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The map label for this gene is clpP [H]

Identifier: 124026440

GI number: 124026440

Start: 1420814

End: 1421416

Strand: Direct

Name: clpP [H]

Synonym: NATL1_17351

Alternate gene names: 124026440

Gene position: 1420814-1421416 (Clockwise)

Preceding gene: 124026439

Following gene: 124026441

Centisome position: 76.19

GC content: 41.29

Gene sequence:

>603_bases
ATGCCAATAGGTACTCCAAGCGTTCCATACCGTCTTCCAGGAAGTCAATTCGAAAGATGGGTTGATATTTACACAAGACT
AGGTGCGGAAAGAATTCTATTCCTTGGTCAAGAAGTAAACGACGGCATTGCAAATAGCCTCGTAGCACAAATGCTTTATC
TTGATTCTGAGGATAGTAGCAAGCCGATCTATTTGTATATCAATAGTCCTGGAGGGTCCGTAACCGCGGGTTTAGCTATC
TATGACACGATGAAATATGTAAAAAGCGACCTAGTAACTATTTGTGTTGGGTTGGCGGCCTCGATGGGTGCTTTTTTACT
CTCTGCAGGAACAAAAGGCAAAAGGCTTGCATTACCCCACAGCAGAATCATGATTCACCAGCCACTTGGCGGTACTGCGC
AAAGACAAGCAAGTGACATAGAGATTGAAGCACGTGAAATTCTTAGAATTAAAGAAATGCTCAATAAATCAATGGCAGAA
ATGACGGGACAAACATATGAAAAGATAGAAAAAGATACTGATCGTGATTACTTTTTGAGCGCGGAAGAAGCAAAAAATTA
CGGTCTAATCGACCGAGTAATTACACATCCAAGTGAAAGTTAA

Upstream 100 bases:

>100_bases
TAGAAAAGACTTGCCAGGCGAGAAAGTTTTGCCCACATAACCAAATTATTTTTACGAATTTTCAAGTCATTACCCTCAAC
TACTAAACATCAAATTAGCC

Downstream 100 bases:

>100_bases
GATGAAAAGTACTGCGTTCTAATTAATCAAATTGTCTTGATAGTCAAAAAAATATATCAATGAAAGTGGTTTCAATAGCA
CTCTATTTCGTAAGCTCAGC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MPIGTPSVPYRLPGSQFERWVDIYTRLGAERILFLGQEVNDGIANSLVAQMLYLDSEDSSKPIYLYINSPGGSVTAGLAI
YDTMKYVKSDLVTICVGLAASMGAFLLSAGTKGKRLALPHSRIMIHQPLGGTAQRQASDIEIEAREILRIKEMLNKSMAE
MTGQTYEKIEKDTDRDYFLSAEEAKNYGLIDRVITHPSES

Sequences:

>Translated_200_residues
MPIGTPSVPYRLPGSQFERWVDIYTRLGAERILFLGQEVNDGIANSLVAQMLYLDSEDSSKPIYLYINSPGGSVTAGLAI
YDTMKYVKSDLVTICVGLAASMGAFLLSAGTKGKRLALPHSRIMIHQPLGGTAQRQASDIEIEAREILRIKEMLNKSMAE
MTGQTYEKIEKDTDRDYFLSAEEAKNYGLIDRVITHPSES
>Mature_199_residues
PIGTPSVPYRLPGSQFERWVDIYTRLGAERILFLGQEVNDGIANSLVAQMLYLDSEDSSKPIYLYINSPGGSVTAGLAIY
DTMKYVKSDLVTICVGLAASMGAFLLSAGTKGKRLALPHSRIMIHQPLGGTAQRQASDIEIEAREILRIKEMLNKSMAEM
TGQTYEKIEKDTDRDYFLSAEEAKNYGLIDRVITHPSES

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=182, Percent_Identity=51.6483516483517, Blast_Score=195, Evalue=2e-50,
Organism=Escherichia coli, GI1786641, Length=182, Percent_Identity=62.0879120879121, Blast_Score=236, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17538017, Length=179, Percent_Identity=55.3072625698324, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129427, Length=183, Percent_Identity=54.0983606557377, Blast_Score=200, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22126; Mature: 21994

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIGTPSVPYRLPGSQFERWVDIYTRLGAERILFLGQEVNDGIANSLVAQMLYLDSEDSS
CCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCC
KPIYLYINSPGGSVTAGLAIYDTMKYVKSDLVTICVGLAASMGAFLLSAGTKGKRLALPH
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
SRIMIHQPLGGTAQRQASDIEIEAREILRIKEMLNKSMAEMTGQTYEKIEKDTDRDYFLS
CEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEE
AEEAKNYGLIDRVITHPSES
HHHHCCCCHHHHHHCCCCCC
>Mature Secondary Structure 
PIGTPSVPYRLPGSQFERWVDIYTRLGAERILFLGQEVNDGIANSLVAQMLYLDSEDSS
CCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCC
KPIYLYINSPGGSVTAGLAIYDTMKYVKSDLVTICVGLAASMGAFLLSAGTKGKRLALPH
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
SRIMIHQPLGGTAQRQASDIEIEAREILRIKEMLNKSMAEMTGQTYEKIEKDTDRDYFLS
CEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEE
AEEAKNYGLIDRVITHPSES
HHHHCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA