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The map label for this gene is phoR [H]

Identifier: 124025855

GI number: 124025855

Start: 1024379

End: 1025512

Strand: Direct

Name: phoR [H]

Synonym: NATL1_11481

Alternate gene names: 124025855

Gene position: 1024379-1025512 (Clockwise)

Preceding gene: 124025854

Following gene: 124025859

Centisome position: 54.93

GC content: 30.78

Gene sequence:

>1134_bases
ATGCTAAAAAAAATATTAAAAAAGCTACTCAAATTCATAAAAAAGATTCTCAGCATTAGAGGAGTTGGAACGACTATAAG
AAATGTTAGAAAGTGGCCTAAACGTCAACAATTTGTAGATGTCTCTCAAATCCTAAATTGGGTCGATAATATTAATCAGG
GTTGGATAATTATTACGTCTAAGAATAAAATCCTGTTTATCAATAAGCAAGCAAAGAAATTATTATCAATTAAAAAGGAT
TCAAAAATATTAGGGAAATCCCTCTTTAAACTTGAAATCCCAGATGAGATAAAGAGAGAAATTCAAAAGCTTAATAGGGC
AAAGACATTTAAAAGTATTCCTTATTTCTTTCATGAAAAAGAACTTGAAATTTCATTAATGCCTGGCTCAAAATCCACTA
CGCTAATACTTTTAACTAATAAGAGGTCTTTAGATTATCAACGTCAACTACAAGAGAGAATGTTAGGGGATGCCGCTCAT
GAATTAAAAACTCCATTAACTGCACTCATGTTGCTTGGAGATAGATTGGAGGATTTGGTCAAGAAAAAAGATAGACCATT
AATAAAGAGATTAAGAAAAGAAATTTTAAGACTAAAGTTGATGGTGAATGATTTACTGGAGTTGTCCAGATTGGTCAATT
CATCCTCAGTTCAGGATGAATTGACAAAAACAATTAATATGGAAGAAATTGTACTCAGTTCATGGAATACCCTTAAGCCG
CTGGCAGATAAGAAAAAATTAAATTTAGTTAATACATCGAAAACTAATTCTTTAATAGAGGGTAATTCTGAGAAATTATA
TAGGGTTGTTTTTAATTTGCTTGATAACGCAATTAGATATTCTCCTGATTCAGCTAACATCAATACTCAAATACATGAAG
ATGATAAACATCTAATTTTAAGTATCAAAGATGAAGGGCCAGGATTAAGTAAAGATGATCTGAAAAATATGTTTCAACGT
TTTTATAGAGGTGATCCATCTAGGTATAAAAATAAACGTATAGGTAGTGGTTTAGGTCTCTCAATAGCTCAACAAATAGT
TGTTAATCACAAAGGGGCTATTGAAGCTTCTAATGATACTAATGGTGGTACTTTGATGAAAATCAAATTACCTCTACAAA
AACAGATTGTTTAG

Upstream 100 bases:

>100_bases
TATTAGGTGGATTAGAGAAAAAATAGAGGATGATGCATCGGATCCAGACTATATAAGAACCGTTAGAGGTTTTGGCTACA
AATTTGGGTAAAGACGAATT

Downstream 100 bases:

>100_bases
TAAATATCTGGACAGTTTTTTCTTGCTATAAGTCGTTTCAAGTCTCGAACAGCATCACCAGTTAATAGATAACTACCATC
ATTTTCTTCATACCAATAGG

Product: two-component sensor histidine kinase, phosphate sensing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MLKKILKKLLKFIKKILSIRGVGTTIRNVRKWPKRQQFVDVSQILNWVDNINQGWIIITSKNKILFINKQAKKLLSIKKD
SKILGKSLFKLEIPDEIKREIQKLNRAKTFKSIPYFFHEKELEISLMPGSKSTTLILLTNKRSLDYQRQLQERMLGDAAH
ELKTPLTALMLLGDRLEDLVKKKDRPLIKRLRKEILRLKLMVNDLLELSRLVNSSSVQDELTKTINMEEIVLSSWNTLKP
LADKKKLNLVNTSKTNSLIEGNSEKLYRVVFNLLDNAIRYSPDSANINTQIHEDDKHLILSIKDEGPGLSKDDLKNMFQR
FYRGDPSRYKNKRIGSGLGLSIAQQIVVNHKGAIEASNDTNGGTLMKIKLPLQKQIV

Sequences:

>Translated_377_residues
MLKKILKKLLKFIKKILSIRGVGTTIRNVRKWPKRQQFVDVSQILNWVDNINQGWIIITSKNKILFINKQAKKLLSIKKD
SKILGKSLFKLEIPDEIKREIQKLNRAKTFKSIPYFFHEKELEISLMPGSKSTTLILLTNKRSLDYQRQLQERMLGDAAH
ELKTPLTALMLLGDRLEDLVKKKDRPLIKRLRKEILRLKLMVNDLLELSRLVNSSSVQDELTKTINMEEIVLSSWNTLKP
LADKKKLNLVNTSKTNSLIEGNSEKLYRVVFNLLDNAIRYSPDSANINTQIHEDDKHLILSIKDEGPGLSKDDLKNMFQR
FYRGDPSRYKNKRIGSGLGLSIAQQIVVNHKGAIEASNDTNGGTLMKIKLPLQKQIV
>Mature_377_residues
MLKKILKKLLKFIKKILSIRGVGTTIRNVRKWPKRQQFVDVSQILNWVDNINQGWIIITSKNKILFINKQAKKLLSIKKD
SKILGKSLFKLEIPDEIKREIQKLNRAKTFKSIPYFFHEKELEISLMPGSKSTTLILLTNKRSLDYQRQLQERMLGDAAH
ELKTPLTALMLLGDRLEDLVKKKDRPLIKRLRKEILRLKLMVNDLLELSRLVNSSSVQDELTKTINMEEIVLSSWNTLKP
LADKKKLNLVNTSKTNSLIEGNSEKLYRVVFNLLDNAIRYSPDSANINTQIHEDDKHLILSIKDEGPGLSKDDLKNMFQR
FYRGDPSRYKNKRIGSGLGLSIAQQIVVNHKGAIEASNDTNGGTLMKIKLPLQKQIV

Specific function: Member of the two-component regulatory system sphR/sphS. Sensory kinase. Is involved in inducible production of alkaline phosphatase in response to phosphate limitation as it is directly involved in the regulation of phoA transcription in response to phos

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=28.936170212766, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=31.5555555555556, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=29.7071129707113, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790551, Length=270, Percent_Identity=31.4814814814815, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=29.8701298701299, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=322, Percent_Identity=22.6708074534161, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789403, Length=222, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=27.8026905829596, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=310, Percent_Identity=23.5483870967742, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=27.9816513761468, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=24.0174672489083, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=25.4385964912281, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=23.963133640553, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=283, Percent_Identity=25.0883392226148, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=231, Percent_Identity=29.004329004329, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=217, Percent_Identity=26.2672811059908, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=24.5762711864407, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43385; Mature: 43385

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKILKKLLKFIKKILSIRGVGTTIRNVRKWPKRQQFVDVSQILNWVDNINQGWIIITS
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEC
KNKILFINKQAKKLLSIKKDSKILGKSLFKLEIPDEIKREIQKLNRAKTFKSIPYFFHEK
CCEEEEEEHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHCCHHEECC
ELEISLMPGSKSTTLILLTNKRSLDYQRQLQERMLGDAAHELKTPLTALMLLGDRLEDLV
CEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKKDRPLIKRLRKEILRLKLMVNDLLELSRLVNSSSVQDELTKTINMEEIVLSSWNTLKP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCC
LADKKKLNLVNTSKTNSLIEGNSEKLYRVVFNLLDNAIRYSPDSANINTQIHEDDKHLIL
CCCCHHCEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEE
SIKDEGPGLSKDDLKNMFQRFYRGDPSRYKNKRIGSGLGLSIAQQIVVNHKGAIEASNDT
EEECCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEECCCCC
NGGTLMKIKLPLQKQIV
CCCEEEEEECCHHHCCC
>Mature Secondary Structure
MLKKILKKLLKFIKKILSIRGVGTTIRNVRKWPKRQQFVDVSQILNWVDNINQGWIIITS
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEC
KNKILFINKQAKKLLSIKKDSKILGKSLFKLEIPDEIKREIQKLNRAKTFKSIPYFFHEK
CCEEEEEEHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHCCHHEECC
ELEISLMPGSKSTTLILLTNKRSLDYQRQLQERMLGDAAHELKTPLTALMLLGDRLEDLV
CEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKKDRPLIKRLRKEILRLKLMVNDLLELSRLVNSSSVQDELTKTINMEEIVLSSWNTLKP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCC
LADKKKLNLVNTSKTNSLIEGNSEKLYRVVFNLLDNAIRYSPDSANINTQIHEDDKHLIL
CCCCHHCEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEE
SIKDEGPGLSKDDLKNMFQRFYRGDPSRYKNKRIGSGLGLSIAQQIVVNHKGAIEASNDT
EEECCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEECCCCC
NGGTLMKIKLPLQKQIV
CCCEEEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497200 [H]