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The map label for this gene is fumC [H]

Identifier: 124026571

GI number: 124026571

Start: 1523566

End: 1524960

Strand: Direct

Name: fumC [H]

Synonym: NATL1_18661

Alternate gene names: 124026571

Gene position: 1523566-1524960 (Clockwise)

Preceding gene: 124026570

Following gene: 124026573

Centisome position: 81.7

GC content: 36.42

Gene sequence:

>1395_bases
ATGTCCAACATGAAACGACTTGAGAAAGATAGCCTAGGTTCAATTGATGTTCCAAAGGATGCGCTATGGGGAGCTCAAAC
TCAACGCTCAATATTGAATTTTGCTATCGGGAATGAGGTCATACCACTCGAGATTATTCTTGCAATTGCCCAAATAAAAG
CCTCTGCTGCTCATGTAAACAATCATCTAGGTTTAATAACTACAGAAACTGCTCAATTTATTACCGAAGCAAGTTTAGAA
ATTATTGAAGGAAAACATAATGATCAATTCCCAGTGAGAGTTTGGCAAACAGGCAGTGGTACTCAAACCAATATGAACGT
CAATGAGGTGATCAGCAATATAGCTTCAAAACGTTCAAATAATGCGTTAGGTAGTCATAATCCAATACATCCCAATGATC
ATGTCAATTGCTCTCAATCAACAAACGATGTTTTTCCAGCTGCAATCCAAATAGCCACAATAGTAACCTTAAAAGATACA
TTAATACCTGAATTAACCAAACTCATTGATGTATTCCATCAAAAAAGTAAAGAGTGGAAAGATATTATAAAAATAGGACG
TACCCATCTTCAAGATGCAGTACCTCTAACTCTTGGACAAGAAGTCTCTGCTTGGGCTGCTCAATTAGAGACTGCTTTAA
AACGCATTGAAATCAACATCGAGGAACTTTATCCACTTCCACTTGGAGGAACCGCTATTGGTACAGGGATTAATGCTCCT
AAAGATTTCGATAATTTAATCGCTCTTGAAATAGCCAAAAAAACAAATTTACCTTTTGAAACTGCAGCTAATAAATTTGC
CATCATGGCTAGTCATGATGGTCTTGTAAATATAATGTCTCAAATAAAATTACTAGCCGTCACTTTTCTCAAAATTGTTA
ATGATCTTCGACTTTTATCTTGTGGACCAAGAGCTGGATTATCAGAACTACAGCTTCCAGCCAATGAACCTGGCAGCTCA
ATAATGCCAGGAAAAATTAATCCTACTCAATGCGAAGCCATGGCAATGGTATGTACGCAAATAATTGGCATGGATACCTC
CGTATCGATAGCAGGAAGTGGAGGACATCTACAAATGAATGTCTATAAACCACTGATTGGCTACAACATTATAACAAGTA
TCAACCTTATTCAAAATGCCTGTAAGAGTTGCAGAGAGAATATGATTGAAAGTATTCAACCTAATCAAGCAAAAATCAAA
CAATTTCTAGACAATTCTTTGATGTTGGTAACCGCCTTATCGCCATCAATAGGATACGAAAAAGCAAGTAAAATTGCTCA
ACTAGCCCATGAAAAGAATCTAAGTCTAAGACAAGCTTCCAGTCAATTAAATTATCTTGATCAAGAAGAATTTGATAAAC
TCATGTGTCCAAAATCAATGATTGGAAGTGATTGA

Upstream 100 bases:

>100_bases
GTGAATACACTCTAAAAAGGTAAAAGAACTATATTTAATCAAAATCTATATTTATAATTTTCTATTCCTTAGAAACTTAA
AAATTCTCAACCCAATATCA

Downstream 100 bases:

>100_bases
AAAAAGTTTTTTCAATCTCCATTATGTCTTTCAGTCGCTGGATTAGTAAGTTCATGATTTTTTTCTTTTGCTTGATTAAT
ATCTTCAGCTTCACGAACTG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSNMKRLEKDSLGSIDVPKDALWGAQTQRSILNFAIGNEVIPLEIILAIAQIKASAAHVNNHLGLITTETAQFITEASLE
IIEGKHNDQFPVRVWQTGSGTQTNMNVNEVISNIASKRSNNALGSHNPIHPNDHVNCSQSTNDVFPAAIQIATIVTLKDT
LIPELTKLIDVFHQKSKEWKDIIKIGRTHLQDAVPLTLGQEVSAWAAQLETALKRIEINIEELYPLPLGGTAIGTGINAP
KDFDNLIALEIAKKTNLPFETAANKFAIMASHDGLVNIMSQIKLLAVTFLKIVNDLRLLSCGPRAGLSELQLPANEPGSS
IMPGKINPTQCEAMAMVCTQIIGMDTSVSIAGSGGHLQMNVYKPLIGYNIITSINLIQNACKSCRENMIESIQPNQAKIK
QFLDNSLMLVTALSPSIGYEKASKIAQLAHEKNLSLRQASSQLNYLDQEEFDKLMCPKSMIGSD

Sequences:

>Translated_464_residues
MSNMKRLEKDSLGSIDVPKDALWGAQTQRSILNFAIGNEVIPLEIILAIAQIKASAAHVNNHLGLITTETAQFITEASLE
IIEGKHNDQFPVRVWQTGSGTQTNMNVNEVISNIASKRSNNALGSHNPIHPNDHVNCSQSTNDVFPAAIQIATIVTLKDT
LIPELTKLIDVFHQKSKEWKDIIKIGRTHLQDAVPLTLGQEVSAWAAQLETALKRIEINIEELYPLPLGGTAIGTGINAP
KDFDNLIALEIAKKTNLPFETAANKFAIMASHDGLVNIMSQIKLLAVTFLKIVNDLRLLSCGPRAGLSELQLPANEPGSS
IMPGKINPTQCEAMAMVCTQIIGMDTSVSIAGSGGHLQMNVYKPLIGYNIITSINLIQNACKSCRENMIESIQPNQAKIK
QFLDNSLMLVTALSPSIGYEKASKIAQLAHEKNLSLRQASSQLNYLDQEEFDKLMCPKSMIGSD
>Mature_463_residues
SNMKRLEKDSLGSIDVPKDALWGAQTQRSILNFAIGNEVIPLEIILAIAQIKASAAHVNNHLGLITTETAQFITEASLEI
IEGKHNDQFPVRVWQTGSGTQTNMNVNEVISNIASKRSNNALGSHNPIHPNDHVNCSQSTNDVFPAAIQIATIVTLKDTL
IPELTKLIDVFHQKSKEWKDIIKIGRTHLQDAVPLTLGQEVSAWAAQLETALKRIEINIEELYPLPLGGTAIGTGINAPK
DFDNLIALEIAKKTNLPFETAANKFAIMASHDGLVNIMSQIKLLAVTFLKIVNDLRLLSCGPRAGLSELQLPANEPGSSI
MPGKINPTQCEAMAMVCTQIIGMDTSVSIAGSGGHLQMNVYKPLIGYNIITSINLIQNACKSCRENMIESIQPNQAKIKQ
FLDNSLMLVTALSPSIGYEKASKIAQLAHEKNLSLRQASSQLNYLDQEEFDKLMCPKSMIGSD

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=50.2164502164502, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI266458395, Length=93, Percent_Identity=37.6344086021505, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=48.590021691974, Blast_Score=470, Evalue=1e-133,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=39.4396551724138, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=49.0196078431373, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=48.9230769230769, Blast_Score=335, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=47.6293103448276, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=48.4782608695652, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=48.4782608695652, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=48.8069414316703, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=47.6190476190476, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=43.6285097192225, Blast_Score=409, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50572; Mature: 50441

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMKRLEKDSLGSIDVPKDALWGAQTQRSILNFAIGNEVIPLEIILAIAQIKASAAHVN
CCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
NHLGLITTETAQFITEASLEIIEGKHNDQFPVRVWQTGSGTQTNMNVNEVISNIASKRSN
CCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
NALGSHNPIHPNDHVNCSQSTNDVFPAAIQIATIVTLKDTLIPELTKLIDVFHQKSKEWK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DIIKIGRTHLQDAVPLTLGQEVSAWAAQLETALKRIEINIEELYPLPLGGTAIGTGINAP
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCC
KDFDNLIALEIAKKTNLPFETAANKFAIMASHDGLVNIMSQIKLLAVTFLKIVNDLRLLS
CCHHHHEEEEEHHHCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
CGPRAGLSELQLPANEPGSSIMPGKINPTQCEAMAMVCTQIIGMDTSVSIAGSGGHLQMN
CCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEE
VYKPLIGYNIITSINLIQNACKSCRENMIESIQPNQAKIKQFLDNSLMLVTALSPSIGYE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCHH
KASKIAQLAHEKNLSLRQASSQLNYLDQEEFDKLMCPKSMIGSD
HHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCC
>Mature Secondary Structure 
SNMKRLEKDSLGSIDVPKDALWGAQTQRSILNFAIGNEVIPLEIILAIAQIKASAAHVN
CCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
NHLGLITTETAQFITEASLEIIEGKHNDQFPVRVWQTGSGTQTNMNVNEVISNIASKRSN
CCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
NALGSHNPIHPNDHVNCSQSTNDVFPAAIQIATIVTLKDTLIPELTKLIDVFHQKSKEWK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DIIKIGRTHLQDAVPLTLGQEVSAWAAQLETALKRIEINIEELYPLPLGGTAIGTGINAP
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCC
KDFDNLIALEIAKKTNLPFETAANKFAIMASHDGLVNIMSQIKLLAVTFLKIVNDLRLLS
CCHHHHEEEEEHHHCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
CGPRAGLSELQLPANEPGSSIMPGKINPTQCEAMAMVCTQIIGMDTSVSIAGSGGHLQMN
CCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEE
VYKPLIGYNIITSINLIQNACKSCRENMIESIQPNQAKIKQFLDNSLMLVTALSPSIGYE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCHH
KASKIAQLAHEKNLSLRQASSQLNYLDQEEFDKLMCPKSMIGSD
HHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917486 [H]