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The map label for this gene is ilvC

Identifier: 124026441

GI number: 124026441

Start: 1421546

End: 1422541

Strand: Direct

Name: ilvC

Synonym: NATL1_17361

Alternate gene names: 124026441

Gene position: 1421546-1422541 (Clockwise)

Preceding gene: 124026440

Following gene: 124026442

Centisome position: 76.23

GC content: 39.56

Gene sequence:

>996_bases
ATGGCAAAACTTTTTTACGATTCCGATGCAGACCTAGGTCTTCTTCAGGATAAAACCGTTGCAATTATTGGCTATGGATC
GCAAGGCCACGCGCATGCATTGAATTTAAAAGATAGTGGCATCAAAGTTGTTGTTGGGCTTTATGAAGGAAGTCGATCAG
CTAGCAAAGCAAAATCTGATGGATTGGAAGTTTTAAGCGTCGCGGAGGCTTCAGAAAGGGCAGATTGGATCATGATACTT
TTGCCTGATGAATTTCAAAAAGATGTTTACTCCAAAGAGATAGCACCTCATTTAAAAGCTGGAAAAATACTAAGTTTTGC
TCATGGTTTCAATATTCGCTTTGAATTAATAAAACCTCCTGAATTTGTCGATGTAGTAATGATTGCCCCAAAGGGACCAG
GTCACACTGTCAGATGGGAGTATCAAAATGGCCAAGGTGTTCCTGCTTTATTTGCAATTGAGCAAGATGCCTCAGGCAAT
GCAAGAGCACTTGCGATGGCATATGCAAAAGGTATTGGCGGAACACGCGCTGGGATTTTAGAAACCAATTTCAAAGAAGA
AACTGAAACTGATCTTTTTGGAGAACAAGCAGTTTTATGTGGAGGCCTTTCAGAGTTGGTCAAAGCTGGTTTTGAGACTC
TTGTTGAAGCTGGTTATCAACCTGAATTGGCCTACTTTGAATGCTTACACGAAGTCAAGCTAATAGTTGACCTCATGGTT
AAAGGAGGTCTAACTGCAATGAGGGATTCGATTTCAAATACAGCTGAGTATGGAGATTACGTAAGCGGTCCAAGATTAAT
AACCAAAGAGACAAAAGAAGAAATGAAAAATATTCTTGCCGATATTCAAGATGGTACTTTTGCTAAAAACTTTGTAAAAG
AATGCGATGCAGGCAAACCTGAAATGAAGAGAATTCGCCAAAAAGACTCAGAACTTCCAATAGAAAAAGTAGGAAAAACA
CTTCGCTCGATGTTTAGTTGGCTTAAATCAGACTAA

Upstream 100 bases:

>100_bases
AATTGTCTTGATAGTCAAAAAAATATATCAATGAAAGTGGTTTCAATAGCACTCTATTTCGTAAGCTCAGCCTTAATTCA
GTTCTGAAATACCCAATCAC

Downstream 100 bases:

>100_bases
ATATCATTCACTTAATCTTAGTTGCTGTTATTCTTGACCTTTTAATAGGTGATCCAAAAAGCTTGCCACACCCTGTCCAA
TTGATGGGTTTGGTTATTAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAKLFYDSDADLGLLQDKTVAIIGYGSQGHAHALNLKDSGIKVVVGLYEGSRSASKAKSDGLEVLSVAEASERADWIMIL
LPDEFQKDVYSKEIAPHLKAGKILSFAHGFNIRFELIKPPEFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGN
ARALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLTAMRDSISNTAEYGDYVSGPRLITKETKEEMKNILADIQDGTFAKNFVKECDAGKPEMKRIRQKDSELPIEKVGKT
LRSMFSWLKSD

Sequences:

>Translated_331_residues
MAKLFYDSDADLGLLQDKTVAIIGYGSQGHAHALNLKDSGIKVVVGLYEGSRSASKAKSDGLEVLSVAEASERADWIMIL
LPDEFQKDVYSKEIAPHLKAGKILSFAHGFNIRFELIKPPEFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGN
ARALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLTAMRDSISNTAEYGDYVSGPRLITKETKEEMKNILADIQDGTFAKNFVKECDAGKPEMKRIRQKDSELPIEKVGKT
LRSMFSWLKSD
>Mature_330_residues
AKLFYDSDADLGLLQDKTVAIIGYGSQGHAHALNLKDSGIKVVVGLYEGSRSASKAKSDGLEVLSVAEASERADWIMILL
PDEFQKDVYSKEIAPHLKAGKILSFAHGFNIRFELIKPPEFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGNA
RALAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMVK
GGLTAMRDSISNTAEYGDYVSGPRLITKETKEEMKNILADIQDGTFAKNFVKECDAGKPEMKRIRQKDSELPIEKVGKTL
RSMFSWLKSD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=36.8600682593857, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=32.4074074074074, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_PROM1 (A2C482)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015556.1
- ProteinModelPortal:   A2C482
- SMR:   A2C482
- STRING:   A2C482
- GeneID:   4779104
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_17361
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   PMAR167555:NATL1_17361-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36263; Mature: 36132

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLFYDSDADLGLLQDKTVAIIGYGSQGHAHALNLKDSGIKVVVGLYEGSRSASKAKSD
CCEEEECCCCCCEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHC
GLEVLSVAEASERADWIMILLPDEFQKDVYSKEIAPHLKAGKILSFAHGFNIRFELIKPP
CHHEEEHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCC
EFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGNARALAMAYAKGIGGTRAGIL
CEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLTAMRDSISNTAEYGDYVSGPRLITKETKEEMKNILADIQDGTFAKNFVKECDAGKP
HCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCH
EMKRIRQKDSELPIEKVGKTLRSMFSWLKSD
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKLFYDSDADLGLLQDKTVAIIGYGSQGHAHALNLKDSGIKVVVGLYEGSRSASKAKSD
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHC
GLEVLSVAEASERADWIMILLPDEFQKDVYSKEIAPHLKAGKILSFAHGFNIRFELIKPP
CHHEEEHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCC
EFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAIEQDASGNARALAMAYAKGIGGTRAGIL
CEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKAGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLTAMRDSISNTAEYGDYVSGPRLITKETKEEMKNILADIQDGTFAKNFVKECDAGKP
HCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCH
EMKRIRQKDSELPIEKVGKTLRSMFSWLKSD
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA