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The map label for this gene is psmB2

Identifier: 124028413

GI number: 124028413

Start: 1576524

End: 1577162

Strand: Direct

Name: psmB2

Synonym: Hbut_1567

Alternate gene names: 124028413

Gene position: 1576524-1577162 (Clockwise)

Preceding gene: 124028411

Following gene: 124028414

Centisome position: 94.56

GC content: 49.77

Gene sequence:

>639_bases
TTGCTACATCATCCCGGTACAGGCCAGCTGAGAGCACTGAAGGGCACAACAACTGTTGGCATAGTATTCCGCGACTTTGT
GGTACTCGCAGCAGACCGCAGGGCAACCGCAGGTTACTTCGTAGCACACAAGAGGACCAAGAAAATAATCAAGATAACAG
ACTACATGGCAATGACTACTGCTGGTCTCGTAGCAGATGCGCAAATGCTGGCTGAATGGCTGGCAAACCACACACACTAC
TATGAGATAGTCAACAAGAGGAGGATGAGCATCCACGCAGCCGCCCAGTACCTATCAATAATACTACATTCTGCAAAGTT
CTACCCATACATAGTACAGCTACTCCTTGGAGGCTACGATACACAGCCAAGACTATACAACATAGACTGGTTCGGCAGTG
TAACAGAGGAAAAGTACGTCGCTACGGGCTCCGGCTCGCCAACAGCTATAGGCGTCATAGAAGATCAGTACAGCCCTAAC
CTGAGTATGGAGGAGGCTGTAGAACTCGCAAAAAGAGCCGTAGCATCCTCCATAAGGCGCGACACCTTCACCGGCAACGG
TGTGGACGTCGTAGTCATAGGCAAGGACTTCTACCGCGAATACTCCTTCGAGCTAAAAGACATACTGAAAACCAAGTAG

Upstream 100 bases:

>100_bases
CTTACACAGCACCTAGCTCTGAAACGCTCTGTAGAAGCCAGGAAAATAAACTCTATTTAGGCTTCCCGCATTGTAAGCCC
CGCATACCGGGTAGCAAGAC

Downstream 100 bases:

>100_bases
GACTAAACCTAGGTAGTATGGATATGGCATAAGTTTCTAGGATAAAGCCATAGCCATATTTCTGGCCACATTTGCCGAAA
ACCTAATAACACCCCAAATG

Product: proteasome beta precursor

Products: NA

Alternate protein names: 20S proteasome beta subunit 2; Proteasome core protein PsmB 2

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MLHHPGTGQLRALKGTTTVGIVFRDFVVLAADRRATAGYFVAHKRTKKIIKITDYMAMTTAGLVADAQMLAEWLANHTHY
YEIVNKRRMSIHAAAQYLSIILHSAKFYPYIVQLLLGGYDTQPRLYNIDWFGSVTEEKYVATGSGSPTAIGVIEDQYSPN
LSMEEAVELAKRAVASSIRRDTFTGNGVDVVVIGKDFYREYSFELKDILKTK

Sequences:

>Translated_212_residues
MLHHPGTGQLRALKGTTTVGIVFRDFVVLAADRRATAGYFVAHKRTKKIIKITDYMAMTTAGLVADAQMLAEWLANHTHY
YEIVNKRRMSIHAAAQYLSIILHSAKFYPYIVQLLLGGYDTQPRLYNIDWFGSVTEEKYVATGSGSPTAIGVIEDQYSPN
LSMEEAVELAKRAVASSIRRDTFTGNGVDVVVIGKDFYREYSFELKDILKTK
>Mature_212_residues
MLHHPGTGQLRALKGTTTVGIVFRDFVVLAADRRATAGYFVAHKRTKKIIKITDYMAMTTAGLVADAQMLAEWLANHTHY
YEIVNKRRMSIHAAAQYLSIILHSAKFYPYIVQLLLGGYDTQPRLYNIDWFGSVTEEKYVATGSGSPTAIGVIEDQYSPN
LSMEEAVELAKRAVASSIRRDTFTGNGVDVVVIGKDFYREYSFELKDILKTK

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506201, Length=203, Percent_Identity=34.9753694581281, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI73747875, Length=203, Percent_Identity=33.0049261083744, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4758970, Length=203, Percent_Identity=33.0049261083744, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4506203, Length=197, Percent_Identity=36.5482233502538, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4506191, Length=183, Percent_Identity=34.4262295081967, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI4506193, Length=217, Percent_Identity=28.110599078341, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI153791216, Length=195, Percent_Identity=31.2820512820513, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI222144262, Length=126, Percent_Identity=35.7142857142857, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI22538465, Length=193, Percent_Identity=25.9067357512953, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI195539356, Length=137, Percent_Identity=32.1167883211679, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4506195, Length=184, Percent_Identity=27.7173913043478, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI23110925, Length=183, Percent_Identity=24.5901639344262, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI23110942, Length=214, Percent_Identity=22.8971962616822, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17508499, Length=188, Percent_Identity=29.7872340425532, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17541700, Length=187, Percent_Identity=32.0855614973262, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17508495, Length=181, Percent_Identity=31.4917127071823, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17535357, Length=185, Percent_Identity=26.4864864864865, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554384, Length=194, Percent_Identity=24.7422680412371, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508493, Length=188, Percent_Identity=25, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6325360, Length=192, Percent_Identity=31.25, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319430, Length=213, Percent_Identity=27.2300469483568, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324731, Length=193, Percent_Identity=34.1968911917098, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320849, Length=189, Percent_Identity=29.1005291005291, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322459, Length=181, Percent_Identity=28.1767955801105, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320941, Length=189, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323974, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321574, Length=206, Percent_Identity=25.7281553398058, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355573, Length=185, Percent_Identity=36.2162162162162, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24652553, Length=185, Percent_Identity=36.2162162162162, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20130281, Length=187, Percent_Identity=32.620320855615, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24639979, Length=186, Percent_Identity=32.7956989247312, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664391, Length=193, Percent_Identity=33.160621761658, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24584895, Length=172, Percent_Identity=32.5581395348837, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653999, Length=189, Percent_Identity=32.8042328042328, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17737605, Length=196, Percent_Identity=31.1224489795918, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573221, Length=194, Percent_Identity=29.8969072164948, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24654391, Length=205, Percent_Identity=27.8048780487805, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24654389, Length=205, Percent_Identity=27.8048780487805, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24581176, Length=186, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI20129563, Length=190, Percent_Identity=27.8947368421053, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355629, Length=189, Percent_Identity=24.3386243386243, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921232, Length=190, Percent_Identity=27.8947368421053, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550918, Length=181, Percent_Identity=27.0718232044199, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB2_HYPBU (A2BN27)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013733.1
- ProteinModelPortal:   A2BN27
- SMR:   A2BN27
- MEROPS:   T01.002
- GeneID:   4782914
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_1567
- eggNOG:   arNOG10234
- HOGENOM:   HBG499923
- OMA:   MAYGVLE
- PhylomeDB:   A2BN27
- ProtClustDB:   CLSK964569
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 23762; Mature: 23762

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 16-16

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHHPGTGQLRALKGTTTVGIVFRDFVVLAADRRATAGYFVAHKRTKKIIKITDYMAMTT
CCCCCCCCCEEEECCCCEEHHHHHHHHHEECCCCCCCCEEEEHHHHHHHEEHHHHHHHHH
AGLVADAQMLAEWLANHTHYYEIVNKRRMSIHAAAQYLSIILHSAKFYPYIVQLLLGGYD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TQPRLYNIDWFGSVTEEKYVATGSGSPTAIGVIEDQYSPNLSMEEAVELAKRAVASSIRR
CCCEEEEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
DTFTGNGVDVVVIGKDFYREYSFELKDILKTK
CCCCCCCEEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLHHPGTGQLRALKGTTTVGIVFRDFVVLAADRRATAGYFVAHKRTKKIIKITDYMAMTT
CCCCCCCCCEEEECCCCEEHHHHHHHHHEECCCCCCCCEEEEHHHHHHHEEHHHHHHHHH
AGLVADAQMLAEWLANHTHYYEIVNKRRMSIHAAAQYLSIILHSAKFYPYIVQLLLGGYD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TQPRLYNIDWFGSVTEEKYVATGSGSPTAIGVIEDQYSPNLSMEEAVELAKRAVASSIRR
CCCEEEEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
DTFTGNGVDVVVIGKDFYREYSFELKDILKTK
CCCCCCCEEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA