLCIEYDSKLLIDEAHAFGVMGSAGRGESFELKEPISIISGTFGKAFGSGG
AFLATDKITGKNLIQNCGAFRYTTALAPPLCASALAALNLIKSNPNWGSELKKKSKALRDRLSQVGWQRPPGEGPIISII
LGSDRLAMDYQERLEAQGLLTVAIRPPTVPEGKSRLRLVIRRNTPDQAFERLIEILKNK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=343, Percent_Identity=30.6122448979592, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI284448556, Length=344, Percent_Identity=31.1046511627907, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=34.2939481268012, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=34.2939481268012, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=34.2939481268012, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4502025, Length=357, Percent_Identity=29.6918767507003, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI40316939, Length=357, Percent_Identity=29.6918767507003, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI4758668, Length=343, Percent_Identity=30.0291545189504, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI119220554, Length=359, Percent_Identity=27.0194986072423, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI5454084, Length=288, Percent_Identity=31.25, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1790046, Length=348, Percent_Identity=31.6091954022989, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=37.7521613832853, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71994529, Length=344, Percent_Identity=31.9767441860465, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=26.1111111111111, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=25.3481894150418, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=25.3481894150418, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=319, Percent_Identity=25.0783699059561, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=319, Percent_Identity=25.0783699059561, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=349, Percent_Identity=30.945558739255, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320267, Length=355, Percent_Identity=28.4507042253521, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=279, Percent_Identity=28.3154121863799, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24662918, Length=368, Percent_Identity=29.0760869565217, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17137420, Length=343, Percent_Identity=32.0699708454811, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17136286, Length=288, Percent_Identity=30.5555555555556, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24653280, Length=277, Percent_Identity=26.7148014440433, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24653276, Length=277, Percent_Identity=26.7148014440433, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24653278, Length=277, Percent_Identity=26.7148014440433, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41981; Mature: 41850

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIPNSRIRKLRTWAPGKRSSELIGEDENKNQITLIDLASNDYLDLSRHPLLIEAARHT
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHH
LETDGVGSGGSRFITGSRNIHQKLETKLAEWLDREIVLIYPSGFQANLAAVLALSDRHTP
HCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCH
VICDRLIHHSLLVGVKASGAKLFRFKHNNLSELEKLLKKSRQNNPRKQPLVITESLFSME
HHHHHHHHHHHHEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCC
GTTAPIKEISKLCIEYDSKLLIDEAHAFGVMGSAGRGESFELKEPISIISGTFGKAFGSG
CCCCCHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCC
GAFLATDKITGKNLIQNCGAFRYTTALAPPLCASALAALNLIKSNPNWGSELKKKSKALR
CCEEEECCCCHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DRLSQVGWQRPPGEGPIISIILGSDRLAMDYQERLEAQGLLTVAIRPPTVPEGKSRLRLV
HHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEE
IRRNTPDQAFERLIEILKNK
EECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEIPNSRIRKLRTWAPGKRSSELIGEDENKNQITLIDLASNDYLDLSRHPLLIEAARHT
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHHH
LETDGVGSGGSRFITGSRNIHQKLETKLAEWLDREIVLIYPSGFQANLAAVLALSDRHTP
HCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCH
VICDRLIHHSLLVGVKASGAKLFRFKHNNLSELEKLLKKSRQNNPRKQPLVITESLFSME
HHHHHHHHHHHHEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCC
GTTAPIKEISKLCIEYDSKLLIDEAHAFGVMGSAGRGESFELKEPISIISGTFGKAFGSG
CCCCCHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCC
GAFLATDKITGKNLIQNCGAFRYTTALAPPLCASALAALNLIKSNPNWGSELKKKSKALR
CCEEEECCCCHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DRLSQVGWQRPPGEGPIISIILGSDRLAMDYQERLEAQGLLTVAIRPPTVPEGKSRLRLV
HHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEE
IRRNTPDQAFERLIEILKNK
EECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA